UK-414,495

UK-414,495
(IUPAC) ime
	(R)-2-({1-[(5-etil-1,3,4-tiadiazol-2-il)karbamoil]ciklopentil}metil)valerinska kiselina
Klinički podaci
Identifikatori
CAS broj	337962-93-3
ATC kod	nije dodeljen
PubChem	9949799
Hemijski podaci
Formula	C16H25N3O3S
Mol. masa	339,452 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22) ; Key: FWXXCSISWQQOGS-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

UK-414,495 je lek koji je razvila kompanija Pfizer za tretman poremećaja ženskog seksualnog nadražaja.^[3] UK-414,495 deluje kao potentan i selektivan inhibitor enzima neutralna endopeptidaza, čija normalna funkcija je razlaganje neuropeptida VIP. Konsekventno povećanje VIP aktivnosti menja protok krvi u genitalnom regionu, što dovodi do povećanja lubrikacije i mišične relaksacije.^[4]^[5]^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ 'Female Viagra' will help women increase their sexual arousal. Daily Mail Online 14th April 2010
↑ Armer R, Warne P, Witherington J (2006). „Recent disclosures of clinical drug candidates”. Drug News & Perspectives 19 (1): 65–72. PMID 16550257. ISSN 0214-0934
↑ Angulo J. (2010). „Neutral endopeptidase inhibition: could it have a role in the treatment of female sexual arousal disorder?”. British Journal of Pharmacology 160: 48. DOI:10.1111/j.1476-5381.2010.00693.x.
↑ Wayman C., Baxter D., Turner L., Van Der Graaf P., Naylor A. (2010). „UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit”. British Journal of Pharmacology 160 (1): 51–59. DOI:10.1111/j.1476-5381.2010.00691.x. PMC 2860206. PMID 20412068.

Povezano

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] 'Female Viagra' will help women increase their sexual arousal. Daily Mail Online 14th April 2010

[pmid16550257-4] Armer R, Warne P, Witherington J (2006). „Recent disclosures of clinical drug candidates”. Drug News & Perspectives 19 (1): 65–72. PMID 16550257. ISSN 0214-0934

[5] Angulo J. (2010). „Neutral endopeptidase inhibition: could it have a role in the treatment of female sexual arousal disorder?”. British Journal of Pharmacology 160: 48. DOI:10.1111/j.1476-5381.2010.00693.x.

[6] Wayman C., Baxter D., Turner L., Van Der Graaf P., Naylor A. (2010). „UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit”. British Journal of Pharmacology 160 (1): 51–59. DOI:10.1111/j.1476-5381.2010.00691.x. PMC 2860206. PMID 20412068.

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