CCL26

Hemokin (C-C motiv) ligand 26
Hemokin (C-C motiv) ligand 26
Identifikatori
Simbol	CCL26
Alt. simboli	SCYA26, MIP-4alpha, eotaxin-3, IMAC, MIP-4a, TSC-1
Entrez	10344
HUGO	10625
OMIM	604697
PDB	1G2T
RefSeq	NM_006072
UniProt	Q9Y258
Ostali podaci
Lokus	Hromozom 7 q11.2

CCL26, hemokin (C-C motiv) ligand 26, je mali citokin iz CC hemokin familije koji je takođe poznat kao eotaksin-3, makrofagni inflamatorni protein 4-alfa (MIP-4-alfa), timusni stromalni hemokin-1 (TSC-1), i IMAC. On je izražen u više tkiva u srcu, plućima i jajnicima, i u endotelnim ćelijama nakon stimulacije sa citokinom IL-4.^[1]^[2] CCL26 je hemotaksan za eozinofile i bazofile. On dejstvuje vezivanjem za hemokinski receptor CCR3 na ćelijskoj površini.^[3] Gen ovog hemokina je lociran na ljudskom hromozomu 7.^[4]^[5]

Reference

^ Shinkai; et al. (1999). „A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils”. J. Immunol. 163: 1602—1610.
^ Guo; et al. (1999). „Molecular cloning and characterization of a novel human CC chemokine, SCYA26”. Genomics. 58: 313—317.
^ Kitaura; et al. (1999). „Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3”. J. Biol. Chem. 274: 27975—27980.
^ Hillier; et al. (2003). „The DNA sequence of human chromosome 7”. Nature. 424: 157—164.
^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.