Limfotoksin beta receptor

Limfotoksin beta receptor (TNFR superfamilija, član 3)
Kristalografska struktura peptida sa 24 ostatka iz limfotoksin-B receptora vezanog za TRAF3.[1]
Dostupne strukture
1RF3​
Identifikatori
Simboli	LTBR; CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR; TNFR-RP; TNFR2-RP; TNFRSF3
Vanjski ID	OMIM: 600979 MGI: 104875 HomoloGene: 1753 GeneCards: LTBR Gene
Ontologija gena Molekularna funkcija • aktivnost transmembranskog receptora • proteinsko vezivanje Celularna komponenta • membrana • integralno sa membranom Biološki proces • apoptoza • imunski respons • prenos signala • positivna regulacija I-kapaB kinaza/NF-kapaB kaskade
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	4055	17000
Ensembl	ENSG00000111321	n/a
UniProt	P36941	n/a
RefSeq (mRNA)	NM_002342	XM_982227
RefSeq (protein)	NP_002333	XP_987321
Lokacija (UCSC)	Chr 12: 6.36 - 6.37 Mb	n/a
PubMed pretraga	[1]	[2]

Референце

1. ’PDB: 1RF3​; Li C, Norris PS, Ni CZ, Havert ML, Chiong EM, Tran BR, Cabezas E, Reed JC, Satterthwait AC, Ware CF, Ely KR (2003). „Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling”. J. Biol. Chem. 278 (50): 50523—9. PMID 14517219. doi:10.1074/jbc.M309381200. 

Limfotoksin beta receptor je receptor za limfotoksin koji je kod ljudi kodiran LTBR genom.^[1][2][3]

Funkcija

Protein kodiran ovim genom je član TNF familije receptora. On je izražen na površini većine ćelijskih tipova, uključujući ćelije epitelnog i mijeloidnog porekla, ali ne na T i B limfocitima. Ovaj protein specifično vezuje limfotoksin membransku formu (kompleks limfotoksina-alfa i limftoksina-beta se formira). Limftoksin-beta i njegov ligand učestvuju u razvoju i organizaciji limfoidnog tkiva. Aktivacija ovog proteina može da podstakne apoptozu.^[1]

Ne samp da LTBR pomaže u podsticanju apoptoze, on može da dovede do oslobađanja citokina interleukin 8. Prekomerno LTBR izražavanje u HEK293 ćelima povećava IL-8 promotorsku aktivnost, i dovodi do IL-8 oslobađanja. LTBR je takođe esencijalan za razvoj i organizaciju sekundarnih limfoidnih organa i oslobađanje drugih hemokina.^[4]

Struktura

Ramačandranov dijagram pokazuje da je 64.6% ostataka u poželjnom regionu.^[5] Ova structura je ustanovljena putem difrakcije X-zraka. Njena rezolucija je 3.50 Å. Alfa i beta uglovi su 90 stepeni, dok je gama ugao 120 stepeni.

Interakcije

Za limfotoksin beta receptor je bilo pokazano da interaguje sa Dijablo homologom^[6] i TRAF3.^[7][8][9]

Reference

1. „Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)”. 
2. Baens M, Chaffanet M, Cassiman JJ, van den Berghe H, Marynen P (1993). „Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid”. Genomics. 16 (1): 214—8. PMID 8486360. doi:10.1006/geno.1993.1161. 
3. Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA (1994). „A lymphotoxin-beta-specific receptor”. Science (journal). 264 (5159): 707—10. PMID 8171323. doi:10.1126/science.8171323. 
4. Chang YH, Hsieh SL, Chen MC, Lin WW (2002). „Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation”. Exp. Cell Res. 278 (2): 166—74. PMID 12169272. doi:10.1006/excr.2002.5573. 
5. „MolProbity Ramachandran analysis” (PDF). Архивирано из оригинала (PDF) 12. 10. 2012. г. 
6. Kuai, Jun; Nickbarg Elliott; et al. (2003). „Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis”. J. Biol. Chem. United States. 278 (16): 14363—9. ISSN 0021-9258. PMID 12571250. doi:10.1074/jbc.M208672200. 
7. VanArsdale, T L; VanArsdale S L; et al. (1997). „Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 94 (6): 2460—5. ISSN 0027-8424. PMC 20110 . PMID 9122217. doi:10.1073/pnas.94.6.2460. 
8. Wu, M Y; Wang P Y; et al. (1999). „The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells”. J. Biol. Chem. UNITED STATES. 274 (17): 11868—73. ISSN 0021-9258. PMID 10207006. doi:10.1074/jbc.274.17.11868. 
9. Marsters, S A; Ayres T M; et al. (1997). „Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1”. J. Biol. Chem. UNITED STATES. 272 (22): 14029—32. ISSN 0021-9258. PMID 9162022. doi:10.1074/jbc.272.22.14029. 

Literatura

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• Browning JL; Ngam-ek A; Lawton P; et al. (1993). „Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface.”. Cell. 72 (6): 847—56. PMID 7916655. doi:10.1016/0092-8674(93)90574-A. 
• Crowe PD; VanArsdale TL; Walter BN; et al. (1994). „A lymphotoxin-beta-specific receptor.”. Science. 264 (5159): 707—10. PMID 8171323. doi:10.1126/science.8171323. 
• Baens M; Chaffanet M; Cassiman JJ; et al. (1993). „Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid.”. Genomics. 16 (1): 214—8. PMID 8486360. doi:10.1006/geno.1993.1161. 
• Baens M; Aerssens J; van Zand K; et al. (1996). „Isolation and regional assignment of human chromosome 12p cDNAs.”. Genomics. 29 (1): 44—52. PMID 8530100. doi:10.1006/geno.1995.1213. 
• Wang X; Bornslaeger EA; Haub O; et al. (1996). „A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein.”. Dev. Biol. 177 (1): 274—90. PMID 8660894. doi:10.1006/dbio.1996.0162. 
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• VanArsdale TL; VanArsdale SL; Force WR; et al. (1997). „Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB.”. Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2460—5. PMC 20110 . PMID 9122217. doi:10.1073/pnas.94.6.2460. 
• Wu MY; Hsu TL; Lin WW; et al. (1997). „Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells.”. J. Biol. Chem. 272 (27): 17154—9. PMID 9202035. doi:10.1074/jbc.272.27.17154. 
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• Wu MY, Wang PY, Han SH, Hsieh SL (1999). „The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells.”. J. Biol. Chem. 274 (17): 11868—73. PMID 10207006. doi:10.1074/jbc.274.17.11868. 
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• Chang YH, Hsieh SL, Chen MC, Lin WW (2002). „Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation.”. Exp. Cell Res. 278 (2): 166—74. PMID 12169272. doi:10.1006/excr.2002.5573. 

Spoljašnje veze

• Lymphotoxin+beta+Receptor на US National Library of Medicine Medical Subject Headings (MeSH)