KRT85

KRT85
Identifiers
Aliases	KRT85, ECTD4, HB5, Hb-5, K85, KRTHB5, hHb5, keratin 85
External IDs	OMIM: 602767; MGI: 1859268; HomoloGene: 37603; GeneCards: KRT85; OMA:KRT85 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 52,360,006 bp[1] End 52,367,481 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F2|15 Start 101,413,801 bp[2] End 101,422,054 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm sperm testicle skin of hip hair follicle skin of thigh nipple gonad right lung skin of abdomen Top expressed in lip zone of skin testicle spermatid limb islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity Cellular component intermediate filament keratin filament extracellular space cytosol Biological process epidermis development keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3891 53622 Ensembl ENSG00000135443 ENSMUSG00000116336 UniProt P78386 Q9Z2T6 RefSeq (mRNA) NM_002283 NM_001300810 NM_016879 RefSeq (protein) NP_001287739 NP_002274 NP_058575 Location (UCSC) Chr 12: 52.36 – 52.37 Mb Chr 15: 101.41 – 101.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.^[5][6][7]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000135443 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000116336 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rogers MA, Langbein L, Praetzel S, Moll I, Krieg T, Winter H, et al. (April 1997). "Sequences and differential expression of three novel human type-II hair keratins". Differentiation; Research in Biological Diversity. 61 (3): 187–194. doi:10.1046/j.1432-0436.1997.6130187.x. PMID 9084137.
6. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, et al. (July 2006). "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology. 174 (2): 169–174. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
7. "Entrez Gene: KRT85 keratin 85".

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Naeem M, Wajid M, Lee K, Leal SM, Ahmad W (March 2006). "A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type". Journal of Medical Genetics. 43 (3): 274–279. doi:10.1136/jmg.2005.033381. PMC 2563238. PMID 16525032.
• Tang K, Finley RL, Nie D, Honn KV (March 2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening". Biochemistry. 39 (12): 3185–3191. doi:10.1021/bi992664v. PMID 10727209.
• Rogers MA, Winter H, Langbein L, Wolf C, Schweizer J (March 2000). "Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain". The Journal of Investigative Dermatology. 114 (3): 464–472. doi:10.1046/j.1523-1747.2000.00910.x. PMID 10692104.
• Langbein L, Rogers MA, Winter H, Praetzel S, Beckhaus U, Rackwitz HR, et al. (July 1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". The Journal of Biological Chemistry. 274 (28): 19874–19884. doi:10.1074/jbc.274.28.19874. PMID 10391933.
• Rogers MA, Winter H, Langbein L, Krieg T, Schweizer J (October 1996). "Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5". The Journal of Investigative Dermatology. 107 (4): 633–638. doi:10.1111/1523-1747.ep12584243. PMID 8823373.