KIF19

KIF19
Identifiers
Aliases	KIF19, KIF19A, kinesin family member 19
External IDs	MGI: 2447024; HomoloGene: 17709; GeneCards: KIF19; OMA:KIF19 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 74,326,210 bp[1] End 74,355,820 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 114,656,214 bp[2] End 114,681,565 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube sural nerve olfactory zone of nasal mucosa spleen granulocyte C1 segment hypothalamus amygdala caudate nucleus putamen Top expressed in islet of Langerhans spermatocyte hypothalamus testicle lens ovary spermatid embryo morula striatum of neuraxis More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding microtubule motor activity nucleotide binding ATPase activity plus-end-directed microtubule motor activity ATP binding Cellular component cytoplasm axoneme cell projection cilium microtubule cytoskeleton kinesin complex Biological process microtubule-based movement axonemal microtubule depolymerization plus-end specific microtubule depolymerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 124602 286942 Ensembl ENSG00000196169 ENSMUSG00000010021 UniProt Q2TAC6 Q99PT9 RefSeq (mRNA) NM_153209 NM_001102615 RefSeq (protein) NP_694941 NP_001096085 Location (UCSC) Chr 17: 74.33 – 74.36 Mb Chr 11: 114.66 – 114.68 Mb PubMed search [3] [4]
Wikidata
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Kinesin family member 19 (KIF19) is a protein in humans encoded by the KIF19 gene. It is part of the kinesin family of motor proteins.

Function

KIF19 is involved in cancer metastasis, as well as cell-cell and cell-matrix interactions.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000196169 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000010021 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Eisenberg, Samuel C.; Dey, Abhinav; Birnbaum, Rayna; Sharp, David J. (2020-09-04). "The kinesin-8 member Kif19 alters microtubule dynamics, suppresses cell adhesion, and promotes cancer cell invasion". bioRxiv 10.1101/2020.09.04.282657.