ADGRL2
Latrofilin 2 jest protein koji je kod ljudi kodiran genom ADGRL2 sa hromosoma 1.[5][6]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 1.459 aminokiselina, a molekulska težina 163.349 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MVSSGCRMRS | LWFIIVISFL | PNTEGFSRAA | LPFGLVRREL | SCEGYSIDLR | ||||
| CPGSDVIMIE | SANYGRTDDK | ICDADPFQME | NTDCYLPDAF | KIMTQRCNNR | ||||
| TQCIVVTGSD | VFPDPCPGTY | KYLEVQYECV | PYIFVCPGTL | KAIVDSPCIY | ||||
| EAEQKAGAWC | KDPLQAADKI | YFMPWTPYRT | DTLIEYASLE | DFQNSRQTTT | ||||
| YKLPNRVDGT | GFVVYDGAVF | FNKERTRNIV | KFDLRTRIKS | GEAIINYANY | ||||
| HDTSPYRWGG | KTDIDLAVDE | NGLWVIYATE | QNNGMIVISQ | LNPYTLRFEA | ||||
| TWETVYDKRA | ASNAFMICGV | LYVVRSVYQD | NESETGKNSI | DYIYNTRLNR | ||||
| GEYVDVPFPN | QYQYIAAVDY | NPRDNQLYVW | NNNFILRYSL | EFGPPDPAQV | ||||
| PTTAVTITSS | AELFKTIIST | TSTTSQKGPM | STTVAGSQEG | SKGTKPPPAV | ||||
| STTKIPPITN | IFPLPERFCE | ALDSKGIKWP | QTQRGMMVER | PCPKGTRGTA | ||||
| SYLCMISTGT | WNPKGPDLSN | CTSHWVNQLA | QKIRSGENAA | SLANELAKHT | ||||
| KGPVFAGDVS | SSVRLMEQLV | DILDAQLQEL | KPSEKDSAGR | SYNKLQKREK | ||||
| TCRAYLKAIV | DTVDNLLRPE | ALESWKHMNS | SEQAHTATML | LDTLEEGAFV | ||||
| LADNLLEPTR | VSMPTENIVL | EVAVLSTEGQ | IQDFKFPLGI | KGAGSSIQLS | ||||
| ANTVKQNSRN | GLAKLVFIIY | RSLGQFLSTE | NATIKLGADF | IGRNSTIAVN | ||||
| SHVISVSINK | ESSRVYLTDP | VLFTLPHIDP | DNYFNANCSF | WNYSERTMMG | ||||
| YWSTQGCKLV | DTNKTRTTCA | CSHLTNFAIL | MAHREIAYKD | GVHELLLTVI | ||||
| TWVGIVISLV | CLAICIFTFC | FFRGLQSDRN | TIHKNLCINL | FIAEFIFLIG | ||||
| IDKTKYAIAC | PIFAGLLHFF | FLAAFAWMCL | EGVQLYLMLV | EVFESEYSRK | ||||
| KYYYVAGYLF | PATVVGVSAA | IDYKSYGTEK | ACWLHVDNYF | IWSFIGPVTF | ||||
| IILLNIIFLV | ITLCKMVKHS | NTLKPDSSRL | ENIKSWVLGA | FALLCLLGLT | ||||
| WSFGLLFINE | ETIVMAYLFT | IFNAFQGVFI | FIFHCALQKK | VRKEYGKCFR | ||||
| HSYCCGGLPT | ESPHSSVKAS | TTRTSARYSS | GTQSRIRRMW | NDTVRKQSES | ||||
| SFISGDINST | STLNQGMTGN | YLLTNPLLRP | HGTNNPYNTL | LAETVVCNAP | ||||
| SAPVFNSPGH | SLNNARDTSA | MDTLPLNGNF | NNSYSLHKGD | YNDSVQVVDC | ||||
| GLSLNDTAFE | KMIISELVHN | NLRGSSKTHN | LELTLPVKPV | IGGSSSEDDA | ||||
| IVADASSLMH | SDNPGLELHH | KELEAPLIPQ | RTHSLLYQPQ | KKVKSEGTDS | ||||
| YVSQLTAEAE | DHLQSPNRDS | LYTSMPNLRD | SPYPESSPDM | EEDLSPSRRS | ||||
| ENEDIYYKSM | PNLGAGHQLQ | MCYQISRGNS | DGYIIPINKE | GCIPEGDVRE | ||||
| GQMQLVTSL |
Funkcija
[uredi | uredi izvor]Ovaj gen kodira člana potporodice latrofilinskih receptora vezanih za G-protein (GPCR). Latrofilini mogu funkcionirati i u ćelijskoj adheziji i u prijenosu signala. U eksperimentima s neljudskim vrstama, endogeno proteolitsko cijepanje unutar cisteinom bogatog GPS domena (mjesto proteolize G-protein spregnutog receptora) rezultiralo je u dvije podjedinice (velika vanćelijska N-terminal podjedinica ćelijske adhezije i podjedinica sa značajnom sličnošću sa porodica sekretin/kalcitonin GPCR-a) koji su nekovalentno vezani na ćelijskoj membrani. Iako je opisano nekoliko varijanti transkripta, utvrđena je biološka valjanost samo jedne.[6]
Također pogledajte
[uredi | uredi izvor]Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000117114 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028184 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ White GR, Varley JM, Heighway J (Apr 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1491 (1–3): 75–92. doi:10.1016/s0167-4781(00)00020-8. PMID 10760572.
- ^ a b c "Entrez Gene: LPHN2 latrophilin 2".
Dopunska literatura
[uredi | uredi izvor]- Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins". Annual Review of Neuroscience. 24 (1): 933–62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923.
- Ushkaryov YA, Volynski KE, Ashton AC (Apr 2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies". Toxicon. 43 (5): 527–42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411.
- Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
- White GR, Varley JM, Heighway J (Dec 1998). "Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer". Oncogene. 17 (26): 3513–9. doi:10.1038/sj.onc.1202487. PMID 10030676.
- Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (Oct 2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". The Journal of Biological Chemistry. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.
- Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
- Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE (2007). "Discovery of tissue-specific exons using comprehensive human exon microarrays". Genome Biology. 8 (4): R64. doi:10.1186/gb-2007-8-4-r64. PMC 1896007. PMID 17456239.
Vanjski linkovi
[uredi | uredi izvor]Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.