ARID4B

ARID4B
Identifikatori
Aliasi	ARID4B
Vanjski ID-jevi	OMIM: 609696 MGI: 2137512 HomoloGene: 12847 GeneCards: ARID4B
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1q42.3 Početak 235,131,634 bp[1] Kraj 235,328,219 bp[1]
Lokacija gena (miš) Hrom. Hromosom 13 (miš)[2] Bend 13 A1|13 5.29 cM Početak 14,237,817 bp[2] Kraj 14,374,188 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • histone deacetylase activity • molekularna funkcija • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • citoplazma • nukleoplazma • jedro • ćelijska komponenta Biološki proces • regulation of gene expression by genetic imprinting • GO:0009373 regulation of transcription, DNA-templated • establishment of Sertoli cell barrier • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • histone H4-K20 trimethylation • transcription, DNA-templated • histone H3-K9 trimethylation • Spermatogeneza • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • histone deacetylation • GO:0022610 biološki proces • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	51742	94246
Ensembl	ENSG00000054267	ENSMUSG00000039219
UniProt	Q4LE39	A2CG63
RefSeq (mRNK)	NM_001206794 NM_016374 NM_031371	NM_194262 NM_198122
RefSeq (bjelančevina)	NP_001193723 NP_057458 NP_112739	NP_919238 NP_937755
Lokacija (UCSC)	Chr 1: 235.13 – 235.33 Mb	Chr 13: 14.24 – 14.37 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

AT-bogati protein 4B sa interaktivnim domenom jest protein koji je kod ljudi kodiran genom ARID4B sa hromosoma 1.^[5][6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.312 aminokiselina, a molekulska 147.809 težina Da.^[7]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MKALDEPPYL		TVGTDVSAKY		RGAFCEAKIK		TAKRLVKVKV		TFRHDSSTVE
VQDDHIKGPL		KVGAIVEVKN		LDGAYQEAVI		NKLTDASWYT		VVFDDGDEKT
LRRSSLCLKG		ERHFAESETL		DQLPLTNPEH		FGTPVIGKKT		NRGRRSNHIP
EEESSSSSSD		EDEDDRKQID		ELLGKVVCVD		YISLDKKKAL		WFPALVVCPD
CSDEIAVKKD		NILVRSFKDG		KFTSVPRKDV		HEITSDTAPK		PDAVLKQAFE
QALEFHKSRT		IPANWKTELK		EDSSSSEAEE		EEEEEDDEKE		KEDNSSEEEE
EIEPFPEERE		NFLQQLYKFM		EDRGTPINKR		PVLGYRNLNL		FKLFRLVHKL
GGFDNIESGA		VWKQVYQDLG		IPVLNSAAGY		NVKCAYKKYL		YGFEEYCRSA
NIEFQMALPE		KVVNKQCKEC		ENVKEIKVKE		ENETEIKEIK		MEEERNIIPR
EEKPIEDEIE		RKENIKPSLG		SKKNLLESIP		THSDQEKEVN		IKKPEDNENL
DDKDDDTTRV		DESLNIKVEA		EEEKAKSGDE		TNKEEDEDDE		EAEEEEEEEE
EEEDEDDDDN		NEEEEFECYP		PGMKVQVRYG		RGKNQKMYEA		SIKDSDVEGG
EVLYLVHYCG		WNVRYDEWIK		ADKIVRPADK		NVPKIKHRKK		IKNKLDKEKD
KDEKYSPKNC		KLRRLSKPPF		QTNPSPEMVS		KLDLTDAKNS		DTAHIKSIEI
TSILNGLQAS		ESSAEDSEQE		DERGAQDMDN		NGKEESKIDH		LTNNRNDLIS
KEEQNSSSLL		EENKVHADLV		ISKPVSKSPE		RLRKDIEVLS		EDTDYEEDEV
TKKRKDVKKD		TTDKSSKPQI		KRGKRRYCNT		EECLKTGSPG		KKEEKAKNKE
SLCMENSSNS		SSDEDEEETK		AKMTPTKKYN		GLEEKRKSLR		TTGFYSGFSE
VAEKRIKLLN		NSDERLQNSR		AKDRKDVWSS		IQGQWPKKTL		KELFSDSDTE
AAASPPHPAP		EEGVAEESLQ		TVAEEESCSP		SVELEKPPPV		NVDSKPIEEK
TVEVNDRKAE		FPSSGSNSVL		NTPPTTPESP		SSVTVTEGSR		QQSSVTVSEP
LAPNQEEVRS		IKSETDSTIE		VDSVAGELQD		LQSEGNSSPA		GFDASVSSSS
SNQPEPEHPE		KACTGQKRVK		DAQGGGSSSK		KQKRSHKATV		VNNKKKGKGT
NSSDSEELSA		GESITKSQPV		KSVSTGMKSH		STKSPARTQS		PGKCGKNGDK
DPDLKEPSNR		LPKVYKWSFQ		MSDLENMTSA		ERITILQEKL		QEIRKHYLSL
KSEVASIDRR		RKRLKKKERE		SAATSSSSSS		PSSSSITAAV		MLTLAEPSMS
SASQNGMSVE		CR

Funkcija

Ovaj gen kodira protein sa sekvencom sličnosti sa retinoblastom-vezujućim proteinom-1. Kodirani protein je podjedinica histon-deacetilaza-ovisnog SIN3A transkripcijskog korepresorskog kompleksa, koji funkcioniše u različitim ćelijskim procesima, uključujući proliferaciju ćelija, diferencijaciju, apoptozu, onkogenezu i određivanje ćelijske sudbine Genski proizvod prepoznaje antitijelo IgG izolirano od raka dojke pacijenta i čini se da je molekulski marker povezan sa širokim spektrom ljudskih maligniteta. Karakterizirane su alternativne transkripcijske prerađene varijante koje kodiraju različite izoforme.^[6]

Reference

1. GRCh38: Ensembl release 89: ENSG00000054267 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039219 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cao J, Gao T, Stanbridge EJ, Irie R (Aug 2001). "RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis". J Natl Cancer Inst. 93 (15): 1159–65. doi:10.1093/jnci/93.15.1159. PMID 11481388.
6. "Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)".
7. "UniProt, Q4LE39" (jezik: en.). Pristupljeno 7. 12. 2021.

Dopunska literatura

• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T, Sendtner M (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease". J. Cell Biol. 159 (4): 563–9. doi:10.1083/jcb.200208001. PMC 2173089. PMID 12446740.
• Fleischer TC, Yun UJ, Ayer DE (2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Mol. Cell. Biol. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
• Cui D, Jin G, Gao T, Sun T, Tian F, Estrada GG, Gao H, Sarai A (2004). "Characterization of BRCAA1 and its novel antigen epitope identification". Cancer Epidemiol. Biomarkers Prev. 13 (7): 1136–45. PMID 15247124.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

Vanjski linkovi

• Lokacija ljudskog genoma ARID4B i stranica sa detaljima o genu ARID4B u UCSC Genome Browseru.