AZIN2

AZIN2
Identifikatori
Aliasi	AZIN2
Vanjski ID-jevi	OMIM: 608353 MGI: 2442093 HomoloGene: 62172 GeneCards: AZIN2
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p35.1 Početak 33,081,104 bp[1] Kraj 33,123,492 bp[1]
Lokacija gena (miš) Hrom. Hromosom 4 (miš)[2] Bend 4|4 D2.2 Početak 128,824,026 bp[2] Kraj 128,856,235 bp[2]
Ontologija gena Molekularna funkcija • putrescine transmembrane transporter activity • catalytic activity • GO:0001948, GO:0016582 vezivanje za proteine • ornithine decarboxylase activator activity • arginine decarboxylase activity • ornithine decarboxylase activity Ćelijska komponenta • transport vesicle • citoplazma • mitohondrija • trans-Golđijeva mreža • projekcija ćelije • Golđijev aparat • jedro • Akson • granular vesicle • membrana • dendrit • perinuklearno područje citoplazme • cis-Golgi network • GO:0016023 citoplazmatska vezikula • perikaryon • endoplasmic reticulum-Golgi intermediate compartment membrane • endoplasmic reticulum-Golgi intermediate compartment • citosol Biološki proces • positive regulation of polyamine transmembrane transport • Spermatogeneza • putrescine transport • ornithine metabolic process • putrescine biosynthetic process from ornithine • trans-Golgi network membrane organization • agmatine biosynthetic process • GO:0048554 positive regulation of catalytic activity • polyamine biosynthetic process • GO:1903363 negative regulation of protein catabolic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	113451	242669
Ensembl	ENSG00000142920	ENSMUSG00000028789
UniProt	Q96A70	Q8BVM4
RefSeq (mRNK)	NM_001293562 NM_001301823 NM_001301824 NM_001301825 NM_001301826 NM_052998 NM_001350398 NM_001350399 NM_001350400 NM_001350401 NM_001350402 NM_001376722 NM_001376724 NM_001376725 NM_001376727 NM_001376729 NM_001376730 NM_001376732	NM_001301841 NM_172875
RefSeq (bjelančevina)	NP_001280491 NP_001288752 NP_001288753 NP_001288754 NP_001288755 NP_443724 NP_001337327 NP_001337328 NP_001337329 NP_001337330 NP_001337331 NP_001363651 NP_001363653 NP_001363654 NP_001363656 NP_001363658 NP_001363659 NP_001363661	NP_001288770 NP_766463
Lokacija (UCSC)	Chr 1: 33.08 – 33.12 Mb	Chr 4: 128.82 – 128.86 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Antizimski inhibitor 2 (AzI2) znan i kao arginin-dekarboksilaza (ADC) jest enzim koji je kod ljudi kodiran genom AZIN2 sa hromosoma 1. .^[5][6][7]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 460 aminokiselina, a molekulska težina 49.980 Da.^[8]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAGYLSESDF		VMVEEGFSTR		DLLKELTLGA		SQATTDEVAA		FFVADLGAIV
RKHFCFLKCL		PRVRPFYAVK		CNSSPGVLKV		LAQLGLGFSC		ANKAEMELVQ
HIGIPASKII		CANPCKQIAQ		IKYAAKHGIQ		LLSFDNEMEL		AKVVKSHPSA
KMVLCIATDD		SHSLSCLSLK		FGVSLKSCRH		LLENAKKHHV		EVVGVSFHIG
SGCPDPQAYA		QSIADARLVF		EMGTELGHKM		HVLDLGGGFP		GTEGAKVRFE
EIASVINSAL		DLYFPEGCGV		DIFAELGRYY		VTSAFTVAVS		IIAKKEVLLD
QPGREEENGS		TSKTIVYHLD		EGVYGIFNSV		LFDNICPTPI		LQKKPSTEQP
LYSSSLWGPA		VDGCDCVAEG		LWLPQLHVGD		WLVFDNMGAY		TVGMGSPFWG
TQACHITYAM		SRVAWEALRR		QLMAAEQEDD		VEGVCKPLSC		GWEITDTLCV
GPVFTPASIM

Reference

1. GRCh38: Ensembl release 89: ENSG00000142920 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028789 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pitkänen LT, Heiskala M, Andersson LC (2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochem. Biophys. Res. Commun. 287 (5): 1051–7. doi:10.1006/bbrc.2001.5703. PMID 11587527.
6. Zhu MY, Iyo A, Piletz JE, Regunathan S (2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochim. Biophys. Acta. 1670 (2): 156–64. doi:10.1016/j.bbagen.2003.11.006. PMC 3118518. PMID 14738999.
7. "Entrez Gene: ADC arginine decarboxylase".
8. "UniProt, Q96A70" (jezik: engleski). Pristupljeno 21. 11. 2021.

Dopunska literatura

• Nagase T, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
• Coleman CS, Hu G, Pegg AE (2004). "Putrescine biosynthesis in mammalian tissues". Biochem. J. 379 (Pt 3): 849–55. doi:10.1042/BJ20040035. PMC 1224126. PMID 14763899.
• Choi KS, Suh YH, Kim WH, Lee TH, Jung MH (2005). "Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity". Biochem. Biophys. Res. Commun. 328 (1): 206–12. doi:10.1016/j.bbrc.2004.11.172. PMID 15670771.
• López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity". J. Biol. Chem. 281 (41): 30896–906. doi:10.1074/jbc.M602840200. PMID 16916800.
• Tian H, Liu X, Zhang B, Sun Q, Sun D (2007). "Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth". Acta Biochim. Biophys. Sin. (Shanghai). 39 (6): 423–30. doi:10.1111/j.1745-7270.2007.00294.x. PMID 17558447.
• Levin VA, Jochec JL, Shantz LM, Aldape KD (2007). "Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy". Int. J. Cancer. 121 (10): 2279–83. doi:10.1002/ijc.22914. PMID 17582600.
• Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase". Biochem. J. 409 (1): 187–92. doi:10.1042/BJ20071004. PMID 17900240.

Vanjski linkovi

• Lokacija ljudskog genoma AZI2 i stranica sa detaljima o genu AZI2 u UCSC Genome Browseru.
• Lokacija ljudskog genoma AZIN2 i stranica sa detaljima o genu AZIN2 u UCSC Genome Browseru.