CASZ1

CASZ1
Identifikatori
Aliasi	CASZ1
Vanjski ID-jevi	OMIM: 609895 MGI: 1196251 HomoloGene: 9824 GeneCards: CASZ1
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p36.22 Početak 10,636,604 bp[1] Kraj 10,796,650 bp[1]
Lokacija gena (miš) Hrom. Hromosom 4 (miš)[2] Bend 4 E2|4 78.87 cM Početak 148,888,886 bp[2] Kraj 149,039,346 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje iona metala • vezivanje sa DNK • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • intracellular membrane-bounded organelle • nukleoplazma • citosol • jedro Biološki proces • multicellular organism development • GO:0009373 regulation of transcription, DNA-templated • regulation of neuron differentiation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	54897	69743
Ensembl	ENSG00000130940	ENSMUSG00000028977
UniProt	Q86V15	Q9CWL2
RefSeq (mRNK)	NM_001039183 NM_001079843 NM_017766	NM_001159344 NM_027195
RefSeq (bjelančevina)	NP_001073312 NP_060236	NP_001152816 NP_081471
Lokacija (UCSC)	Chr 1: 10.64 – 10.8 Mb	Chr 4: 148.89 – 149.04 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Pretpostavljeni protein vezan za preživljavanje jest protein koji je kod ljudi kodiran genom CASZ1 sa hromosoma 1.^[5][6]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 1.759 aminokiselina, a molekulska težina Da. 190 069^[7]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MDLGTAEGTR		CTDPPAGKPA		MAPKRKGGLK		LNAICAKLSR		QVVVEKRADA
GSHTEGSPSQ		PRDQERSGPE		SGAARAPRSE		EDKRRAVIEK		WVNGEYSEEP
APTPVLGRIA		REGLELPPEG		VYMVQPQGCS		DEEDHAEEPS		KDGGALEEKD
SDGAASKEDS		GPSTRQASGE		ASSLRDYAAS		TMTEFLGMFG		YDDQNTRDEL
ARKISFEKLH		AGSTPEAATS		SMLPTSEDTL		SKRARFSKYE		EYIRKLKAGE
QLSWPAPSTK		TEERVGKEVV		GTLPGLRLPS		STAHLETKAT		ILPLPSHSSV
QMQNLVARAS		KYDFFIQKLK		TGENLRPQNG		STYKKPSKYD		LENVKYLHLF
KPGEGSPDMG		GAIAFKTGKV		GRPSKYDVRG		IQKPGPAKVP		PTPSLAPAPL
ASVPSAPSAP		GPGPEPPASL		SFNTPEYLKS		TFSKTDSITT		GTVSTVKNGL
PTDKPAVTED		VNIYQKYIAR		FSGSQHCGHI		HCAYQYREHY		HCLDPECNYQ
RFTSKQDVIR		HYNMHKKRDN		SLQHGFMRFS		PLDDCSVYYH		GCHLNGKSTH
YHCMQVGCNK		VYTSTSDVMT		HENFHKKNTQ		LINDGFQRFR		ATEDCGTADC
QFYGQKTTHF		HCRRPGCTFT		FKNKCDIEKH		KSYHIKDDAY		AKDGFKKFYK
YEECKYEGCV		YSKATNHFHC		IRAGCGFTFT		STSQMTSHKR		KHERRHIRSS
GALGLPPSLL		GAKDTEHEES		SNDDLVDFSA		LSSKNSSLSA		SPTSQQSSAS
LAAATAATEA		GPSATKPPNS		KISGLLPQGL		PGSIPLALAL		SNSGLPTPTP
YFPILAGRGS		TSLPVGTPSL		LGAVSSGSAA		SATPDTPTLV		ASGAGDSAPV
AAASVPAPPA		SIMERISASK		GLISPMMARL		AAAALKPSAT		FDPGSGQQVT
PARFPPAQVK		PEPGESTGAP		GPHEASQDRS		LDLTVKEPSN		ESNGHAVPAN
SSLLSSLMNK		MSQGNPGLGS		LLNIKAEAEG		SPAAEPSPFL		GKAVKALVQE
KLAEPWKVYL		RRFGTKDFCD		GQCDFLHKAH		FHCVVEECGA		LFSTLDGAIK
HANFHFRTEG		GAAKGNTEAA		FPASAAETKP		PMAPSSPPVP		PVTTATVSSL
EGPAPSPASV		PSTPTLLAWK		QLASTIPQMP		QIPASVPHLP		ASPLATTSLE
NAKPQVKPGF		LQFQENDPCL		ATDCKYANKF		HFHCLFGNCK		YVCKTSGKAE
SHCLDHINPN		NNLVNVRDQF		AYYSLQCLCP		NQHCEFRMRG		HYHCLRTGCY
FVTNITTKLP		WHIKKHEKAE		RRAANGFKYF		TKREECGRLG		CKYNQVNSHF
HCIREGCQFS		FLLKHQMTSH		ARKHMRRMLG		KNFDRVPPSQ		GPPGLMDAET
DECMDYTGCS		PGAMSSESST		MDRSCSSTPV		GNESTAAGNT		ISMPTASGAK
KRFWIIEDMS		PFGKRRKTAS		SRKMLDEGMM		LEGFRRFDLY		EDCKDAACQF
SLKVTHYHCT		RENCGYKFCG		RTHMYKHAQH		HDRVDNLVLD		DFKRFKASLS
CHFADCPFSG		TSTHFHCLRC		RFRCTDSTKV		TAHRKHHGKQ		DVISAAGFCQ
FSSSADCAVP		DCKYKLKCSH		FHCTFPGCRH		TVVGMSQMDS		HKRKHEKQER
GEPAAEGPAP		GPPISLDGSL		SLGAEPGSLL		FLQSAAAGLG		LALGDAGDPG
PPDAAAPGPR		EGAAAAAAAA		GESSQEDEEE		ELELPEEEAE		DDEDEDDDED
DDDEDDDEDD		DDEDLRTDSE		ESLPEAAAEA		AGAGARTPAL		AALAALGAPG
PAPTAASSP

Reference

1. GRCh38: Ensembl release 89: ENSG00000130940 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028977 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liu Z, Yang X, Tan F, Cullion K, Thiele CJ (maj 2006). "Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation". Biochem Biophys Res Commun. 344 (3): 834–44. doi:10.1016/j.bbrc.2006.03.207. PMID 16631614.
6. "Entrez Gene: CASZ1 castor zinc finger 1".
7. "UniProt, Q86V15" (jezik: engleski). Pristupljeno 22. 11. 2021.

Dopunska literatura

• Fernandez F, Curtain RP, Colson NJ, et al. (2007). "Association analysis of chromosome 1 migraine candidate genes". BMC Med. Genet. 8: 57. doi:10.1186/1471-2350-8-57. PMC 2034370. PMID 17727731.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Yuan ZR, Wang R, Solomon J, et al. (2006). "Identification and characterization of survival-related gene, a novel cell survival gene controlling apoptosis and tumorigenesis". Cancer Res. 65 (23): 10716–24. doi:10.1158/0008-5472.CAN-05-2176. PMID 16322216.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Vanjski linkovi

• Lokacija ljudskog genoma CASZ1 i stranica sa detaljima o genu CASZ1 u UCSC Genome Browseru.