CSRP2

CSRP2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2CU8
Identifikatori
Aliasi	CSRP2
Vanjski ID-jevi	OMIM: 601871 MGI: 1202907 HomoloGene: 111061 GeneCards: CSRP2
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek)[1] Bend 12q21.2 Početak 76,858,709 bp[1] Kraj 76,879,023 bp[1]
Lokacija gena (miš) Hrom. Hromosom 10 (miš)[2] Bend 10|10 D1 Početak 110,755,650 bp[2] Kraj 110,775,483 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • molekularna funkcija • structural constituent of muscle • actinin binding Ćelijska komponenta • jedro • focal adhesion • citoplazma • Z discdkac Biološki proces • multicellular organism development • Ćelijska diferencijacija • actin cytoskeleton organization • sarcomere organization • muscle tissue development Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	1466	13008
Ensembl	ENSG00000175183	ENSMUSG00000020186
UniProt	Q16527	P97314
RefSeq (mRNK)	NM_001300965 NM_001321	NM_007792
RefSeq (bjelančevina)	NP_001287894 NP_001312	NP_031818
Lokacija (UCSC)	Chr 12: 76.86 – 76.88 Mb	Chr 10: 110.76 – 110.78 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Cisteinski i glicinski bogati protein 2 je protein koji je kod ljudi kodiran genom CSRP2.^[5]

CSRP2 je član porodice gena CSRP, kodirajući grupu proteina LIM domena, koji mogu biti uključeni u regulatorne procese važne za razvoj i ćelijsku diferencijaciju. CRP2 sadrži dvije kopije motiva sekvence aminokiselina bogate cisteinom (LIM) s navodnom aktivnošću vezanja cinka i može biti uključen u regulaciju uređenog ćelijskog rasta. Ostali geni u porodici uključuju CSRP1 i CSRP3.^[6][6][7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 193 aminokiseline, a molekulska težina 20.954 Da.^[8].

10		20		30		40		50
MPVWGGGNKC		GACGRTVYHA		EEVQCDGRSF		HRCCFLCMVC		RKNLDSTTVA
IHDEEIYCKS		CYGKKYGPKG		YGYGQGAGTL		NMDRGERLGI		KPESVQPHRP
TTNPNTSKFA		QKYGGAEKCS		RCGDSVYAAE		KIIGAGKPWH		KNCFRCAKCG
KSLESTTLTE		KEGEIYCKGC		YAKNFGPKGF		GYGQGAGALV		HAQ

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

1. GRCh38: Ensembl release 89: ENSG00000175183 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020186 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (Jan 1996). "The cysteine-rich protein family of highly related LIM domain proteins". J Biol Chem. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425.
6. "Entrez Gene: CSRP2 cysteine and glycine-rich protein 2".
7. Weiskirchen R, Erdel M, Utermann G, Bister K (Nov 1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics. 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703.
8. "UniProt, Q16527". Pristupljeno 8. 8. 2021.

Dopunska literatura

• Jain MK, Fujita KP, Hsieh CM, et al. (1996). "Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells". J. Biol. Chem. 271 (17): 10194–9. doi:10.1074/jbc.271.17.10194. PMID 8626582.
• Karim MA, Ohta K, Egashira M, et al. (1997). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798.
• Weiskirchen R, Gressner AM (2000). "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)". Biochem. Biophys. Res. Commun. 274 (3): 655–63. doi:10.1006/bbrc.2000.3187. PMID 10924333.
• Weiskirchen R, Moser M, Weiskirchen S, et al. (2001). "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1". Biochem. J. 359 (Pt 3): 485–96. doi:10.1042/0264-6021:3590485. PMC 1222169. PMID 11672422.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang M, Hu Y, Shima I, Stearns ME (2003). "IL-10/IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate tumor lines". Cancer Biol. Ther. 1 (5): 556–63. doi:10.4161/cbt.1.5.222. PMID 12496489.
• Stearns ME, Wang M, Hu Y, Garcia FU (2004). "Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines". Mol. Cancer Res. 1 (9): 631–42. PMID 12861049.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Vanjski linkovi

• Lokacija ljudskog genoma CSRP2 i stranica sa detaljima o genu CSRP2 u UCSC Genome Browseru.