FUT1

FUT1
Identifikatori
Aliasi	FUT1
Vanjski ID-jevi	OMIM: 211100 MGI: 109375 HomoloGene: 120 GeneCards: FUT1
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek)[1] Bend 19q13.33 Početak 48,748,011 bp[1] Kraj 48,755,390 bp[1]
Lokacija gena (miš) Hrom. Hromosom 7 (miš)[2] Bend 7 B3|7 29.39 cM Početak 45,266,713 bp[2] Kraj 45,270,483 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • aktivnost sa transferazom • galactoside 2-alpha-L-fucosyltransferase activity • fucosyltransferase activity • glycosyltransferase activity Ćelijska komponenta • integral component of membrane • Golgi cisterna membrane • Golđijev aparat • integral component of plasma membrane • membrana Biološki proces • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation • L-fucose catabolic process • fucosylation • carbohydrate metabolic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2523	14343
Ensembl	ENSG00000174951	ENSMUSG00000008461
UniProt	P19526	O09160
RefSeq (mRNK)	NM_000148 NM_001329877 NM_001384359	NM_001271981 NM_008051
RefSeq (bjelančevina)	NP_000139 NP_001316806	NP_001258910 NP_032077
Lokacija (UCSC)	Chr 19: 48.75 – 48.76 Mb	Chr 7: 45.27 – 45.27 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Galaktozid 2-alfa-L-fukoziltransferaza 1 je enzim koji je kod ljudi kodiran genom FUT1.^[5]

Ovaj enzim uključen je u sintezu antigena H.

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MWLRSHRQLC		LAFLLVCVLS		VIFFLHIHQD		SFPHGLGLSI		LCPDRRLVTP
PVAIFCLPGT		AMGPNASSSC		PQHPASLSGT		WTVYPNGRFG		NQMGQYATLL
ALAQLNGRRA		FILPAMHAAL		APVFRITLPV		LAPEVDSRTP		WRELQLHDWM
SEEYADLRDP		FLKLSGFPCS		WTFFHHLREQ		IRREFTLHDH		LREEAQSVLG
QLRLGRTGDR		PRTFVGVHVR		RGDYLQVMPQ		RWKGVVGDSA		YLRQAMDWFR
ARHEAPVFVV		TSNGMEWCKE		NIDTSQGDVT		FAGDGQEATP		WKDFALLTQC
NHTIMTIGTF		GFWAAYLAGG		DTVYLANFTL		PDSEFLKIFK		PEAAFLPEWV
GINADLSPLW		TLAKP

Reference

1. GRCh38: Ensembl release 89: ENSG00000174951 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008461 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)".

Dopunska literatura

• Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gérard G, Oriol R (juli 1991). "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Annals of Human Genetics. 55 (Pt 3): 225–33. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885. S2CID 30777695.
• Larsen RD, Ernst LK, Nair RP, Lowe JB (septembar 1990). "Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen". Proceedings of the National Academy of Sciences of the United States of America. 87 (17): 6674–8. doi:10.1073/pnas.87.17.6674. PMC 54599. PMID 2118655.
• Reguigne-Arnould I, Couillin P, Mollicone R, Fauré S, Fletcher A, Kelly RJ, Lowe JB, Oriol R (1995). "Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19". Cytogenetics and Cell Genetics. 71 (2): 158–62. doi:10.1159/000134098. PMID 7656588.
• Bruneau N, Lombardo D (juni 1995). "Chaperone function of a Grp 94-related protein for folding and transport of the pancreatic bile salt-dependent lipase". The Journal of Biological Chemistry. 270 (22): 13524–33. doi:10.1074/jbc.270.22.13524. PMID 7768954.
• Kelly RJ, Ernst LK, Larsen RD, Bryant JG, Robinson JS, Lowe JB (juni 1994). "Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals". Proceedings of the National Academy of Sciences of the United States of America. 91 (13): 5843–7. doi:10.1073/pnas.91.13.5843. PMC 44093. PMID 7912436.
• Koda Y, Soejima M, Kimura H (mart 1997). "Structure and expression of H-type GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase gene (FUT1). Two transcription start sites and alternative splicing generate several forms of FUT1 mRNA". The Journal of Biological Chemistry. 272 (11): 7501–5. doi:10.1074/jbc.272.11.7501. PMID 9054453.
• Wagner FF, Flegel WA (mart 1997). "Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles". Transfusion. 37 (3): 284–90. doi:10.1046/j.1537-2995.1997.37397240210.x. PMID 9122901.
• Kaneko M, Nishihara S, Shinya N, Kudo T, Iwasaki H, Seno T, Okubo Y, Narimatsu H (juli 1997). "Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals that inactivate H enzyme". Blood. 90 (2): 839–49. doi:10.1182/blood.V90.2.839. PMID 9226185.
• Koda Y, Soejima M, Johnson PH, Smart E, Kimura H (septembar 1997). "Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system". Biochemical and Biophysical Research Communications. 238 (1): 21–5. doi:10.1006/bbrc.1997.7232. PMID 9299444.
• Koda Y, Soejima M, Kimura H (septembar 1998). "Changing transcription start sites in H-type alpha(1,2)fucosyltransferase gene (FUT1) during differentiation of the human erythroid lineage". European Journal of Biochemistry / FEBS. 256 (2): 379–87. doi:10.1046/j.1432-1327.1998.2560379.x. PMID 9760178.
• Roos C, Kolmer M, Mattila P, Renkonen R (februar 2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". The Journal of Biological Chemistry. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.
• Yip SP, Chee KY, Chan PY, Chow EY, Wong HF (oktobar 2002). "Molecular genetic analysis of para-Bombay phenotypes in Chinese: a novel non-functional FUT1 allele is identified". Vox Sanguinis. 83 (3): 258–62. doi:10.1046/j.1423-0410.2002.00184.x. hdl:10397/32501. PMID 12366770.
• López-Ferrer A, de Bolós C (januar 2002). "The expression of human FUT1 in HT-29/M3 colon cancer cells instructs the glycosylation of MUC1 and MUC5AC apomucins". Glycoconjugate Journal. 19 (1): 13–21. doi:10.1023/A:1022576712961. PMID 12652076. S2CID 13065601.
• Shi S, Stanley P (april 2003). "Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways". Proceedings of the National Academy of Sciences of the United States of America. 100 (9): 5234–9. doi:10.1073/pnas.0831126100. PMC 154328. PMID 12697902.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (juni 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Guo ZH, Xiang D, Zhu ZY, Wang JL, Zhang JM, Liu X, Shen W, Chen HP (oktobar 2004). "[Analysis on FUT1 and FUT2 gene of 10 para-Bombay individuals in China]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 21 (5): 417–21. PMID 15476160.
• Yan L, Zhu F, Xu X, Hong X, Lv Q (maj 2005). "Molecular basis for para-Bombay phenotypes in Chinese persons, including a novel nonfunctional FUT1 allele". Transfusion. 45 (5): 725–30. doi:10.1111/j.1537-2995.2005.04305.x. PMID 15847661.
• Mejías-Luque R, López-Ferrer A, Garrido M, Fabra A, de Bolós C (juli 2007). "Changes in the invasive and metastatic capacities of HT-29/M3 cells induced by the expression of fucosyltransferase 1". Cancer Science. 98 (7): 1000–5. doi:10.1111/j.1349-7006.2007.00484.x. PMID 17459061. S2CID 24079329.

Vanjski linkovi