GBP5

GBP5
Identifikatori
Aliasi	GBP5
Vanjski ID-jevi	OMIM: 611467 MGI: 2429943 HomoloGene: 14183 GeneCards: GBP5
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p22.2 Početak 89,256,189 bp[1] Kraj 89,272,860 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3|3 H1 Početak 142,199,739 bp[2] Kraj 142,228,105 bp[2]
Ontologija gena Molekularna funkcija • nucleotide binding • GTP binding • GO:0001948, GO:0016582 vezivanje za proteine • hydrolase activity • GO:0006184 GTPase activity • vezivanje identičnih proteina • protein homodimerization activity Ćelijska komponenta • citoplazma • Golđijeva membrana • Golđijev aparat • membrana • GO:0016023 citoplazmatska vezikula • perinuklearno područje citoplazme Biološki proces • immune system process • positive regulation of cytokine production involved in inflammatory response • inflammatory response • positive regulation of NLRP3 inflammasome complex assembly • protein homotetramerization • positive regulation of innate immune response • cellular response to interferon-gamma • response to bacterium • protein localization to Golgi apparatus Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	115362	229898
Ensembl	ENSG00000154451	ENSMUSG00000105504
UniProt	Q96PP8	Q8CFB4
RefSeq (mRNK)	NM_052942 NM_001134486 NM_001391920	NM_153564 NM_212440
RefSeq (bjelančevina)	NP_001127958 NP_443174	NP_705792
Lokacija (UCSC)	Chr 1: 89.26 – 89.27 Mb	Chr 3: 142.2 – 142.23 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Gvanilat-vezujući protein 5 jest protein koji je kod ljudi kodiran genom GBP5 sa hromosoma 1.^[5]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 586 aminokiselina, a molekulska težina 66.617 Da.^[6].

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MALEIHMSDP		MCLIENFNEQ		LKVNQEALEI		LSAITQPVVV		VAIVGLYRTG
KSYLMNKLAG		KNKGFSVAST		VQSHTKGIWI		WCVPHPNWPN		HTLVLLDTEG
LGDVEKADNK		NDIQIFALAL		LLSSTFVYNT		VNKIDQGAID		LLHNVTELTD
LLKARNSPDL		DRVEDPADSA		SFFPDLVWTL		RDFCLGLEID		GQLVTPDEYL
ENSLRPKQGS		DQRVQNFNLP		RLCIQKFFPK		KKCFIFDLPA		HQKKLAQLET
LPDDELEPEF		VQQVTEFCSY		IFSHSMTKTL		PGGIMVNGSR		LKNLVLTYVN
AISSGDLPCI		ENAVLALAQR		ENSAAVQKAI		AHYDQQMGQK		VQLPMETLQE
LLDLHRTSER		EAIEVFMKNS		FKDVDQSFQK		ELETLLDAKQ		NDICKRNLEA
SSDYCSALLK		DIFGPLEEAV		KQGIYSKPGG		HNLFIQKTEE		LKAKYYREPR
KGIQAEEVLQ		KYLKSKESVS		HAILQTDQAL		TETEKKKKEA		QVKAEAEKAE
AQRLAAIQRQ		NEQMMQERER		LHQEQVRQME		IAKQNWLAEQ		QKMQEQQMQE
QAAQLSTTFQ		AQNRSLLSEL		QHAQRTVNND		DPCVLL

Također pogledajre

• Gvanilat, konjugirana baza gvanozin-monofosfata
• Gvanilat-vezujući protein

Reference

1. GRCh38: Ensembl release 89: ENSG00000154451 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000105504 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Guanylate binding protein 5". Pristupljeno 23. 1. 2013.
6. "UniProt, Q96PP8" (jezik: eng.). Pristupljeno 28. 11. 2021.