HLA-DPB1

HLA-DPB1
Dostupne strukture PDB Pretraga Human UniProta: PDBe RCSB Spisak PDB ID kodova 3LQZ, 4P4K, 4P4R, 4P57, 4P5K, 4P5M
Identifikatori
Aliasi	HLA-DPB1
Vanjski ID-jevi	OMIM: 142858 HomoloGene: 129927 GeneCards: HLA-DPB1
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek)[1] Bend 6p21.32 Početak 33,075,990 bp[1] Kraj 33,089,696 bp[1]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • peptide antigen binding Ćelijska komponenta • integral component of membrane • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane • endozom • Golđijev aparat • trans-Golgi network membrane • endoplasmic reticulum membrane • membrana • Golđijeva membrana • ćelijska membrana • transport vesicle membrane • MHC class II protein complex • cell surface • lysosomal membrane • Endoplazmatski retikulum • ER to Golgi transport vesicle membrane • Lizozom • integral component of lumenal side of endoplasmic reticulum membrane • endosome membrane Biološki proces • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class II • interferon-gamma-mediated signaling pathway • immune system process • T cell costimulation • positive regulation of interferon-gamma production • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • positive regulation of T cell activation • positive regulation of T cell proliferation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • T cell receptor signaling pathway • adaptive immune response Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3115	n/a
Ensembl	ENSG00000236693 ENSG00000230708 ENSG00000229295 ENSG00000226826 ENSG00000215048 ENSG00000223865 ENSG00000230763 ENSG00000237710	n/a
UniProt	P04440	n/a
RefSeq (mRNK)	NM_002121	n/a
RefSeq (bjelančevina)	NP_002112	n/a
Lokacija (UCSC)	Chr 6: 33.08 – 33.09 Mb	n/a
PubMed pretraga	[2]	n/a
Wikipodaci
Pogledaj/uredi – čovjek

DP(W2) beta lanac HLA klase II antigena histokompatibilnosti jest protein koji je kod ljudi kodiran genom HLA-DPB1 sa hromosoma 6.^[3]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 258 aminokiselina, a molekulska težina 29.159 Da.^[4]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MMVLQVSAAP		RTVALTALLM		VLLTSVVQGR		ATPENYLFQG		RQECYAFNGT
QRFLERYIYN		REEFARFDSD		VGEFRAVTEL		GRPAAEYWNS		QKDILEEKRA
VPDRMCRHNY		ELGGPMTLQR		RVQPRVNVSP		SKKGPLQHHN		LLVCHVTDFY
PGSIQVRWFL		NGQEETAGVV		STNLIRNGDW		TFQILVMLEM		TPQQGDVYTC
QVEHTSLDSP		VTVEWKAQSD		SARSKTLTGA		GGFVLGLIIC		GVGIFMHRRS
KKVQRGSA

Funkcija

HLA-DPB pripada paralozima beta lanca HLA klase II. Ova molekula klase II je heterodimer koji se sastoji od alfa (DPA) i beta lanca (DPB), oba usidrena u membrani. Ima centralnu ulogu u imunskom sistemu prezentirajući peptide izvedene iz vanćelijskih proteina. Molekule klase II eksprimiraju se u antigen-prezentirajučim ćelijama (APC: B-limfociti, dendritske ćelije, makrofagi). Beta-lanac je otprilike vlik 26-28 kDa i njegov gen sadrži šest egzona. Egzon 1 kodira vodeći peptid, egzoni 2 i 3 kodiraju dva vanćelijska domena, egzon 4 kodira transmembranski domen, a egzon 5 kodira citoplazmatski rep. Unutar DP molekula i alfa lanac i beta lanac sadrže polimorfizme koji određuju specifičnosti vezivanja peptida, što rezultira u do četiri različite molekule.^[4]

Također pogledajte

• Glavni kompleks histokompatibilnosti
• Ljudski leukocitni antigen
• HLA-DP

Reference

1. ENSG00000230708, ENSG00000229295, ENSG00000226826, ENSG00000215048, ENSG00000223865, ENSG00000230763, ENSG00000237710 GRCh38: Ensembl release 89: ENSG00000236693, ENSG00000230708, ENSG00000229295, ENSG00000226826, ENSG00000215048, ENSG00000223865, ENSG00000230763, ENSG00000237710 - Ensembl, maj 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: HLA-DPB1 major histocompatibility complex, class II, DP beta 1".
4. "UniProt, P04440" (jezik: engleski). Pristupljeno 6. 9. 2017.

Dopunska literatura

• Mitsunaga S, Kuwata S, Tokunaga K, et al. (1992). "Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two "new" alleles". Hum. Immunol. 34 (3): 203–11. doi:10.1016/0198-8859(92)90113-2. PMID 1358867.
• Marsh SG, Bodmer JG (1993). "HLA class II nucleotide sequences, 1992". Tissue Antigens. 40 (5): 229–43. doi:10.1111/j.1399-0039.1992.tb02050.x. PMID 1362295.
• Eiermann TH, Uhl S, Fakler J, Goldmann SF (1992). "A novel HLA-DPB1 sequence, DPB1*2301". Tissue Antigens. 40 (2): 108–10. doi:10.1111/j.1399-0039.1992.tb01969.x. PMID 1412416.
• Korioth F, Hartung K, Deicher H, Frey J (1992). "A new HLA-DPB1 allele from a patient with systemic lupus erythematosus". Tissue Antigens. 39 (4): 216–9. doi:10.1111/j.1399-0039.1992.tb01938.x. PMID 1529429.
• de Koster HS, Kenter MJ, D'Amaro J, et al. (1991). "Positive correlation between oligonucleotide typing and T-cell recognition of HLA-DP molecules". Immunogenetics. 34 (1): 12–22. doi:10.1007/BF00212307. PMID 1713190. S2CID 21845822.
• Vanderbeeken YE, Duchateau J, Colle H, et al. (1991). "Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated lymphocytes". Arch. Gynecol. Obstet. 248 (4): 199–209. doi:10.1007/BF02390359. PMID 1832848. S2CID 25184115.
• Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507.
• Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): 526–31. PMID 1967269.
• Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. doi:10.1073/pnas.87.22.9052. PMC 55099. PMID 1978941.
• Bugawan TL, Begovich AB, Erlich HA (1990). "Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes". Immunogenetics. 32 (4): 231–41. doi:10.1007/BF00187094. PMID 2242906. S2CID 39873046.
• Lair B, Alber C, Yu WY, et al. (1988). "A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity". J. Immunol. 141 (4): 1353–7. PMID 2456351.
• Bugawan TL, Horn GT, Long CM, et al. (1988). "Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci". J. Immunol. 141 (11): 4024–30. PMID 2460556.
• Begovich AB, Bugawan TL, Nepom BS, et al. (1990). "A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis". Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9489–93. doi:10.1073/pnas.86.23.9489. PMC 298522. PMID 2512583.
• Scholl P, Diez A, Mourad W, et al. (1989). "Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules". Proc. Natl. Acad. Sci. U.S.A. 86 (11): 4210–4. doi:10.1073/pnas.86.11.4210. PMC 287420. PMID 2542966.
• Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding". Nature. 339 (6225): 548–51. doi:10.1038/339548a0. PMID 2543930. S2CID 4246781.
• Lee JS, Sartoris S, Briata P, et al. (1989). "Sequence polymorphism of HLA-DP beta chains". Immunogenetics. 29 (5): 346–9. doi:10.1007/BF00352845. PMID 2714855. S2CID 13414587.
• Compagnone-Post P, Turco E, Robinson C, Trucco M (1988). "The beta-chains of DP4 molecules from different haplotypes are encoded by the same gene". Genomics. 2 (1): 8–13. doi:10.1016/0888-7543(88)90103-6. PMID 2838415.
• Diamond DC, Sleckman BP, Gregory T, et al. (1988). "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120". J. Immunol. 141 (11): 3715–7. PMID 2846691.
• Ando A, Inoko H, Kimura M, et al. (1987). "Isolation and allelic polymorphism of cDNA clones and genomic clones of HLA-DP heavy and light chains". Hum. Immunol. 17 (3): 355–67. doi:10.1016/0198-8859(86)90286-7. PMID 2878910.
• Kelly A, Trowsdale J (1985). "Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes". Nucleic Acids Res. 13 (5): 1607–21. doi:10.1093/nar/13.5.1607. PMC 341099. PMID 2987832.

Vanjski linkovi