HLA-DRB5

HLA-DRB5
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1FV1, 1H15, 1HQR, 1ZGL
Identifikatori
Aliasi	HLA-DRB5
Vanjski ID-jevi	OMIM: 604776 MGI: 95901 HomoloGene: 101524 GeneCards: HLA-DRB5
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek)[1] Bend 6p21.32 Početak 32,517,353 bp[1] Kraj 32,530,287 bp[1]
Lokacija gena (miš) Hrom. Hromosom 17 (miš)[2] Bend 17 B1|17 17.98 cM Početak 34,524,841 bp[2] Kraj 34,535,648 bp[2]
Ontologija gena Molekularna funkcija • peptide antigen binding Ćelijska komponenta • integral component of membrane • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane • endozom • Golđijev aparat • trans-Golgi network membrane • endoplasmic reticulum membrane • membrana • late endosome membrane • Golđijeva membrana • ćelijska membrana • transport vesicle membrane • MHC class II protein complex • lysosomal membrane • Endoplazmatski retikulum • ER to Golgi transport vesicle membrane • Lizozom • integral component of lumenal side of endoplasmic reticulum membrane • endosome membrane • Egzosom Biološki proces • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class II • interferon-gamma-mediated signaling pathway • immune system process • T cell costimulation • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • T cell receptor signaling pathway • adaptive immune response Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3127	14969
Ensembl	ENSG00000198502	ENSMUSG00000060586
UniProt	Q30154	P04231 P04230 P18468 P18469 O78196 n/a
RefSeq (mRNK)	NM_002125	NM_010382
RefSeq (bjelančevina)	NP_002116	NP_034512
Lokacija (UCSC)	Chr 6: 32.52 – 32.53 Mb	Chr 17: 34.52 – 34.54 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

DRB5 beta lanac HLA klase II antigena histokompatibilnosti jest protein koji je kod ljudi kodiran genom sa hromosoma 6.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 266 aminokiselina, a molekulska težina 30.056 Da.^[5]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MVCLKLPGGS		YMAKLTVTLM		VLSSPLALAG		DTRPRFLQQD		KYECHFFNGT
ERVRFLHRDI		YNQEEDLRFD		SDVGEYRAVT		ELGRPDAEYW		NSQKDFLEDR
RAAVDTYCRH		NYGVGESFTV		QRRVEPKVTV		YPARTQTLQH		HNLLVCSVNG
FYPGSIEVRW		FRNSQEEKAG		VVSTGLIQNG		DWTFQTLVML		ETVPRSGEVY
TCQVEHPSVT		SPLTVEWRAQ		SESAQSKMLS		GVGGFVLGLL		FLGAGLFIYF
KNQKGHSGLH		PTGLVS

Funkcija

Protein kodiran ovim genom pripada HLA klasi II beta lanca paraloga. Molekula klase II je heterodimer koji se sastoji od alfa (DRA) i beta lanca (DRB), oba usidrena u membrani. Ima centralnu ulogu u imunskom sistemu prezentirajući peptide izvedene iz vanćelijskih proteina. Molekule klase II ekspimirane su u ćelijama koje prezentiraju antigen (APC: B limfociti, dendritske ćelije, makrofagi).^[5]

Struktura gena i polimorfizmi

Beta lanac velik je otprilike 26-28 kDa. Kodira ga šest egzona; egzon 1 kodira vodeći peptid, egzoni 2 i 3 kodiraju dva vanćelijska domena, egzon 4 kodira transmembranski domen i egzon 5 kodira citoplazmaatski rep. Unutar DR molekula, beta lanac sadrži sve polimorfizme koji određuju specifičnosti vezivanja peptida. Opisane su stotine DRB1 alela i tipizacija za ove polimorfizme radi se rutinski za transplantaciju koštane srži i bubrega.^[5]

Ekspresija gena

DRB1 eksprimiran je na nivou pet puta većem od njegovih paraloga DRB3, DRB4 i DRB5. DRB1 je prisutan kod svih osoba. Alelne varijante DRB1 nisu povezane ni sa jednim ili sa jednim od gena DRB3, DRB4 i DRB5. Prisustvo DRB5 je povezano sa alelnim varijantama DRB1, inače se izostavlja. Postoje četiri srodna pseudogena: DRB2, DRB6, DRB7, DRB8 i DRB9.^[5]

Također pogledajte

• HLA-DR

Reference

1. GRCh38: Ensembl release 89: ENSG00000198502 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060586 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: HLA-DRB5 major histocompatibility complex, class II, DR beta 5".

Dopunska literatura

• Lau M, Terasaki PI, Park MS (1995). "International Cell Exchange, 1994". Clinical Transplants: 467–88. PMID 7547576.
• Dong RP, Kimura A, Sasazuki T (1992). "Sequence analysis of three novel DRw14-DRB1 alleles". Immunogenetics. 36 (2): 130–3. doi:10.1007/BF00215291. PMID 1612646. S2CID 32928324.
• Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507.
• Nong Y, Kandil O, Tobin EH, et al. (1991). "The HIV core protein p24 inhibits interferon-gamma-induced increase of HLA-DR and cytochrome b heavy chain mRNA levels in the human monocyte-like cell line THP1". Cell. Immunol. 132 (1): 10–6. doi:10.1016/0008-8749(91)90002-S. PMID 1905983.
• Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): 526–31. PMID 1967269.
• Callahan KM, Fort MM, Obah EA, et al. (1990). "Genetic variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor". J. Immunol. 144 (9): 3341–6. PMID 1970352.
• Petersdorf EW, Griffith RL, Erlich HA, et al. (1990). "Unique sequences for two HLA-DRB1 genes expressed on distinct DRw6 haplotypes". Immunogenetics. 32 (2): 96–103. doi:10.1007/BF00210446. PMID 1975801. S2CID 28007432.
• Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. doi:10.1073/pnas.87.22.9052. PMC 55099. PMID 1978941.
• Gyllensten UB, Sundvall M, Erlich HA (1991). "Allelic diversity is generated by intraexon sequence exchange at the DRB1 locus of primates". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3686–90. Bibcode:1991PNAS...88.3686G. doi:10.1073/pnas.88.9.3686. PMC 51517. PMID 2023919.
• Lee KW, Johnson AH, Hurley CK (1990). "Two divergent routes of evolution gave rise to the DRw13 haplotypes". J. Immunol. 145 (9): 3119–25. PMID 2212675.
• Gorski J (1989). "HLA-DR beta-chain polymorphism. Second domain polymorphism reflects evolutionary relatedness of alleles and may explain public serologic epitopes". J. Immunol. 143 (1): 329–33. PMID 2471740.
• Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding". Nature. 339 (6225): 548–51. Bibcode:1989Natur.339..548C. doi:10.1038/339548a0. PMID 2543930. S2CID 4246781.
• Hurley CK, Gregersen PK, Gorski J, et al. (1989). "The DR3(w18),DQw4 haplotype differs from DR3(w17),DQw2 haplotypes at multiple class II loci". Hum. Immunol. 25 (1): 37–50. doi:10.1016/0198-8859(89)90068-2. PMID 2565895.
• Diamond DC, Sleckman BP, Gregory T, et al. (1988). "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120". J. Immunol. 141 (11): 3715–7. PMID 2846691.
• Freeman SM, Saunders TL, Madden M, et al. (1987). "Comparison of DR beta 1 alleles from diabetic and normal individuals". Hum. Immunol. 19 (1): 1–6. doi:10.1016/0198-8859(87)90033-4. PMID 2884201.
• Lee BS, Rust NA, McMichael AJ, McDevitt HO (1987). "HLA-DR2 subtypes form an additional supertypic family of DR beta alleles". Proc. Natl. Acad. Sci. U.S.A. 84 (13): 4591–5. Bibcode:1987PNAS...84.4591L. doi:10.1073/pnas.84.13.4591. PMC 305136. PMID 2885840.
• Owerbach D, Rich C, Taneja K (1986). "Characterization of three HLA-DR beta genes isolated from an HLA-DR 3/4 insulin-dependent diabetic patient". Immunogenetics. 24 (1): 41–6. doi:10.1007/BF00372296. PMID 3015788. S2CID 19599710.
• Wu S, Saunders TL, Bach FH (1987). "Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR beta loci". Nature. 324 (6098): 676–9. doi:10.1038/324676a0. PMID 3099214. S2CID 4365990.
• Liu CP, Bach FH, Wu SK (1988). "Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes". J. Immunol. 140 (10): 3631–9. PMID 3129499.
• Steimle V, Hinkkanen A, Schlesier M, Epplen JT (1988). "A novel HLA-DR beta I sequence from the DRw11 haplotype". Immunogenetics. 28 (3): 208–10. doi:10.1007/BF00375861. PMID 3137159. S2CID 2712069.

Vanjski linkovi