Ovaj gen kodira člana porodice koštanomorfogenetskih proteina koja je dio natporodice transformirajućih faktora rasta beta. Natporodica uključuje velike porodice faktora rasta i diferencijacije. Koštanomorfogenetski proteini su prvobitno identifikovani sposobnošću demineralizovanog koštanog ekstrakta da indukuje endohrskavičnu osteogenezu in vivo na vanskeletnom mjestu. Ovi proteini sintetiziraju se kao prepropeptidi, cijepaju, a zatim procesuiraju u dimerne proteine. Može djelovati kao važna signalna molekula unutar trabekulske mreže i glave optičkog živca i imati potencijalnu ulogu u patogenezi glaukoma. Ovaj gen je različito regulisan tokom formiranja raznih tumora.[7]
Sakaue M, Kitazawa S, Nishida K, Kitazawa R, Maeda S (Apr 1996). "Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter". Biochemical and Biophysical Research Communications. 221 (3): 768–72. doi:10.1006/bbrc.1996.0671. PMID8630036.
Imai N, Iwai A, Hatakeyama S, Matsuzaki K, Kitagawa Y, Kato S, Hokari R, Kawaguchi A, Nagao S, Miyahara T, Itoh K, Miura S (Aug 2001). "Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification". Pathology International. 51 (8): 643–8. doi:10.1046/j.1440-1827.2001.01243.x. PMID11564221. S2CID35052100.
Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL (Oct 2001). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histology and Histopathology. 16 (4): 1013–9. PMID11642720.
Cohen A, Mulas R, Seri M, Gaiero A, Fichera G, Marini M, Baffico M, Camera G (Jan 2002). "Meier-Gorlin syndrome (ear-patella-short stature syndrome) in an Italian patient: clinical evaluation and analysis of possible candidate genes". American Journal of Medical Genetics. 107 (1): 48–51. doi:10.1002/ajmg.10083. PMID11807867.
Jiang FX, Stanley EG, Gonez LJ, Harrison LC (Feb 2002). "Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells". Journal of Cell Science. 115 (Pt 4): 753–60. doi:10.1242/jcs.115.4.753. PMID11865031.
Luo J, Dunn T, Ewing C, Sauvageot J, Chen Y, Trent J, Isaacs W (maj 2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis". The Prostate. 51 (3): 189–200. doi:10.1002/pros.10087. PMID11967953. S2CID42730702.
Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W, Clark AF (Jul 2002). "Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues". Molecular Vision. 8: 241–50. PMID12131877.
Xu WP, Shiba H, Mizuno N, Uchida Y, Mouri Y, Kawaguchi H, Kurihara H (2005). "Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells". Cell Biology International. 28 (10): 675–82. doi:10.1016/j.cellbi.2004.06.004. PMID15516325. S2CID45261710.
Bobinac D, Marić I, Zoricić S, Spanjol J, Dordević G, Mustać E, Fuckar Z (Jun 2005). "Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer". Croatian Medical Journal. 46 (3): 389–96. PMID15861517.