LHX9

LHX9
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2DMQ
Identifikatori
Aliasi	LHX9
Vanjski ID-jevi	OMIM: 606066 MGI: 1316721 HomoloGene: 7816 GeneCards: LHX9
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1q31.3 Početak 197,911,902 bp[1] Kraj 197,935,478 bp[1]
Lokacija gena (miš) Hrom. Hromosom 1 (miš)[2] Bend 1|1 E4 Početak 138,825,186 bp[2] Kraj 138,848,577 bp[2]
Ontologija gena Molekularna funkcija • sequence-specific DNA binding • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001106 transcription corepressor activity • vezivanje iona metala • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II transcription regulatory region sequence-specific DNA binding Ćelijska komponenta • jedro Biološki proces • Ćelijska proliferacija • male gonad development • GO:0045996 negative regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • female gonad development • gonad morphogenesis • dorsal spinal cord interneuron anterior axon guidance • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • neuron differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	56956	16876
Ensembl	ENSG00000143355	ENSMUSG00000019230
UniProt	Q9NQ69	Q9WUH2
RefSeq (mRNK)	NM_001014434 NM_020204 NM_001370213	NM_001025565 NM_001042577 NM_010714
RefSeq (bjelančevina)	NP_001014434 NP_064589 NP_001357142	NP_001020736 NP_001036042 NP_034844
Lokacija (UCSC)	Chr 1: 197.91 – 197.94 Mb	Chr 1: 138.83 – 138.85 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

LIM-homeoboks 9 jest protein koji je kod ljudi kodiran genom LHX9 sa hromosoma 1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 397 aminokiselina, a molekulska težina 43.976 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MEIVGCRAED		NSCPFRPPAM		LFHGISGGHI		QGIMEEMERR		SKTEARLAKG
AQLNGRDAGM		PPLSPEKPAL		CAGCGGKISD		RYYLLAVDKQ		WHLRCLKCCE
CKLALESELT		CFAKDGSIYC		KEDYYRRFSV		QRCARCHLGI		SASEMVMRAR
DSVYHLSCFT		CSTCNKTLTT		GDHFGMKDSL		VYCRAHFETL		LQGEYPPQLS
YTELAAKSGG		LALPYFNGTG		TVQKGRPRKR		KSPALGVDIV		NYNSGCNENE
ADHLDRDQQP		YPPSQKTKRM		RTSFKHHQLR		TMKSYFAINH		NPDAKDLKQL
AQKTGLTKRV		LQVWFQNARA		KFRRNLLRQE		NGGVDKADGT		SLPAPPSADS
GALTPPGTAT		TLTDLTNPTI		TVVTSVTSNM		DSHESGSPSQ		TTLTNLF

Funkcija

Ovaj gen kodira člana porodice gena LIM-homeoboksa razvojno eksprimiranih transkripcijskih faktoraa. Kodirani protein sadrži homeodomen i dva LIM-domena koji se vezuju za cistein, uključene u interakcije protein-protein. Protein je vrlo sličan proteinu miša koji uzrokuje agenezu gonada kada je inaktiviran, što ukazuje na ulogu u razvoju gonada. Alternativna prerada rezultira višestrukim varijantama transkripta.

Reference

1. GRCh38: Ensembl release 89: ENSG00000143355 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019230 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: LIM homeobox 9".
6. "UniProt, Q9NQ69" (jezik: engleski). Pristupljeno 13. 12. 2021.

Dopunska literatura

• Avraham O, Hadas Y, Vald L, Zisman S, Schejter A, Visel A, Klar A (2009). "Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1". Neural Dev. 4: 21. doi:10.1186/1749-8104-4-21. PMC 2704203. PMID 19545367.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.