Mitogen-aktivirana protein-kinaza 12 (MAP-kinaza 12), znana i kao vanćeliskim signalom regulirana kinaza 6 (ERK6) ili stresno aktivirana protein kinaza 3 (SAPK3), jest enzim koji je kod ljudi kodiran genom MAPK12 sa hromosoma 22 .[ 5]
Dužina polipeptidnog lanca je 367 aminokiselina , a molekulska težina 41.940 Da .[ 5]
10 20 30 40 50
MSSPPPARSG FYRQEVTKTA WEVRAVYRDL QPVGSGAYGA VCSAVDGRTG
AKVAIKKLYR PFQSELFAKR AYRELRLLKH MRHENVIGLL DVFTPDETLD
DFTDFYLVMP FMGTDLGKLM KHEKLGEDRI QFLVYQMLKG LRYIHAAGII
HRDLKPGNLA VNEDCELKIL DFGLARQADS EMTGYVVTRW YRAPEVILNW
MRYTQTVDIW SVGCIMAEMI TGKTLFKGSD HLDQLKEIMK VTGTPPAEFV
QRLQSDEAKN YMKGLPELEK KDFASILTNA SPLAVNLLEK MLVLDAEQRV
TAGEALAHPY FESLHDTEDE PQVQKYDDSF DDVDRTLDEW KRVTYKEVLS
FKPPRQLGAR VSKETPL
Aktivacija članova porodice mitogen-aktiviranih protein kinaza je glavni mehanizam za transdukciju vanćelijskih signala. Proteinske kinaze aktivirane stresom su jedna potklasa MAP-kinaza. Protein kodiran ovim genom funkcionira kao pretvarač signala tokom diferencijacije mioblasta u miotube .[ 5]
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Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država , koji je u javnom vlasništvu .