MSTO1

MSTO1
Identifikatori
Aliasi	MSTO1
Vanjski ID-jevi	OMIM: 617619 MGI: 2385175 HomoloGene: 41228 GeneCards: MSTO1
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1q22 Početak 155,610,205 bp[1] Kraj 155,614,951 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3|3 F1 Početak 88,812,414 bp[2] Kraj 88,821,306 bp[2]
Ontologija gena Molekularna funkcija • molekularna funkcija Ćelijska komponenta • mitochondrial outer membrane • mitohondrija • membrana • citoplazma Biološki proces • mitochondrion organization • mitochondrion distribution • mitochondrial genome maintenance • mitotic sister chromatid segregation • mitotic spindle assembly Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	55154	229524
Ensembl	ENSG00000125459	ENSMUSG00000068922
UniProt	Q9BUK6	Q2YDW2
RefSeq (mRNK)	NM_001256532 NM_001256533 NM_018116 NM_001350772 NM_001350773 NM_001350774 NM_001350775 NM_001350776 NM_001350777 NM_001350778 NM_001350779 NM_001350780 NM_001350781 NM_001350782 NM_001350783 NM_001350784 NM_001350785 NM_001350786 NM_001350787 NM_001350788 NM_001350789	NM_144898
RefSeq (bjelančevina)	NP_001243461 NP_001243462 NP_060586 NP_001337701 NP_001337702 NP_001337703 NP_001337704 NP_001337705 NP_001337706 NP_001337707 NP_001337708 NP_001337709 NP_001337710 NP_001337711 NP_001337712 NP_001337713 NP_001337714 NP_001337715 NP_001337716 NP_001337717 NP_001337718	NP_659147
Lokacija (UCSC)	Chr 1: 155.61 – 155.61 Mb	Chr 3: 88.81 – 88.82 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Proteinski misato homolog 1 jest protein koji je kod ljudi kodiran genom MSTO1 sa hromosoma 1.^[5][6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 570 aminokiselina, a molekulska težina 61.835 Da.^[7]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAGGAREVLT		LQLGHFAGFV		GAHWWNQQDA		ALGRATDSKE		PPGELCPDVL
YRTGRTLHGQ		ETYTPRLILM		DLKGSLSSLK		EEGGLYRDKQ		LDAAIAWQGK
LTTHKEELYP		KNPYLQDFLS		AEGVLSSDGV		WRVKSIPNGK		GSSPLPTATT
PKPLIPTEAS		IRVWSDFLRV		HLHPRSICMI		QKYNHDGEAG		RLEAFGQGES
VLKEPKYQEE		LEDRLHFYVE		ECDYLQGFQI		LCDLHDGFSG		VGAKAAELLQ
DEYSGRGIIT		WGLLPGPYHR		GEAQRNIYRL		LNTAFGLVHL		TAHSSLVCPL
SLGGSLGLRP		EPPVSFPYLH		YDATLPFHCS		AILATALDTV		TVPYRLCSSP
VSMVHLADML		SFCGKKVVTA		GAIIPFPLAP		GQSLPDSLMQ		FGGATPWTPL
SACGEPSGTR		CFAQSVVLRG		IDRACHTSQL		TPGTPPPSAL		HACTTGEEIL
AQYLQQQQPG		VMSSSHLLLT		PCRVAPPYPH		LFSSCSPPGM		VLDGSPKGAA
VESIPVFGAL		CSSSSLHQTL		EALARDLTKL		DLRRWASFMD		AGVEHDDVAE
LLQELQSLAQ		CYQGGDSLVD

Struktura

MSTO1 gen ima 5134 para baza (lociranih u hromosomu 1), a MSTO1 protein je dug 570 aminokiselina. Nalazi se u vanjskoj membrani mitohondrija i uključen je u regulaciju mitohondrijske distribucije i morfologije.^[8]

Protein misato sadrži N-terminalni miozinski domen sličan misato segmentu II i centralni domen tubulina.^[8]

Reference

1. GRCh38: Ensembl release 89: ENSG00000125459 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068922 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kuryshev VY, Vorobyov E, Zink D, Schmitz J, Rozhdestvensky TS, Munstermann E, Ernst U, Wellenreuther R, Moosmayer P, Bechtel S, Schupp I, Horst J, Korn B, Poustka A, Wiemann S (Jul 2006). "An anthropoid-specific segmental duplication on human chromosome 1q22". Genomics. 88 (2): 143–51. doi:10.1016/j.ygeno.2006.02.002. PMID 16545939.
6. "Entrez Gene: MSTO1 misato homolog 1 (Drosophila)".
7. "UniProt, Q9BUK6" (jezik: engleski). Pristupljeno 14. 12. 2021.
8. Kimura M, Okano Y (april 2007). "Human Misato regulates mitochondrial distribution and morphology". Exp. Cell Res. 313 (7): 1393–404. doi:10.1016/j.yexcr.2007.02.004. PMID 17349998.

Dopunska literatura

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Miklos GL, Yamamoto M, Burns RG, Maleszka R (1997). "An essential cell division gene of Drosophila, absent from Saccharomyces, encodes an unusual protein with tubulin-like and myosin-like peptide motifs". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5189–94. Bibcode:1997PNAS...94.5189M. doi:10.1073/pnas.94.10.5189. PMC 24654. PMID 9144213.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.