NOTCH2

NOTCH2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2OO4
Identifikatori
Aliasi	NOTCH2
Vanjski ID-jevi	OMIM: 600275 MGI: 97364 HomoloGene: 7865 GeneCards: NOTCH2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	120,100,779 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	98,057,677 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• calcium ion binding; • GO:0001948, GO:0016582 vezivanje za proteine; • signaling receptor activity;
Ćelijska komponenta	• citoplazma; • integral component of membrane; • endoplasmic reticulum membrane; • membrana; • Golđijeva membrana; • receptor complex; • ćelijska membrana; • integral component of plasma membrane; • nukleoplazma; • extracellular region; • cell surface; • jedro;
Biološki proces	• Notch signaling pathway; • Ćelijska diferencijacija; • Hematopoeza; • pulmonary valve morphogenesis; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of Ras protein signal transduction; • negative regulation of apoptotic process; • marginal zone B cell differentiation; • transcription, DNA-templated; • nervous system development; • stem cell population maintenance; • multicellular organism development; • atrial septum morphogenesis; • GO:0090343, GO:0090342 regulation of developmental process; • bone remodeling; • animal organ morphogenesis; • transcription initiation from RNA polymerase II promoter; • Notch signaling involved in heart development; • GO:0097285 apoptoza; • cell fate determination; • intracellular receptor signaling pathway; • negative regulation of gene expression; • negative regulation of growth rate; • positive regulation of ERK1 and ERK2 cascade; • regulation of osteoclast development; • positive regulation of keratinocyte proliferation; • regulation of actin cytoskeleton reorganization;
	Izvori:Amigo / QuickGO
Ortolozi
	4853
	18129
	ENSG00000134250
	ENSMUSG00000027878
	Q04721
	O35516
	NM_001200001; NM_024408
	NM_010928
	NP_001186930; NP_077719
	NP_035058
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Homologni protein 2 neurogenog lokusa notch znan i kao notch 2 jest protein koji je kod ljudi kodiran genom NOTCH2 sa hromosoma 1.^[5]

NOTCH2 vezan je za Alagilleov^[6] i Hajdu-Cheneyev sindrom.^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 2.471 aminokiselina, a molekulska težina 265.405 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPALRPALLW	ALLALWLCCA	APAHALQCRD	GYEPCVNEGM	CVTYHNGTGY
CKCPEGFLGE	YCQHRDPCEK	NRCQNGGTCV	AQAMLGKATC	RCASGFTGED
CQYSTSHPCF	VSRPCLNGGT	CHMLSRDTYE	CTCQVGFTGK	ECQWTDACLS
HPCANGSTCT	TVANQFSCKC	LTGFTGQKCE	TDVNECDIPG	HCQHGGTCLN
LPGSYQCQCP	QGFTGQYCDS	LYVPCAPSPC	VNGGTCRQTG	DFTFECNCLP
GFEGSTCERN	IDDCPNHRCQ	NGGVCVDGVN	TYNCRCPPQW	TGQFCTEDVD
ECLLQPNACQ	NGGTCANRNG	GYGCVCVNGW	SGDDCSENID	DCAFASCTPG
STCIDRVASF	SCMCPEGKAG	LLCHLDDACI	SNPCHKGALC	DTNPLNGQYI
CTCPQGYKGA	DCTEDVDECA	MANSNPCEHA	GKCVNTDGAF	HCECLKGYAG
PRCEMDINEC	HSDPCQNDAT	CLDKIGGFTC	LCMPGFKGVH	CELEINECQS
NPCVNNGQCV	DKVNRFQCLC	PPGFTGPVCQ	IDIDDCSSTP	CLNGAKCIDH
PNGYECQCAT	GFTGVLCEEN	IDNCDPDPCH	HGQCQDGIDS	YTCICNPGYM
GAICSDQIDE	CYSSPCLNDG	RCIDLVNGYQ	CNCQPGTSGV	NCEINFDDCA
SNPCIHGICM	DGINRYSCVC	SPGFTGQRCN	IDIDECASNP	CRKGATCING
VNGFRCICPE	GPHHPSCYSQ	VNECLSNPCI	HGNCTGGLSG	YKCLCDAGWV
GINCEVDKNE	CLSNPCQNGG	TCDNLVNGYR	CTCKKGFKGY	NCQVNIDECA
SNPCLNQGTC	FDDISGYTCH	CVLPYTGKNC	QTVLAPCSPN	PCENAAVCKE
SPNFESYTCL	CAPGWQGQRC	TIDIDECISK	PCMNHGLCHN	TQGSYMCECP
PGFSGMDCEE	DIDDCLANPC	QNGGSCMDGV	NTFSCLCLPG	FTGDKCQTDM
NECLSEPCKN	GGTCSDYVNS	YTCKCQAGFD	GVHCENNINE	CTESSCFNGG
TCVDGINSFS	CLCPVGFTGS	FCLHEINECS	SHPCLNEGTC	VDGLGTYRCS
CPLGYTGKNC	QTLVNLCSRS	PCKNKGTCVQ	KKAESQCLCP	SGWAGAYCDV
PNVSCDIAAS	RRGVLVEHLC	QHSGVCINAG	NTHYCQCPLG	YTGSYCEEQL
DECASNPCQH	GATCSDFIGG	YRCECVPGYQ	GVNCEYEVDE	CQNQPCQNGG
TCIDLVNHFK	CSCPPGTRGL	LCEENIDDCA	RGPHCLNGGQ	CMDRIGGYSC
RCLPGFAGER	CEGDINECLS	NPCSSEGSLD	CIQLTNDYLC	VCRSAFTGRH
CETFVDVCPQ	MPCLNGGTCA	VASNMPDGFI	CRCPPGFSGA	RCQSSCGQVK
CRKGEQCVHT	ASGPRCFCPS	PRDCESGCAS	SPCQHGGSCH	PQRQPPYYSC
QCAPPFSGSR	CELYTAPPST	PPATCLSQYC	ADKARDGVCD	EACNSHACQW
DGGDCSLTME	NPWANCSSPL	PCWDYINNQC	DELCNTVECL	FDNFECQGNS
KTCKYDKYCA	DHFKDNHCDQ	GCNSEECGWD	GLDCAADQPE	NLAEGTLVIV
VLMPPEQLLQ	DARSFLRALG	TLLHTNLRIK	RDSQGELMVY	PYYGEKSAAM
KKQRMTRRSL	PGEQEQEVAG	SKVFLEIDNR	QCVQDSDHCF	KNTDAAAALL
ASHAIQGTLS	YPLVSVVSES	LTPERTQLLY	LLAVAVVIIL	FIILLGVIMA
KRKRKHGSLW	LPEGFTLRRD	ASNHKRREPV	GQDAVGLKNL	SVQVSEANLI
GTGTSEHWVD	DEGPQPKKVK	AEDEALLSEE	DDPIDRRPWT	QQHLEAADIR
RTPSLALTPP	QAEQEVDVLD	VNVRGPDGCT	PLMLASLRGG	SSDLSDEDED
AEDSSANIIT	DLVYQGASLQ	AQTDRTGEMA	LHLAARYSRA	DAAKRLLDAG
ADANAQDNMG	RCPLHAAVAA	DAQGVFQILI	RNRVTDLDAR	MNDGTTPLIL
AARLAVEGMV	AELINCQADV	NAVDDHGKSA	LHWAAAVNNV	EATLLLLKNG
ANRDMQDNKE	ETPLFLAARE	GSYEAAKILL	DHFANRDITD	HMDRLPRDVA
RDRMHHDIVR	LLDEYNVTPS	PPGTVLTSAL	SPVICGPNRS	FLSLKHTPMG
KKSRRPSAKS	TMPTSLPNLA	KEAKDAKGSR	RKKSLSEKVQ	LSESSVTLSP
VDSLESPHTY	VSDTTSSPMI	TSPGILQASP	NPMLATAAPP	APVHAQHALS
FSNLHEMQPL	AHGASTVLPS	VSQLLSHHHI	VSPGSGSAGS	LSRLHPVPVP
ADWMNRMEVN	ETQYNEMFGM	VLAPAEGTHP	GIAPQSRPPE	GKHITTPREP
LPPIVTFQLI	PKGSIAQPAG	APQPQSTCPP	AVAGPLPTMY	QIPEMARLPS
VAFPTAMMPQ	QDGQVAQTIL	PAYHPFPASV	GKYPTPPSQH	SYASSNAAER
TPSHSGHLQG	EHPYLTPSPE	SPDQWSSSSP	HSASDWSDVT	TSPTPGGAGG
GQRGPGTHMS	EPPHNNMQVY	A

Funkcija

Notch 2 je član porodice notch. Članovi ove porodice transmembranskih proteina tipa 1 dijele strukturne karakteristike, uključujući vanćelijski domen koji se sastoji od višestrukih ponavljanja sličnih epidermnim faktorima rasta (EGF) i unutarćelijski domen koji se sastoji od više različitih tipova domena. Članovi porodice Notch imaju ulogu u raznim razvojnim procesima, kontrolišućirješenja o sudbini ćelije. Notch signalna mreža je evolucijski konzervirani međućelijski signalni put koji regulira interakcije između fizički susjednih ćelija. Kod Drosophila, interakcija Notch-a sa svojim ćelijskim ligandima (delta, serat) uspostavlja međućelijski signalni put koji ima ključnu ulogu u razvoju. Homolozi notch-liganda su također identifikovani kod ljudi, ali precizne interakcije između ovih liganada i ljudsjih homologa ostaju da se utvrde. Ovaj protein se cijepa u trans-Golgi mreži i edksprimira na površini ćelije kao heterodimer. Ovaj protein funkcionira kao receptor za ligande vezane za membranu i može imati ulogu u razvoju vaskularne mreže, bubrega i jetre.^[9]

Pokazalo se da su mutacije unutar posljednjeg kodirajućeg egzona Notch2 koje uklanjaju PEST domen i izbjegavaju nonsens posredovani raspad iRNK glavni uzrok Hajdu–Cheneyevog sindroma.^[10]^[11]^[12]

Interakcije

Pokazalo se da NOTCH2 ima interakcije sa:

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134250 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027878 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Larsson C, Lardelli M, White I, Lendahl U (maj 1995). "The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation". Genomics. 24 (2): 253–8. doi:10.1006/geno.1994.1613. PMID 7698746.
^ Samejima H, Torii C, Kosaki R, Kurosawa K, Yoshihashi H, Muroya K, Okamoto N, Watanabe Y, Kosho T, Kubota M, Matsuda O, Goto M, Izumi K, Takahashi T, Kosaki K (2007). "Screening for Alagille syndrome mutations in the JAG1 and NOTCH2 genes using denaturing high-performance liquid chromatography". Genet. Test. 11 (3): 216–27. doi:10.1089/gte.2006.0519. PMID 17949281.
^ Simpson MA, Irving MD, Asilmaz E, Gray MJ, Dafou D, Elmslie FV, Mansour S, Holder SE, Brain CE, Burton BK, Kim KH, Pauli RM, Aftimos S, Stewart H, Kim CA, Holder-Espinasse M, Robertson SP, Drake WM, Trembath RC (6. 3. 2011). "Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss". Nature Genetics. 43 (4): 303–5. doi:10.1038/ng.779. PMID 21378985. S2CID 205357391.
^ "UniProt, Q04721" (jezik: eng.). Pristupljeno 3. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ "Entrez Gene: NOTCH2 Notch homolog 2 (Drosophila)".
^ Simpson MA, Irving MD, Asilmaz E, Gray MJ, Dafou D, Elmslie FV, Mansour S, Holder SE, et al. (2011). "Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss". Nature Genetics. 43 (4): 303–305. doi:10.1038/ng.779. PMID 21378985. S2CID 205357391.
^ Isidor B, Lindenbaum P, Pichon O, Bézieau S, Dina C, Jacquemont S, Martin-Coignard D, Thauvin-Robinet C, Le Merrer M, Mandel JL, David A, Faivre L, Cormier-Daire V, Redon R, Le Caignec C (2011). "Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis". Nature Genetics. 43 (4): 306–8. doi:10.1038/ng.778. PMID 21378989. S2CID 205357384.
^ Majewski J, Schwartzentruber JA, Caqueret A, Patry L, Marcadier J, Fryns JP, Boycott KM, Ste-Marie LG, McKiernan FE, Marik I, Van Esch H, Michaud JL, Samuels ME (2011). "Mutations in NOTCH2 in families with Hajdu-Cheney syndrome". Hum Mutat. 32 (10): 1114–7. doi:10.1002/humu.21546. PMID 21681853. S2CID 39342783.
^ ^a ^b Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (juli 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. doi:10.1074/jbc.M103473200. PMID 11346656.
^ ^a ^b ^c Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (septembar 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/mcb.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
^ Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (juli 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. doi:10.1016/s0092-8674(00)80336-0. PMID 9244302. S2CID 16544864.
^ Espinosa L, Inglés-Esteve J, Aguilera C, Bigas A (august 2003). "Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways". J. Biol. Chem. 278 (34): 32227–35. doi:10.1074/jbc.M304001200. PMID 12794074.
^ Shimizu K, Chiba S, Kumano K, Hosoya N, Takahashi T, Kanda Y, Hamada Y, Yazaki Y, Hirai H (novembar 1999). "Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods". J. Biol. Chem. 274 (46): 32961–9. doi:10.1074/jbc.274.46.32961. PMID 10551863.

Dopunska literatura

Artavanis-Tsakonas S, Rand MD, Lake RJ (1999). "Notch signaling: cell fate control and signal integration in development". Science. 284 (5415): 770–6. Bibcode:1999Sci...284..770A. doi:10.1126/science.284.5415.770. PMID 10221902. S2CID 16790253.
Kojika S, Griffin JD (2001). "Notch receptors and hematopoiesis". Exp. Hematol. 29 (9): 1041–52. doi:10.1016/S0301-472X(01)00676-2. PMID 11532344.
Schwarzmeier JD, Hubmann R, Düchler M, Jäger U, Shehata M (2005). "Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemia". Leuk. Lymphoma. 46 (2): 157–65. doi:10.1080/10428190400010742. PMID 15621797. S2CID 36863790.
Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S (1993). "Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins". Nat. Genet. 2 (2): 119–27. doi:10.1038/ng1092-119. PMID 1303260. S2CID 32142845.
Katsanis N, Fitzgibbon J, Fisher EM (1996). "Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci". Genomics. 35 (1): 101–8. doi:10.1006/geno.1996.0328. PMID 8661110.
Hsieh JJ, Nofziger DE, Weinmaster G, Hayward SD (1997). "Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation". J. Virol. 71 (3): 1938–45. doi:10.1128/JVI.71.3.1938-1945.1997. PMC 191274. PMID 9032325.
Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. doi:10.1016/S0092-8674(00)80336-0. PMID 9244302. S2CID 16544864.
Bigas A, Martin DI, Milner LA (1998). "Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines". Mol. Cell. Biol. 18 (4): 2324–33. doi:10.1128/mcb.18.4.2324. PMC 121486. PMID 9528802.
Berezovska O, Xia MQ, Hyman BT (1998). "Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease". J. Neuropathol. Exp. Neurol. 57 (8): 738–45. doi:10.1097/00005072-199808000-00003. PMID 9720489.
Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999). "Human ligands of the Notch receptor". Am. J. Pathol. 154 (3): 785–94. doi:10.1016/S0002-9440(10)65325-4. PMC 1866435. PMID 10079256.
Shimizu K, Chiba S, Kumano K, Hosoya N, Takahashi T, Kanda Y, Hamada Y, Yazaki Y, Hirai H (2000). "Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods". J. Biol. Chem. 274 (46): 32961–9. doi:10.1074/jbc.274.46.32961. PMID 10551863.
Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (2001). "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors". Nat. Genet. 26 (4): 484–9. doi:10.1038/82644. PMID 11101851. S2CID 23335042.
Sriuranpong V, Borges MW, Ravi RK, Arnold DR, Nelkin BD, Baylin SB, Ball DW (2001). "Notch signaling induces cell cycle arrest in small cell lung cancer cells". Cancer Res. 61 (7): 3200–5. PMID 11306509.
Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. doi:10.1074/jbc.M103473200. PMID 11346656.
Saxena MT, Schroeter EH, Mumm JS, Kopan R (2001). "Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis". J. Biol. Chem. 276 (43): 40268–73. doi:10.1074/jbc.M107234200. PMID 11518718.
Inglés-Esteve J, Espinosa L, Milner LA, Caelles C, Bigas A (2002). "Phosphorylation of Ser2078 modulates the Notch2 function in 32D cell differentiation". J. Biol. Chem. 276 (48): 44873–80. doi:10.1074/jbc.M104703200. PMID 11577080.

Vanjski linkovi

Šablon:Notch signalni put

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134250 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027878 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7698746-5] Larsson C, Lardelli M, White I, Lendahl U (maj 1995). "The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation". Genomics. 24 (2): 253–8. doi:10.1006/geno.1994.1613. PMID 7698746.

[pmid17949281-6] Samejima H, Torii C, Kosaki R, Kurosawa K, Yoshihashi H, Muroya K, Okamoto N, Watanabe Y, Kosho T, Kubota M, Matsuda O, Goto M, Izumi K, Takahashi T, Kosaki K (2007). "Screening for Alagille syndrome mutations in the JAG1 and NOTCH2 genes using denaturing high-performance liquid chromatography". Genet. Test. 11 (3): 216–27. doi:10.1089/gte.2006.0519. PMID 17949281.

[pmid21378985-7] Simpson MA, Irving MD, Asilmaz E, Gray MJ, Dafou D, Elmslie FV, Mansour S, Holder SE, Brain CE, Burton BK, Kim KH, Pauli RM, Aftimos S, Stewart H, Kim CA, Holder-Espinasse M, Robertson SP, Drake WM, Trembath RC (6. 3. 2011). "Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss". Nature Genetics. 43 (4): 303–5. doi:10.1038/ng.779. PMID 21378985. S2CID 205357391.

[UniProt-8] "UniProt, Q04721" (jezik: eng.). Pristupljeno 3. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[entrez-9] "Entrez Gene: NOTCH2 Notch homolog 2 (Drosophila)".

[10] Simpson MA, Irving MD, Asilmaz E, Gray MJ, Dafou D, Elmslie FV, Mansour S, Holder SE, et al. (2011). "Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss". Nature Genetics. 43 (4): 303–305. doi:10.1038/ng.779. PMID 21378985. S2CID 205357391.

[11] Isidor B, Lindenbaum P, Pichon O, Bézieau S, Dina C, Jacquemont S, Martin-Coignard D, Thauvin-Robinet C, Le Merrer M, Mandel JL, David A, Faivre L, Cormier-Daire V, Redon R, Le Caignec C (2011). "Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis". Nature Genetics. 43 (4): 306–8. doi:10.1038/ng.778. PMID 21378989. S2CID 205357384.

[pmid21681853-12] Majewski J, Schwartzentruber JA, Caqueret A, Patry L, Marcadier J, Fryns JP, Boycott KM, Ste-Marie LG, McKiernan FE, Marik I, Van Esch H, Michaud JL, Samuels ME (2011). "Mutations in NOTCH2 in families with Hajdu-Cheney syndrome". Hum Mutat. 32 (10): 1114–7. doi:10.1002/humu.21546. PMID 21681853. S2CID 39342783.

[pmid11346656-13] Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (juli 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. doi:10.1074/jbc.M103473200. PMID 11346656.

[pmid10958687-14] Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (septembar 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/mcb.20.18.6913-6922.2000. PMC 88767. PMID 10958687.

[pmid9244302-15] Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (juli 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. doi:10.1016/s0092-8674(00)80336-0. PMID 9244302. S2CID 16544864.

[pmid12794074-16] Espinosa L, Inglés-Esteve J, Aguilera C, Bigas A (august 2003). "Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways". J. Biol. Chem. 278 (34): 32227–35. doi:10.1074/jbc.M304001200. PMID 12794074.

[pmid10551863-17] Shimizu K, Chiba S, Kumano K, Hosoya N, Takahashi T, Kanda Y, Hamada Y, Yazaki Y, Hirai H (novembar 1999). "Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods". J. Biol. Chem. 274 (46): 32961–9. doi:10.1074/jbc.274.46.32961. PMID 10551863.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]