OTUD7B

OTUD7B
Identifikatori
Aliasi	OTUD7B
Vanjski ID-jevi	OMIM: 611748 MGI: 2654703 HomoloGene: 10624 GeneCards: OTUD7B
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1q21.2 Početak 149,937,812 bp[1] Kraj 150,010,726 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3|3 F2.1 Početak 96,011,839 bp[2] Kraj 96,068,446 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje sa DNK • cysteine-type peptidase activity • vezivanje iona cinka • vezivanje iona metala • GO:0070122 peptidase activity • K63-linked polyubiquitin modification-dependent protein binding • GO:0001948, GO:0016582 vezivanje za proteine • thiol-dependent deubiquitinase • hydrolase activity • Lys48-specific deubiquitinase activity Ćelijska komponenta • citoplazma • jedro • citosol Biološki proces • mucosal immune response • negative regulation of protein localization to nucleus • protein K48-linked deubiquitination • protein deubiquitination involved in ubiquitin-dependent protein catabolic process • immune system process • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of I-kappaB kinase/NF-kappaB signaling • Proteoliza • negative regulation of interleukin-8 production • protein K63-linked deubiquitination • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • protein deubiquitination • protein K11-linked deubiquitination • adaptive immune response Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	56957	229603
Ensembl	ENSG00000264522	ENSMUSG00000038495
UniProt	Q6GQQ9	B2RUR8
RefSeq (mRNK)	NM_020205	NM_001025613 NM_001025614
RefSeq (bjelančevina)	NP_064590	NP_001020784 NP_001020785
Lokacija (UCSC)	Chr 1: 149.94 – 150.01 Mb	Chr 3: 96.01 – 96.07 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Protein 7B sa domenom OTU jest protein koji je kod ljudi kodiran genom OTUD7B sa hromosoma 1.^[5][6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 843 aminokiseline, a molekulska težina 92.526 Da.^[7]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MTLDMDAVLS		DFVRSTGAEP		GLARDLLEGK		NWDVNAALSD		FEQLRQVHAG
NLPPSFSEGS		GGSRTPEKGF		SDREPTRPPR		PILQRQDDIV		QEKRLSRGIS
HASSSIVSLA		RSHVSSNGGG		GGSNEHPLEM		PICAFQLPDL		TVYNEDFRSF
IERDLIEQSM		LVALEQAGRL		NWWVSVDPTS		QRLLPLATTG		DGNCLLHAAS
LGMWGFHDRD		LMLRKALYAL		MEKGVEKEAL		KRRWRWQQTQ		QNKESGLVYT
EDEWQKEWNE		LIKLASSEPR		MHLGTNGANC		GGVESSEEPV		YESLEEFHVF
VLAHVLRRPI		VVVADTMLRD		SGGEAFAPIP		FGGIYLPLEV		PASQCHRSPL
VLAYDQAHFS		ALVSMEQKEN		TKEQAVIPLT		DSEYKLLPLH		FAVDPGKGWE
WGKDDSDNVR		LASVILSLEV		KLHLLHSYMN		VKWIPLSSDA		QAPLAQPESP
TASAGDEPRS		TPESGDSDKE		SVGSSSTSNE		GGRRKEKSKR		DREKDKKRAD
SVANKLGSFG		KTLGSKLKKN		MGGLMHSKGS		KPGGVGTGLG		GSSGTETLEK
KKKNSLKSWK		GGKEEAAGDG		PVSEKPPAES		VGNGGSKYSQ		EVMQSLSILR
TAMQGEGKFI		FVGTLKMGHR		HQYQEEMIQR		YLSDAEERFL		AEQKQKEAER
KIMNGGIGGG		PPPAKKPEPD		AREEQPTGPP		AESRAMAFST		GYPGDFTIPR
PSGGGVHCQE		PRRQLAGGPC		VGGLPPYATF		PRQCPPGRPY		PHQDSIPSLE
PGSHSKDGLH		RGALLPPPYR		VADSYSNGYR		EPPEPDGWAG		GLRGLPPTQT
KCKQPNCSFY		GHPETNNFCS		CCYREELRRR		EREPDGELLV		HRF

Reference

1. GRCh38: Ensembl release 89: ENSG00000264522 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038495 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ (Jul 2001). "Isolation and characterization of two novel A20-like proteins". Journal of Biochemistry. 357 (Pt 3): 617–23. doi:10.1042/0264-6021:3570617. PMC 1221992. PMID 11463333.
6. "Entrez Gene: OTUD7B OTU domain containing 7B".
7. "UniProt, Q6GQQ9" (jezik: engleski). Pristupljeno 15. 12. 2021.

Dopunska literatura

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Evans PC, Ovaa H, Hamon M, et al. (2004). "Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity". Biochem. J. 378 (Pt 3): 727–34. doi:10.1042/BJ20031377. PMC 1224040. PMID 14748687.
• Evans PC, Smith TS, Lai MJ, et al. (2003). "A novel type of deubiquitinating enzyme". Journal of Biological Chemistry. 278 (25): 23180–6. doi:10.1074/jbc.M301863200. PMID 12682062.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Heyninck K, Beyaert R (1999). "The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Letters. 442 (2–3): 147–50. doi:10.1016/S0014-5793(98)01645-7. PMID 9928991.