RPL27A

RPL27A
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4BXF, 4UG0, 4V6X, 5AJ0, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifikatori
Aliasi	RPL27A
Vanjski ID-jevi	OMIM: 603637 MGI: 1347076 HomoloGene: 115477 GeneCards: RPL27A
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	8,714,759 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	109,121,574 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • structural constituent of ribosome; • vezivanje sa RNK;
Ćelijska komponenta	• intracellular anatomical structure; • ribozom; • large ribosomal subunit; • membrana; • cytosolic large ribosomal subunit; • Endoplazmatski retikulum; • citosol;
Biološki proces	• Nonsens-posredovano propadanje iRNK; • SRP-dependent cotranslational protein targeting to membrane; • viral transcription; • translational initiation; • Biosinteza bjelančevina; • rRNA processing; • cytoplasmic translation;
	Izvori:Amigo / QuickGO
Ortolozi
	6157
	26451
	ENSG00000166441
	ENSMUSG00000046364
	P46776
	P14115
	NM_032650; NM_000990
	NM_011975
	NP_000981
	NP_036105
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica 60S ribosomskog proteina L27a je protein koji je kod ljudi kodiran genom RPL27A.^[5]^[6]^[7]

Ribosomi, organele koje kataliziraju sintezu proteina, sastoje se od male 40S i velike 60S podjedinice. Ove podjedinice zajedno se sastoje od četiri tipa RNK i približno 80 strukturno različitih proteina. Ovaj gen kodira ribosomni protein koji je komponenta podjedinice 60S. Ovaj protein pripada porodici L15P ribosomnih proteina. Nalazi se u citoplazmi. Uočena je varijabilna ekspresija ovog gena u kolorekttumskom karcinomu u poređenju sa susjednim normalnim tkivima, iako nije pronađena korelacija između nivoa ekspresije i težine bolesti. Kao što je tipski za gene koji kodiraju ribosomske proteine, više obrađenih pseudogena izvedenih iz ovog gena raspršeno je širom genoma.^[7]

Aminokiaelinska sekvenca

Dužina polipeptidnog lanca je 148 aminokiselina, а molekulska težina 16.561 Da.^[8]

10	20	30	40	50
MPSRLRKTRK	LRGHVSHGHG	RIGKHRKHPG	GRGNAGGLHH	HRINFDKYHP
GYFGKVGMKH	YHLKRNQSFC	PTVNLDKLWT	LVSEQTRVNA	AKNKTGAAPI
IDVVRSGYYK	VLGKGKLPKQ	PVIVKAKFFS	RRAEEKIKSV	GGACVLVA

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166441 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046364 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID 7772601.
^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
^ ^a ^b "Entrez Gene: RPL27A ribosomal protein L27a".
^ "UniProt, P46776". Pristupljeno 26. 8. 2021.

Dopunska literatura

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–947. doi:10.1139/o95-101. PMID 8722009.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA (2002). "Differential expression of genes coding for ribosomal proteins in different human tissues". Bioinformatics. 17 (12): 1152–1157. doi:10.1093/bioinformatics/17.12.1152. PMID 11751223.
Kusuda J, Hirai M, Tanuma R, et al. (1999). "Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A". Cytogenet. Cell Genet. 85 (3–4): 248–251. doi:10.1159/000015303. PMID 10449908. S2CID 7314458.

Vanjski linkovi

Šablon:Ribosomne podjedinice

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166441 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046364 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7772601-5] Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID 7772601.

[pmid9582194-6] Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.

[entrez-7] "Entrez Gene: RPL27A ribosomal protein L27a".

[UniProt-8] "UniProt, P46776". Pristupljeno 26. 8. 2021.

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