SLC8B1

SLC8B1
Identifikatori
Aliasi	SLC8B1
Vanjski ID-jevi	OMIM: 609841 MGI: 2180781 HomoloGene: 41602 GeneCards: SLC8B1
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek)[1] Bend 12q24.13 Početak 113,298,759 bp[1] Kraj 113,359,493 bp[1]
Lokacija gena (miš) Hrom. Hromosom 5 (miš)[2] Bend 5|5 F Početak 120,649,233 bp[2] Kraj 120,672,089 bp[2]
Ontologija gena Molekularna funkcija • protein homodimerization activity • vezivanje identičnih proteina • antiporter activity • calcium:cation antiporter activity • calcium:sodium antiporter activity • calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential Ćelijska komponenta • integral component of membrane • membrana • ćelijska membrana • Krista • mitohondrija • integral component of mitochondrial membrane • Sarkolema • mitochondrial inner membrane Biološki proces • sodium ion transmembrane transport • regulation of cytosolic calcium ion concentration • glucose homeostasis • response to stimulus • regulation of insulin secretion • sodium ion transport • ion transport • calcium ion transmembrane transport • regulation of cardiac muscle cell membrane potential • calcium ion transport • transmembrane transport • mitochondrial calcium ion transmembrane transport • mitochondrial calcium ion homeostasis • calcium export from the mitochondrion • regulation of lymphocyte chemotaxis • regulation of store-operated calcium entry Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	80024	170756
Ensembl	ENSG00000089060	ENSMUSG00000032754
UniProt	Q6J4K2	Q925Q3
RefSeq (mRNK)	NM_024959 NM_001330466 NM_001358345	NM_001177594 NM_001177595 NM_133221
RefSeq (bjelančevina)	NP_001317395 NP_079235 NP_001345274	NP_001171065 NP_001171066 NP_573484
Lokacija (UCSC)	Chr 12: 113.3 – 113.36 Mb	Chr 5: 120.65 – 120.67 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Član B1 porodice rastvornih nosača 8 (natrij/litij/kalcijski izmjenjivač exchanger) je protein koji je kod ljudi kodiran genom SLC8B1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 584 aminokiselina, a molekulska težina 64.231 Da.^[6]

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin

I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MAGRRLNLRW		ALSVLCVLLM		AETVSGTRGS		STGAHISPQF		PASGVNQTPV
VDCRKVCGLN		VSDRCDFIRT		NPDCHSDGGY		LDYLEGIFCH		FPPSLLPLAV
TLYVSWLLYL		FLILGVTAAK		FFCPNLSAIS		TTLKLSHNVA		GVTFLAFGNG
APDIFSALVA		FSDPHTAGLA		LGALFGAGVL		VTTVVAGGIT		ILHPFMAASR
PFFRDIVFYM		VAVFLTFLML		FRGRVTLAWA		LGYLGLYVFY		VVTVILCTWI
YQRQRRGSLF		CPMPVTPEIL		SDSEEDRVSS		NTNSYDYGDE		YRPLFFYQET
TAQILVRALN		PLDYMKWRRK		SAYWKALKVF		KLPVEFLLLL		TVPVVDPDKD
DQNWKRPLNC		LHLVISPLVV		VLTLQSGTYG		VYEIGGLVPV		WVVVVIAGTA
LASVTFFATS		DSQPPRLHWL		FAFLGFLTSA		LWINAAATEV		VNILRSLGVV
FRLSNTVLGL		TLLAWGNSIG		DAFSDFTLAR		QGYPRMAFSA		CFGGIIFNIL
VGVGLGCLLQ		ISRSHTEVKL		EPDGLLVWVL		AGALGLSLVF		SLVSVPLQCF
QLSRVYGFCL		LLFYLNFLVV		ALLTEFGVIH		LKSM

Funkcija

SLC24A6 pripada porodici Kalij-ovisni izmjenjivač natrij-kalcij koji održavaju ćelijsku homeostazu kalcija, putem elektrogenog protivtransporta četiri iona natrija za jedan ion kalcija i jedan kalija.^[7]

Reference

1. GRCh38: Ensembl release 89: ENSG00000089060 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032754 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1".
6. "UniProt, Q6J4K2". Pristupljeno 14. 8. 2021.
7. Cai X, Lytton J (februar 2004). "Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6". The Journal of Biological Chemistry. 279 (7): 5867–76. doi:10.1074/jbc.M310908200. PMID 14625281.

Dopunska literatura

• Boyman L, Williams GS, Khananshvili D, Sekler I, Lederer WJ (juni 2013). "NCLX: the mitochondrial sodium calcium exchanger". Journal of Molecular and Cellular Cardiology. 59: 205–13. doi:10.1016/j.yjmcc.2013.03.012. PMC 3951392. PMID 23538132.
• Palty R, Ohana E, Hershfinkel M, Volokita M, Elgazar V, Beharier O, Silverman WF, Argaman M, Sekler I (juni 2004). "Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger". The Journal of Biological Chemistry. 279 (24): 25234–40. doi:10.1074/jbc.M401229200. PMID 15060069.
• Aslibekyan S, An P, Frazier-Wood AC, Kabagambe EK, Irvin MR, Straka RJ, Tiwari HK, Tsai MY, Hopkins PN, Borecki IB, Ordovas JM, Arnett DK (oktobar 2013). "Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network". Nutrition, Metabolism, and Cardiovascular Diseases. 23 (10): 987–94. doi:10.1016/j.numecd.2012.07.010. PMC 3578131. PMID 23149075.