SPRR1A

SPRR1A
Identifikatori
Aliasi	SPRR1A
Vanjski ID-jevi	OMIM: 182265 MGI: 106660 HomoloGene: 105698 GeneCards: SPRR1A
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1q21.3 Početak 152,984,081 bp[1] Kraj 152,985,814 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3 F1|3 40.14 cM Početak 92,391,259 bp[2] Kraj 92,393,202 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • protein-macromolecule adaptor activity • GO:0001948, GO:0016582 vezivanje za proteine • structural molecule activity • structural constituent of skin epidermis Ćelijska komponenta • citoplazma • cornified envelope • citosol Biološki proces • GO:0051357, GO:0051358, GO:0051359 peptide cross-linking • keratinization • keratinocyte differentiation • epidermis development • cornification Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6698	20753
Ensembl	ENSG00000169474	ENSMUSG00000050359
UniProt	P35321	Q62266
RefSeq (mRNK)	NM_005987 NM_001199828	NM_009264
RefSeq (bjelančevina)	NP_001186757 NP_005978	NP_033290
Lokacija (UCSC)	Chr 1: 152.98 – 152.99 Mb	Chr 3: 92.39 – 92.39 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Kornifin-A jest protein koji je kod ljudi kodiran genom SPRR1A sa hromosoma 1.^[5][6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 89 aminokiselina, a molekulska težina 9.877 Da.^[7]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MNSQQQKQPC		TPPPQPQQQQ		VKQPCQPPPQ		EPCIPKTKEP		CHPKVPEPCH
PKVPEPCQPK		VPEPCQPKVP		EPCPSTVTPA		PAQQKTKQK

Reference

1. GRCh38: Ensembl release 89: ENSG00000169474 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050359 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (juni 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.
6. "Entrez Gene: SPRR1A small proline-rich protein 1A".
7. "UniProt, P35321" (jezik: engleski). Pristupljeno 19. 12. 2021.

Dopunska literatura

• Greco MA, Lorand L, Lane WS, Baden HP, Parameswaran KN, Kvedar JC (februar 1995). "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation". The Journal of Investigative Dermatology. 104 (2): 204–10. doi:10.1111/1523-1747.ep12612759. PMID 7829876.
• Robinson PA, Marley JJ, High AS, Hume WJ (mart 1994). "Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts". Archives of Oral Biology. 39 (3): 251–9. doi:10.1016/0003-9969(94)90051-5. PMID 8018055.
• Fujimoto W, Nakanishi G, Arata J, Jetten AM (februar 1997). "Differential expression of human cornifin alpha and beta in squamous differentiating epithelial tissues and several skin lesions". The Journal of Investigative Dermatology. 108 (2): 200–4. doi:10.1111/1523-1747.ep12334240. PMID 9008234.
• Robinson NA, Lapic S, Welter JF, Eckert RL (maj 1997). "S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes". The Journal of Biological Chemistry. 272 (18): 12035–46. doi:10.1074/jbc.272.18.12035. PMID 9115270.
• Reddy SP, Konkin T, Wu R (decembar 1998). "Structure and organization of the genes encoding mouse small proline-rich proteins, mSPRR1A and 1B". Gene. 224 (1–2): 59–66. doi:10.1016/S0378-1119(98)00507-1. PMID 9931436.
• Candi E, Tarcsa E, Idler WW, Kartasova T, Marekov LN, Steinert PM (mart 1999). "Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin". The Journal of Biological Chemistry. 274 (11): 7226–37. doi:10.1074/jbc.274.11.7226. PMID 10066784.
• Lee CH, Marekov LN, Kim S, Brahim JS, Park MH, Steinert PM (juli 2000). "Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes". FEBS Letters. 477 (3): 268–72. doi:10.1016/S0014-5793(00)01806-8. PMID 10908733.
• Hartley JL, Temple GF, Brasch MA (novembar 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Cabral A, Voskamp P, Cleton-Jansen AM, South A, Nizetic D, Backendorf C (juni 2001). "Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function". The Journal of Biological Chemistry. 276 (22): 19231–7. doi:10.1074/jbc.M100336200. PMID 11279051.
• Bonilla IE, Tanabe K, Strittmatter SM (februar 2002). "Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth". The Journal of Neuroscience. 22 (4): 1303–15. doi:10.1523/JNEUROSCI.22-04-01303.2002. PMC 6757578. PMID 11850458.