SPSB1

SPSB1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2JK9, 3F2O
Identifikatori
Aliasi	SPSB1
Vanjski ID-jevi	OMIM: 611657 MGI: 1921896 HomoloGene: 11832 GeneCards: SPSB1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	9,369,532 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	150,039,500 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • GO:0050372 aktivnost sa transferazom ubikvitina; • ubiquitin ligase-substrate adaptor activity;
Ćelijska komponenta	• citoplazma; • citosol; • SCF ubiquitin ligase complex;
Biološki proces	• protein ubiquitination; • protein polyubiquitination; • Posttranslacione modifikacije; • ubiquitin-dependent protein catabolic process; • proteasome-mediated ubiquitin-dependent protein catabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	80176
	74646
	ENSG00000171621
	ENSMUSG00000039911
	Q96BD6
	Q9D5L7
	NM_025106
	NM_029035
	NP_079382
	NP_083311
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein SPRY sa domenim SOCS-kutije proteina 1 jest protein koji je kod ljudi kodiran genom SPSB1 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 273 aminokiseline, a molekulska težina 30.942 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGQKVTGGIK	TVDMRDPTYR	PLKQELQGLD	YCKPTRLDLL	LDMPPVSYDV
QLLHSWNNND	RSLNVFVKED	DKLIFHRHPV	AQSTDAIRGK	VGYTRGLHVW
QITWAMRQRG	THAVVGVATA	DAPLHSVGYT	TLVGNNHESW	GWDLGRNRLY
HDGKNQPSKT	YPAFLEPDET	FIVPDSFLVA	LDMDDGTLSF	IVDGQYMGVA
FRGLKGKKLY	PVVSAVWGHC	EIRMRYLNGL	DPEPLPLMDL	CRRSVRLALG
RERLGEIHTL	PLPASLKAYL	LYQ

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171621 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039911 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang D, Li Z, Messing EM, Wu G (Apr 2005). "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway". J Biol Chem. 280 (16): 16393–401. doi:10.1074/jbc.M413897200. PMID 15713673.
^ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
^ "Entrez Gene: SPSB1 splA/ryanodine receptor domain and SOCS box containing 1".
^ "UniProt, Q96BD6" (jezik: eng.). Pristupljeno 5. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC 1422157. PMID 16498413.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171621 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039911 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15713673-5] Wang D, Li Z, Messing EM, Wu G (Apr 2005). "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway". J Biol Chem. 280 (16): 16393–401. doi:10.1074/jbc.M413897200. PMID 15713673.

[pmid12076535-6] Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.

[entrez-7] "Entrez Gene: SPSB1 splA/ryanodine receptor domain and SOCS box containing 1".

[UniProt-8] "UniProt, Q96BD6" (jezik: eng.). Pristupljeno 5. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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