TNFSF12-TNFSF13

TNFSF12-TNFSF13
Dostupne strukture PDB Pretraga Human UniProta: PDBe RCSB Spisak PDB ID kodova 4HT1
Identifikatori
Aliasi	TNFSF12-TNFSF13
Vanjski ID-jevi	MGI: 3845075 HomoloGene: 123930 GeneCards: TNFSF12-TNFSF13
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek)[1] Bend 17p13.1 Početak 7,549,099 bp[1] Kraj 7,561,601 bp[1]
Lokacija gena (miš) Hrom. Hromosom 11 (miš)[2] Bend 11|11 B3 Početak 69,573,403 bp[2] Kraj 69,586,924 bp[2]
Ontologija gena Molekularna funkcija • cytokine activity • GO:0001948, GO:0016582 vezivanje za proteine • tumor necrosis factor receptor binding • signaling receptor binding Ćelijska komponenta • integral component of membrane • membrana • ćelijska membrana • integral component of plasma membrane • extracellular region • perinuklearno područje citoplazme • Vanćelijsko Biološki proces • Ćelijska diferencijacija • positive regulation of endothelial cell proliferation • GO:1903364 positive regulation of protein catabolic process • extrinsic apoptotic signaling pathway • tumor necrosis factor-mediated signaling pathway • positive regulation of angiogenesis • multicellular organism development • Angiogeneza • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • apoptotic signaling pathway • positive regulation of extrinsic apoptotic signaling pathway • endothelial cell migration • GO:0072468 Transdukcija signala • GO:0097285 apoptoza • regulation of signaling receptor activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	407977	619441
Ensembl	ENSG00000248871	ENSMUSG00000018752
UniProt	O43508	n/a
RefSeq (mRNK)	NM_172089	NM_001034097 NM_001034098 NM_001159503
RefSeq (bjelančevina)	NP_003800	n/a
Lokacija (UCSC)	Chr 17: 7.55 – 7.56 Mb	Chr 11: 69.57 – 69.59 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Superporodični faktor tumorske nekroze, ligandni članovi 12 i 13, znan i kao TNFSF12-TNFSF13, je ljudski gen.^[5]

Ovaj gen pripada superporodici faktora tumorskih nekroza (TNFSF). Kodira hibridni protein sastavljen od citoplazmatskog i transmembranskog domena člana porodice 12, koji je spojen sa C-terminalnim domenom člana porodice 13. Hibridni protein je membranski protein i predstavlja receptor-vezujući domen člana porodice 13 na ćelijskoj površini. Podstiče cikluse ćelijskih linija T-limfoma i B-limfoma. Transkript iRNK translatiran je i eksprimiran u primarnim T-ćelijama i monocitima.^[5]

Dužina polipeptidnog lanca je 249 aminokiselina, a molekulska težina 27.216.^[6]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MAARRSQRRR		GRRGEPGTAL		LVPLALGLGL		ALACLGLLLA		VVSLGSRASL
SAQEPAQEEL		VAEEDQDPSE		LNPQTEESQD		PAPFLNRLVR		PRRSAPKGRK
TRARRAIAAH		YEVHPRPGQD		GAQAGVDGTV		SGWEEARINS		SSPLRYNRQI
GEFIVTRAGL		YYLYCQVHFD		EGKAVYLKLD		LLVDGVLALR		CLEEFSATAA
SSLGPQLRLC		QVSGLLALRP		GSSLRIRTLP		WAHLKAAPFL		TYFGLFQVH

Reference

1. GRCh38: Ensembl release 89: ENSG00000248871 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018752 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TNFSF12-TNFSF13 tumor necrosis factor (ligand) superfamily, member 12-member 13".
6. "UniProt, O43508". Pristupljeno 12. 6. 2021.

Dopunska literatura

• Hahne M, Kataoka T, Schröter M, et al. (1998). "APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth". J. Exp. Med. 188 (6): 1185–90. doi:10.1084/jem.188.6.1185. PMC 2212534. PMID 9743536.
• Kelly K, Manos E, Jensen G, et al. (2000). "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death". Cancer Res. 60 (4): 1021–7. PMID 10706119.
• Wu Y, Bressette D, Carrell JA, et al. (2001). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". J. Biol. Chem. 275 (45): 35478–85. doi:10.1074/jbc.M005224200. PMID 10956646.
• Yu G, Boone T, Delaney J, et al. (2001). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity". Nat. Immunol. 1 (3): 252–6. doi:10.1038/79802. PMID 10973284. S2CID 6799584.
• López-Fraga M, Fernández R, Albar JP, Hahne M (2002). "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase". EMBO Rep. 2 (10): 945–51. doi:10.1093/embo-reports/kve198. PMC 1084076. PMID 11571266.
• Roschke V, Sosnovtseva S, Ward CD, et al. (2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". J. Immunol. 169 (8): 4314–21. doi:10.4049/jimmunol.169.8.4314. PMID 12370363.
• Pradet-Balade B, Medema JP, López-Fraga M, et al. (2002). "An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK–APRIL fusion protein". EMBO J. 21 (21): 5711–20. doi:10.1093/emboj/cdf565. PMC 131062. PMID 12411489.
• Hendriks J, Planelles L, de Jong-Odding J, et al. (2005). "Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation". Cell Death Differ. 12 (6): 637–48. doi:10.1038/sj.cdd.4401647. PMID 15846369.