UBR4

UBR4
Identifikatori
Aliasi	UBR4
Vanjski ID-jevi	OMIM: 609890 MGI: 1916366 HomoloGene: 10804 GeneCards: UBR4
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p36.13 Početak 19,074,510 bp[1] Kraj 19,210,266 bp[1]
Lokacija gena (miš) Hrom. Hromosom 4 (miš)[2] Bend 4|4 D3 Početak 139,079,920 bp[2] Kraj 139,216,899 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje iona cinka • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • calmodulin binding • GO:0050372 aktivnost sa transferazom ubikvitina • aktivnost sa transferazom Ćelijska komponenta • integral component of membrane • centrosom • citoskelet • membrana • jedro • nukleoplazma • citoplazma • citosol • ćelijska membrana • specific granule membrane • tertiary granule membrane • ficolin-1-rich granule membrane Biološki proces • GO:0022415 viral process • protein ubiquitination • neutrophil degranulation • ubiquitin-dependent protein catabolic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	23352	69116
Ensembl	ENSG00000127481	ENSMUSG00000066036
UniProt	Q5T4S7	A2AN08
RefSeq (mRNK)	NM_020765	NM_001160319
RefSeq (bjelančevina)	NP_065816	NP_001153791
Lokacija (UCSC)	Chr 1: 19.07 – 19.21 Mb	Chr 4: 139.08 – 139.22 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

E3 ubikvitin-protein ligaza UBR4 jest enzim koji je kod ljudi kodiran genom UBR4 sa hromosoma 1.^[5][6][7][8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 5.183 aminokiselina, a molekulska težina 573.841 Da.^[9]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MATSGGEEAA		AAAPAPGTPA		TGADTTPGWE		VAVRPLLSAS		YSAFEMKELP
QLVASVIESE		SEILHHEKQY		EPFYSSFVAL		STHYITTVCS		LIPRNQLQSV
AAACKVLIEF		SLLRLENPDE		ACAVSQKHLI		LLIKGLCTGC		SRLDRTEIIT
FTAMMKSAKL		PQTVKTLSDV		EDQKELASPV		SPELRQKEVQ		MNFLNQLTSV
FNPRTVASQP		ISTQTLVEGE		NDEQSSTDQA		SAIKTKNVFI		AQNVASLQEL
GGSEKLLRVC		LNLPYFLRYI		NRFQDAVLAN		SFFIMPATVA		DATAVRNGFH
SLVIDVTMAL		DTLSLPVLEP		LNPSRLQDVT		VLSLSCLYAG		VSVATCMAIL
HVGSAQQVRT		GSTSSKEDDY		ESDAATIVQK		CLEIYDMIGQ		AISSSRRAGG
EHYQNFQLLG		AWCLLNSLFL		ILNLSPTALA		DKGKEKDPLA		ALRVRDILSR
TKEGVGSPKL		GPGKGHQGFG		VLSVILANHA		IKLLTSLFQD		LQVEALHKGW
ETDGPPAALS		IMAQSTSIQR		IQRLIDSVPL		MNLLLTLLST		SYRKACVLQR
QRKGSMSSDA		SASTDSNTYY		EDDFSSTEED		SSQDDDSEPI		LGQWFEETIS
PSKEKAAPPP		PPPPPPLESS		PRVKSPSKQA		PGEKGNILAS		RKDPELFLGL
ASNILNFITS		SMLNSRNNFI		RNYLSVSLSE		HHMATLASII		KEVDKDGLKG
SSDEEFAAAL		YHFNHSLVTS		DLQSPNLQNT		LLQQLGVAPF		SEGPWPLYIH
PQSLSVLSRL		LLIWQHKASA		QGDPDVPECL		KVWDRFLSTM		KQNALQGVVP
SETEDLNVEH		LQMLLLIFHN		FTETGRRAIL		SLFVQIIQEL		SVNMDAQMRF
VPLILARLLL		IFDYLLHQYS		KAPVYLFEQV		QHNLLSPPFG		WASGSQDSNS
RRATTPLYHG		FKEVEENWSK		HFSSDAVPHP		RFYCVLSPEA		SEDDLNRLDS
VACDVLFSKL		VKYDELYAAL		TALLAAGSQL		DTVRRKENKN		VTALEACALQ
YYFLILWRIL		GILPPSKTYI		NQLSMNSPEM		SECDILHTLR		WSSRLRISSY
VNWIKDHLIK		QGMKAEHASS		LLELASTTKC		SSVKYDVEIV		EEYFARQISS
FCSIDCTTIL		QLHEIPSLQS		IYTLDAAISK		VQVSLDEHFS		KMAAETDPHK
SSEITKNLLP		ATLQLIDTYA		SFTRAYLLQN		FNEEGTTEKP		SKEKLQGFAA
VLAIGSSRCK		ANTLGPTLVQ		NLPSSVQTVC		ESWNNINTNE		FPNIGSWRNA
FANDTIPSES		YISAVQAAHL		GTLCSQSLPL		AASLKHTLLS		LVRLTGDLIV
WSDEMNPPQV		IRTLLPLLLE		SSTESVAEIS		SNSLERILGP		AESDEFLARV
YEKLITGCYN		ILANHADPNS		GLDESILEEC		LQYLEKQLES		SQARKAMEEF
FSDSGELVQI		MMATANENLS		AKFCNRVLKF		FTKLFQLTEK		SPNPSLLHLC
GSLAQLACVE		PVRLQAWLTR		MTTSPPKDSD		QLDVIQENRQ		LLQLLTTYIV
RENSQVGEGV		CAVLLGTLTP		MATEMLANGD		GTGFPELMVV		MATLASAGQG
AGHLQLHNAA		VDWLSRCKKY		LSQKNVVEKL		NANVMHGKHV		MILECTCHIM
SYLADVTNAL		SQSNGQGPSH		LSVDGEERAI		EVDSDWVEEL		AVEEEDSQAE
DSDEDSLCNK		LCTFTITQKE		FMNQHWYHCH		TCKMVDGVGV		CTVCAKVCHK
DHEISYAKYG		SFFCDCGAKE		DGSCLALVKR		TPSSGMSSTM		KESAFQSEPR
ISESLVRHAS		TSSPADKAKV		TISDGKVADE		EKPKKSSLCR		TVEGCREELQ
NQANFSFAPL		VLDMLNFLMD		AIQTNFQQAS		AVGSSSRAQQ		ALSELHTVEK
AVEMTDQLMV		PTLGSQEGAF		ENVRMNYSGD		QGQTIRQLIS		AHVLRRVAMC
VLSSPHGRRQ		HLAVSHEKGK		ITVLQLSALL		KQADSSKRKL		TLTRLASAPV
PFTVLSLTGN		PCKEDYLAVC		GLKDCHVLTF		SSSGSVSDHL		VLHPQLATGN
FIIKAVWLPG		SQTELAIVTA		DFVKIYDLCV		DALSPTFYFL		LPSSKIRDVT
FLFNEEGKNI		IVIMSSAGYI		YTQLMEEASS		AQQGPFYVTN		VLEINHEDLK
DSNSQVAGGG		VSVYYSHVLQ		MLFFSYCQGK		SFAATISRTT		LEVLQLFPIN
IKSSNGGSKT		SPALCQWSEV		MNHPGLVCCV		QQTTGVPLVV		MVKPDTFLIQ
EIKTLPAKAK		IQDMVAIRHT		ACNEQQRTTM		ILLCEDGSLR		IYMANVENTS
YWLQPSLQPS		SVISIMKPVR		KRKTATITTR		TSSQVTFPID		FFEHNQQLTD
VEFGGNDLLQ		VYNAQQIKHR		LNSTGMYVAN		TKPGGFTIEI		SNNNSTMVMT
GMRIQIGTQA		IERAPSYIEI		FGRTMQLNLS		RSRWFDFPFT		REEALQADKK
LNLFIGASVD		PAGVTMIDAV		KIYGKTKEQF		GWPDEPPEEF		PSASVSNICP
SNLNQSNGTG		DSDSAAPTTT		SGTVLERLVV		SSLEALESCF		AVGPIIEKER
NKNAAQELAT		LLLSLPAPAS		VQQQSKSLLA		SLHTSRSAYH		SHKDQALLSK
AVQCLNTSSK		EGKDLDPEVF		QRLVITARSI		AIMRPNNLVH		FTESKLPQME
TEGMDEGKEP		QKQLEGDCCS		FITQLVNHFW		KLHASKPKNA		FLAPACLPGL
THIEATVNAL		VDIIHGYCTC		ELDCINTASK		IYMQMLLCPD		PAVSFSCKQA
LIRVLRPRNK		RRHVTLPSSP		RSNTPMGDKD		DDDDDDADEK		MQSSGIPNGG
HIRQESQEQS		EVDHGDFEMV		SESMVLETAE		NVNNGNPSPL		EALLAGAEGF
PPMLDIPPDA		DDETMVELAI		ALSLQQDQQG		SSSSALGLQS		LGLSGQAPSS
SSLDAGTLSD		TTASAPASDD		EGSTAATDGS		TLRTSPADHG		GSVGSESGGS
AVDSVAGEHS		VSGRSSAYGD		ATAEGHPAGP		GSVSSSTGAI		STTTGHQEGD
GSEGEGEGET		EGDVHTSNRL		HMVRLMLLER		LLQTLPQLRN		VGGVRAIPYM
QVILMLTTDL		DGEDEKDKGA		LDNLLSQLIA		ELGMDKKDVS		KKNERSALNE
VHLVVMRLLS		VFMSRTKSGS		KSSICESSSL		ISSATAAALL		SSGAVDYCLH
VLKSLLEYWK		SQQNDEEPVA		TSQLLKPHTT		SSPPDMSPFF		LRQYVKGHAA
DVFEAYTQLL		TEMVLRLPYQ		IKKITDTNSR		IPPPVFDHSW		FYFLSEYLMI
QQTPFVRRQV		RKLLLFICGS		KEKYRQLRDL		HTLDSHVRGI		KKLLEEQGIF
LRASVVTASS		GSALQYDTLI		SLMEHLKACA		EIAAQRTINW		QKFCIKDDSV
LYFLLQVSFL		VDEGVSPVLL		QLLSCALCGS		KVLAALAASS		GSSSASSSSA
PVAASSGQAT		TQSKSSTKKS		KKEEKEKEKD		GETSGSQEDQ		LCTALVNQLN
KFADKETLIQ		FLRCFLLESN		SSSVRWQAHC		LTLHIYRNSS		KSQQELLLDL
MWSIWPELPA		YGRKAAQFVD		LLGYFSLKTP		QTEKKLKEYS		QKAVEILRTQ
NHILTNHPNS		NIYNTLSGLV		EFDGYYLESD		PCLVCNNPEV		PFCYIKLSSI
KVDTRYTTTQ		QVVKLIGSHT		ISKVTVKIGD		LKRTKMVRTI		NLYYNNRTVQ
AIVELKNKPA		RWHKAKKVQL		TPGQTEVKID		LPLPIVASNL		MIEFADFYEN
YQASTETLQC		PRCSASVPAN		PGVCGNCGEN		VYQCHKCRSI		NYDEKDPFLC
NACGFCKYAR		FDFMLYAKPC		CAVDPIENEE		DRKKAVSNIN		TLLDKADRVY
HQLMGHRPQL		ENLLCKVNEA		APEKPQDDSG		TAGGISSTSA		SVNRYILQLA
QEYCGDCKNS		FDELSKIIQK		VFASRKELLE		YDLQQREAAT		KSSRTSVQPT
FTASQYRALS		VLGCGHTSST		KCYGCASAVT		EHCITLLRAL		ATNPALRHIL
VSQGLIRELF		DYNLRRGAAA		MREEVRQLMC		LLTRDNPEAT		QQMNDLIIGK
VSTALKGHWA		NPDLASSLQY		EMLLLTDSIS		KEDSCWELRL		RCALSLFLMA
VNIKTPVVVE		NITLMCLRIL		QKLIKPPAPT		SKKNKDVPVE		ALTTVKPYCN
EIHAQAQLWL		KRDPKASYDA		WKKCLPIRGI		DGNGKAPSKS		ELRHLYLTEK
YVWRWKQFLS		RRGKRTSPLD		LKLGHNNWLR		QVLFTPATQA		ARQAACTIVE
ALATIPSRKQ		QVLDLLTSYL		DELSIAGECA		AEYLALYQKL		ITSAHWKVYL
AARGVLPYVG		NLITKEIARL		LALEEATLST		DLQQGYALKS		LTGLLSSFVE
VESIKRHFKS		RLVGTVLNGY		LCLRKLVVQR		TKLIDETQDM		LLEMLEDMTT
GTESETKAFM		AVCIETAKRY		NLDDYRTPVF		IFERLCSIIY		PEENEVTEFF
VTLEKDPQQE		DFLQGRMPGN		PYSSNEPGIG		PLMRDIKNKI		CQDCDLVALL
EDDSGMELLV		NNKIISLDLP		VAEVYKKVWC		TTNEGEPMRI		VYRMRGLLGD
ATEEFIESLD		STTDEEEDEE		EVYKMAGVMA		QCGGLECMLN		RLAGIRDFKQ
GRHLLTVLLK		LFSYCVKVKV		NRQQLVKLEM		NTLNVMLGTL		NLALVAEQES
KDSGGAAVAE		QVLSIMEIIL		DESNAEPLSE		DKGNLLLTGD		KDQLVMLLDQ
INSTFVRSNP		SVLQGLLRII		PYLSFGEVEK		MQILVERFKP		YCNFDKYDED
HSGDDKVFLD		CFCKIAAGIK		NNSNGHQLKD		LILQKGITQN		ALDYMKKHIP
SAKNLDADIW		KKFLSRPALP		FILRLLRGLA		IQHPGTQVLI		GTDSIPNLHK
LEQVSSDEGI		GTLAENLLEA		LREHPDVNKK		IDAARRETRA		EKKRMAMAMR
QKALGTLGMT		TNEKGQVVTK		TALLKQMEEL		IEEPGLTCCI		CREGYKFQPT
KVLGIYTFTK		RVALEEMENK		PRKQQGYSTV		SHFNIVHYDC		HLAAVRLARG
REEWESAALQ		NANTKCNGLL		PVWGPHVPES		AFATCLARHN		TYLQECTGQR
EPTYQLNIHD		IKLLFLRFAM		EQSFSADTGG		GGRESNIHLI		PYIIHTVLYV
LNTTRATSRE		EKNLQGFLEQ		PKEKWVESAF		EVDGPYYFTV		LALHILPPEQ
WRATRVEILR		RLLVTSQARA		VAPGGATRLT		DKAVKDYSAY		RSSLLFWALV
DLIYNMFKKV		PTSNTEGGWS		CSLAEYIRHN		DMPIYEAADK		ALKTFQEEFM
PVETFSEFLD		VAGLLSEITD		PESFLKDLLN		SVP

Reference

1. GRCh38: Ensembl release 89: ENSG00000127481 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066036 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S (Dec 2003). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
6. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
7. Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT (Aug 2005). "A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons". Mol Cell Biol. 25 (16): 7120–7136. doi:10.1128/MCB.25.16.7120-7136.2005. PMC 1190250. PMID 16055722.
8. "Entrez Gene: ZUBR1 zinc finger, UBR1 type 1".
9. "UniProt, Q5T4S7" (jezik: eng.). Pristupljeno 1. 12. 2021.

Dopunska literatura

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• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–349. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Huh KW, DeMasi J, Ogawa H, et al. (2005). "Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600". Proc. Natl. Acad. Sci. U.S.A. 102 (32): 11492–11497. Bibcode:2005PNAS..10211492H. doi:10.1073/pnas.0505337102. PMC 1182135. PMID 16061792.
• Nakatani Y, Konishi H, Vassilev A, et al. (2005). "p600, a unique protein required for membrane morphogenesis and cell survival". Proc. Natl. Acad. Sci. U.S.A. 102 (42): 15093–15098. doi:10.1073/pnas.0507458102. PMC 1247991. PMID 16214886.
• Lennerz V, Fatho M, Gentilini C, et al. (2005). "The response of autologous T cells to a human melanoma is dominated by mutated neoantigens". Proc. Natl. Acad. Sci. U.S.A. 102 (44): 16013–16018. Bibcode:2005PNAS..10216013L. doi:10.1073/pnas.0500090102. PMC 1266037. PMID 16247014.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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