HDAC1

HDAC1
Estructures disponibles PDB Cerca ortòloga: PDBe RCSB Llista de codis id de PDB 4BKX, 5ICN
Identificadors
Àlies	HDAC1 (HUGO), GON-10, HD1, RPD3, RPD3L1, histone deacetylase 1, KDAC1
Identif. externs	OMIM: 601241   MGI: 108086   HomoloGene: 68426   GeneCards: HDAC1   OMA: HDAC1 - orthologs
Dirigit pel fàrmac
abexinostat , apicidin , belinostat , àcid butíric, entinostat , givinostat , mocetinostat , panobinostat , pracinostat , quisinostat , resminostat , romidepsin , trichostatin A , àcid valproic, vorinostat , entinostat , cudc-101 , cudc-907 , tacedinaline  [1]
Localització del gen (humà) Cromosoma: 1 (humà)[2] Banda 1p35.2-p35.1 Inici 32.292.083 bp[2] Fi 32.333.635 bp[2]
Localització del gen (ratolí) Cromosoma: 4 (ratolí)[3] Banda 4 D2.2|4 63.26 cM Inici 129.409.897 bp[3] Fi 129.436.506 bp[3]
Patró d'expressió d'ARN Bgee humà ratolí (ortòleg) Més explicacions mucosa of colon  mucosa of sigmoid colon  mucosa of transverse colon  epithelium of nasopharynx  recte gangli limfàtic pílor right uterine tube  cec geniva Més explicacions tail of embryo  genital tubercle  mòrula ventricular zone  medul·la òssia sac vitel·lí tim embrió blastocist placenta Més referències a dades d'expressió BioGPS Més referències a dades d'expressió
Ontologia genètica Funció molecular RNA polymerase II cis-regulatory region sequence-specific DNA binding  NAD-dependent histone deacetylase activity (H3-K14 specific)  transcription corepressor activity  histone deacetylase activity  protein N-terminus binding  DNA-binding transcription factor activity  protein deacetylase activity  histone deacetylase binding  transcription cis-regulatory region binding  NF-kappaB binding  deacetylase activity  unió proteica  nucleosomal DNA binding  enzyme binding  activitat hidrolasa  core promoter sequence-specific DNA binding  p53 binding  transcription factor binding  RNA polymerase II core promoter sequence-specific DNA binding  DNA binding  chromatin binding  Krueppel-associated box domain binding  E-box binding  promoter-specific chromatin binding  Component cel·lular citoplasma  NuRD complex  citosol  histone deacetylase complex  Sin3 complex  nucleoplasma  nucli cel·lular  cromatina  Heterocromatina  transcription regulator complex  transcription repressor complex  complex macromolecular  cos cel·lular neuronal  Sin3-type complex  Procés biològic hair follicle placode formation  epidermal cell differentiation  chromatin remodeling  regulació de la transcripció, modelat amb ADN  procés rítmic  negative regulation of androgen receptor signaling pathway  embryonic digit morphogenesis  negative regulation of apoptotic process  coagulació de la sang  negative regulation of transcription by RNA polymerase II  eyelid development in camera-type eye  circadian regulation of gene expression  negative regulation of gene expression  positive regulation of transcription, DNA-templated  odontogenesis of dentin-containing tooth  protein deacetylation  histone H4 deacetylation  fungiform papilla formation  negative regulation of myotube differentiation  procés viral  histone deacetylation  negative regulation of canonical Wnt signaling pathway  positive regulation of transcription by RNA polymerase II  transcripció, plantilla d'ADN  regulation of signal transduction by p53 class mediator  DNA methylation-dependent heterochromatin assembly  beta-catenin-TCF complex assembly  chromatin organization  positive regulation of cell population proliferation  negative regulation of transcription, DNA-templated  histone H3 deacetylation  regulation of megakaryocyte differentiation  regulation of transcription by RNA polymerase II  endoderm development  ritme circadiari  hippocampus development  neuron differentiation  negative regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of oligodendrocyte differentiation  regulation of endopeptidase activity  regulation of amyloid-beta clearance  negative regulation of intrinsic apoptotic signaling pathway  Fonts: Amigo / QuickGO
Ortòlegs Espècies Humà Ratolí Entrez 3065 433759 Ensembl ENSG00000116478 ENSMUSG00000028800 UniProt Q13547 O09106 RefSeq (ARNm) NM_004964 NM_008228 RefSeq (proteïna) NP_004955 NP_032254 Localització (UCSC) Chr 1: 32.29 – 32.33 Mb Chr 4: 129.41 – 129.44 Mb Cerca a PubMed [4] [5]
Wikidata
Veure/Editar gen humà Veure/Editar gen del ratolí

La histona deacetilasa 1 (HDAC1) és un enzim codificat en humans pel gen HDAC1.^[6]

Funció

Les histones tenen un paper crucial en la regulació de la transcripció, en la progressió del cicle cel·lular i en processos de desenvolupament. La acetilació/desacetilació d'histones altera l'estructura del cromosoma, variant així l'accessibilitat dels factors de transcripció a l'ADN. La HDAC1 pertany a la família d'histona deacetilases acuc/alfa i és un dels components del complex histona deacetilasa. Aquesta proteïna interacciona amb la proteïna del retinoblastoma formant un complex que constitueix un element clau en el control de la proliferació cel·lular i la diferenciació cel·lular. Juntament amb la proteïna 2 associada a metàstasi, deacetila a p53 i modula la seva acció sobre la proliferació cel·lular i l'apoptosi.^[7]

Interaccions

La histona deacetilasa 1 ha demostrat ser capaç d'interaccionar amb:

• RAD9A^[8]
• DNMT3L^[9][10]
• MTA1^[11][12]
• FKBP3^[13]
• CDC20^[14]
• CDH1^[14]
• HCFC1^[15]
• BUB3^[14]
• NCOR2^[16][17]
• IKZF1^[18][19]
• Prohibitina^[20][21]
• EVI1^[22][23]
• DDX5^[24]
• DNMT3A^[25]
• SMAD2^[26]
• HDAC2^{[27][11][28][29][30][31][16][32][33][34][35][36][37]}
• MIER1^[38]
• SIN3A^{[39][11][40][41][42][43][44][33][45][34][35][46][47][48]}
• Proteína 6 associada a mort^[49]
• Receptor androgènic^[50]
• HMG20B^[27]
• HUS1^[8]
• IFRD1^[51]
• MLL^[52]
• ING1^[53][48]
• MyoD^[54][55]
• GATA1^[56]
• SPEN^[57]
• MAD1L1^[14]
• Proteïna de la leucèmia promielocítica^[58][59]
• CHD3^[34][48]
• TGIF1^[60][61]
• Proteïna del retinoblastoma-like 2^[62][63]
• Proteïna del retinoblastoma-like 1^[64][62]
• CHD4^[11][42][34]
• RCOR1^[27][44]
• RBBP7^{[11][65][33][36]}
• RFC1^[66]
• Proteïna del retinoblastoma^{[67][68][54][21][69][64][62]}
• RBBP4^{[39][11][70][42][44][71][65][33][45][35][36]}
• EED^[37]
• PHF21A^[27][72]
• SIN3B^[33][18]
• RELA^[73][74][32]
• NFKB1^[74]
• BUB1B^[14]
• Mdm2^[75]
• SATB1^[46]
• HSPA4^[30]
• SUV39H1^[76]
• BUB1^[14]
• MBD2^[77][65][33]
• ZBTB16^[78][79][80]
• DDX17^[24]
• BCL6^[79][81]
• SUDS3^[40][82]
• SAP30^{[83][84][33][85][86][48]}
• Sp1^{[87][88][45][89]}
• MTA2^{[11][44][33][46]}
• PCNA^[90]
• CBFA2T3^[91][92]
• TOP2B^[93][94]
• MBD3^[95][33][96]
• CTBP1^[97][60][98]
• TOP2A^[93][94]
• EZH2^[37]
• COUP-TFII^[99]

Referències

1. «Fàrmacs amb els quals interactuen físicament amb histone deacetylase 1, vegeu/editeu les referències a wikidata».
2. GRCh38: Ensembl release 89: ENSG00000116478 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000028800 – Ensembl, May 2017
4. «Human PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.
5. «Mouse PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.
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Enllaços externs

• «HDAC1» (en anglès). Medical Subject Headings.