JNJ 7777120

JNJ 7777120
(IUPAC) ime
	5-hloro-2-[(4-metilpiperazin-1-il)karbonil]-1H-indol
Klinički podaci
Identifikatori
CAS broj	459168-41-3
ATC kod	nije dodeljen
PubChem	4908365
ChEMBL	CHEMBL129198
Hemijski podaci
Formula	C14H16ClN3O
Mol. masa	277,749 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3 ; Key: HUQJRYMLJBBEDO-UHFFFAOYSA-N
Sinonimi	1-[(5-hloro-1H-indol-2-il)karbonil]-4-metilpiperazin
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

JNJ-7777120 je lek koji je razvila kompanija Džonson & Džonson. On deluje kao potentan i selektivan antagonist histaminskog H4 receptora.^[4] On ima antiinflamatorno dejstvo.^[5] Pokazano je da je superioran u odnosu na traditionalne antihistamine u treatmanu pruritusa (svraba).^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Jiang W, Lim HD, Zhang M, et al. (July 2008). „Cloning and pharmacological characterization of the dog histamine H(4) receptor”. Eur. J. Pharmacol. 592 (1–3): 26–32. DOI:10.1016/j.ejphar.2008.06.095. PMID 18639542.
↑ Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. Journal of Pharmacology and Experimental Therapeutics. 2004 Apr;309(1):404-13. PMID 14722321
↑ Dunford PJ, Williams KN, Desai PJ, Karlsson L, McQueen D, Thurmond RL. Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. Journal of Allergy and Clinical Immunology. 2007 Jan;119(1):176-83. PMID 17208599

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid18639542-4] Jiang W, Lim HD, Zhang M, et al. (July 2008). „Cloning and pharmacological characterization of the dog histamine H(4) receptor”. Eur. J. Pharmacol. 592 (1–3): 26–32. DOI:10.1016/j.ejphar.2008.06.095. PMID 18639542.

[5] Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. Journal of Pharmacology and Experimental Therapeutics. 2004 Apr;309(1):404-13. PMID 14722321

[6] Dunford PJ, Williams KN, Desai PJ, Karlsson L, McQueen D, Thurmond RL. Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. Journal of Allergy and Clinical Immunology. 2007 Jan;119(1):176-83. PMID 17208599

[1]

[2]

[3]

[4]

[5]

[6]