CCL5, hemokin (C-C motiv) ligand 5, takođe poznat kao RANTES (engl.Regulated upon Activation, Normal T-cell Expressed, and Secreted) je protein koji je kod ljudi kodiran CCL5genom.[1][2]
RANTES je prvobitno bio identifikovan u toku potrage za "kasno" izraženim genima (3–5 dana) nakon T ćelijske aktivacije. Naknadno je bilo utvrđeno da je on CC hemokin i da je izražen u više od 100 ljudskih bolesti. RANTES izražavanje je regulisano u T limfocitima Krupel sličnim faktorom 13 (KLF13).[5][6][7][8]
^Donlon TA, Krensky AM, Wallace MR, Collins FS, Lovett M, Clayberger C (1990). „Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12”. Genomics. 6 (3): 548—53. PMID1691736. doi:10.1016/0888-7543(90)90485-D.
^Maghazachi; et al. (1996). „CC chemokines induce the generation of killer cells from CD56+ cells”. Eur J Immunol. 26: 315—9. PMID8617297.
^Donlon; et al. (1990). „Localization of a human T-cell-specific gene, CCL5 (D17S136E), to chromosome 17q11.2-q12.”. Genomics. 5: 548—553. PMID1691736.
^Krensky, Alan M. (1995). Biology of the Chemokine in Rantes (Molecular Biology Intelligence Unit). R G Landes Co. ISBN978-1-57059-253-9.
^Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (1999). „RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes”. Immunity. 10 (1): 93—103. PMID10023774. doi:10.1016/S1074-7613(00)80010-2.
^ абвStruyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (2001). „Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils”. Eur. J. Immunol. 31 (7): 2170—8. PMID11449371. doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D.
^Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L (2003). „Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages”. Biochim. Biophys. Acta. 1617 (1-2): 80—8. PMID14637022.
^ абProudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN (2001). „The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity”. J. Biol. Chem. 276 (14): 10620—6. PMID11116158. doi:10.1074/jbc.M010867200.
Zhao RY, Bukrinsky M, Elder RT (2005). „HIV-1 viral protein R (Vpr) & host cellular responses.”. Indian J. Med. Res. 121 (4): 270—86. PMID15817944.
Li L; Li HS; Pauza CD; et al. (2006). „Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.”. Cell Res. 15 (11-12): 923—34. PMID16354571. doi:10.1038/sj.cr.7290370.
Krensky, Alan M. (1995). Biology of the Chemokine in Rantes (Molecular Biology Intelligence Unit). R G Landes Co.