CRTC2

CRTC2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4HTM
Identifikatori
Aliasi	CRTC2
Vanjski ID-jevi	OMIM: 608972 MGI: 1921593 HomoloGene: 18765 GeneCards: CRTC2
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1q21.3 Početak 153,947,669 bp[1] Kraj 153,958,615 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3|3 F1 Početak 90,161,470 bp[2] Kraj 90,171,432 bp[2]
Ontologija gena Molekularna funkcija • chromatin binding • GO:0001948, GO:0016582 vezivanje za proteine • cAMP response element binding protein binding Ćelijska komponenta • citoplazma • Egzosom • jedro • nukleoplazma Biološki proces • Glukoneogeneza • histone H3-K9 acetylation • positive regulation of CREB transcription factor activity • GO:0022415 viral process • GO:0009373 regulation of transcription, DNA-templated • protein homotetramerization • toxin transport • glucose homeostasis • transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	200186	74343
Ensembl	ENSG00000160741	ENSMUSG00000027936
UniProt	Q53ET0	Q3U182
RefSeq (mRNK)	NM_181715	NM_028881 NM_001357152
RefSeq (bjelančevina)	NP_859066	NP_083157 NP_001344081
Lokacija (UCSC)	Chr 1: 153.95 – 153.96 Mb	Chr 3: 90.16 – 90.17 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

CREB-regulirani transkripcijski koaktivator 2, znan i kao CRTC2, jest protein koji je kod ljudi kodiran genom CRTC2 sa hromosoma 1.^[5][6][7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 693 aminokiseline, a molekulska težina 73.302 Da.^[8]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MATSGANGPG		SATASASNPR		KFSEKIALQK		QRQAEETAAF		EEVMMDIGST
RLQAQKLRLA		YTRSSHYGGS		LPNVNQIGSG		LAEFQSPLHS		PLDSSRSTRH
HGLVERVQRD		PRRMVSPLRR		YTRHIDSSPY		SPAYLSPPPE		SSWRRTMAWG
NFPAEKGQLF		RLPSALNRTS		SDSALHTSVM		NPSPQDTYPG		PTPPSILPSR
RGGILDGEMD		PKVPAIEENL		LDDKHLLKPW		DAKKLSSSSS		RPRSCEVPGI
NIFPSPDQPA		NVPVLPPAMN		TGGSLPDLTN		LHFPPPLPTP		LDPEETAYPS
LSGGNSTSNL		THTMTHLGIS		RGMGLGPGYD		APGLHSPLSH		PSLQSSLSNP
NLQASLSSPQ		PQLQGSHSHP		SLPASSLARH		VLPTTSLGHP		SLSAPALSSS
SSSSSTSSPV		LGAPSYPAST		PGASPHHRRV		PLSPLSLLAG		PADARRSQQQ
LPKQFSPTMS		PTLSSITQGV		PLDTSKLSTD		QRLPPYPYSS		PSLVLPTQPH
TPKSLQQPGL		PSQSCSVQSS		GGQPPGRQSH		YGTPYPPGPS		GHGQQSYHRP
MSDFNLGNLE		QFSMESPSAS		LVLDPPGFSE		GPGFLGGEGP		MGGPQDPHTF
NHQNLTHCSR		HGSGPNIILT		GDSSPGFSKE		IAAALAGVPG		FEVSAAGLEL
GLGLEDELRM		EPLGLEGLNM		LSDPCALLPD		PAVEESFRSD		RLQ

Funkcija

CRTC2, prvobitno zvani TORC2, je transkripcijski koaktivator za faktor transkripcije CREB i centralni regulator glukoneogene ekspresije gena, kao odgovora na cAMP.^[9] Smatra se da CRTC2 pokreće tumorigenezu kod LKB11/STK11-null karcinoma nemalih ćelija pluća (NSCLC).^[10]

Interakcije

Pokazalo se da CRTC2 ima interakcije sa SNF1LK2^[11] i YWHAQ.^[11][12]

Reference

1. GRCh38: Ensembl release 89: ENSG00000160741 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027936 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2".
6. Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (oktobar 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
7. Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (august 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
8. "UniProt, Q53ET0" (jezik: en.). Pristupljeno 9. 12. 2021.
9. Cheng A, Saltiel AR (mart 2006). "More TORC for the gluconeogenic engine". BioEssays. 28 (3): 231–4. CiteSeerX 10.1.1.604.5745. doi:10.1002/bies.20375. PMID 16479585.
10. Rodón L, Svensson RU, Wiater E, Chun MG, Tsai WW, Eichner LJ, et al. (juli 2019). "The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer". Science Advances. 5 (7): eaaw6455. doi:10.1126/sciadv.aaw6455. PMC 6656544. PMID 31355336.
11. Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (oktobar 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.
12. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Dopunska literatura

• Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (oktobar 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
• Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (august 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, et al. (august 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (oktobar 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.
• Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, et al. (decembar 2005). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". Journal of Cell Science. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID 16306228.
• Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY (juli 2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats". Journal of Virology. 80 (14): 7052–9. doi:10.1128/JVI.00103-06. PMC 1489057. PMID 16809310.
• Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, et al. (septembar 2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells". Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14379–84. Bibcode:2006PNAS..10314379W. doi:10.1073/pnas.0606714103. PMC 1569674. PMID 16980408.
• Yang Q, Inoki K, Ikenoue T, Guan KL (oktobar 2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes & Development. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMC 1619946. PMID 17043309.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M (juni 2007). "Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression". The EMBO Journal. 26 (12): 2880–9. doi:10.1038/sj.emboj.7601715. PMC 1894761. PMID 17476304.
• Kuraishy AI, French SW, Sherman M, Herling M, Jones D, Wall R, Teitell MA (juni 2007). "TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation". Proceedings of the National Academy of Sciences of the United States of America. 104 (24): 10175–80. Bibcode:2007PNAS..10410175K. doi:10.1073/pnas.0704170104. PMC 1891214. PMID 17548807.

Vanjski linkovi

• CRTC2 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)
• Lokacija ljudskog genoma CRTC2 i stranica sa detaljima o genu CRTC2 u UCSC Genome Browseru.
• Q53ET0
• Q3U182