HDAC1

HDAC1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4BKX, 5ICN
Identifikatori
Aliasi	HDAC1
Vanjski ID-jevi	OMIM: 601241 MGI: 108086 HomoloGene: 68426 GeneCards: HDAC1
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p35.2-p35.1 Početak 32,292,083 bp[1] Kraj 32,333,635 bp[1]
Lokacija gena (miš) Hrom. Hromosom 4 (miš)[2] Bend 4 D2.2|4 63.26 cM Početak 129,409,897 bp[2] Kraj 129,436,506 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • GO:0001106 transcription corepressor activity • histone deacetylase activity • protein N-terminus binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • protein deacetylase activity • histone deacetylase binding • GO:0000975 transcription cis-regulatory region binding • NF-kappaB binding • deacetylase activity • GO:0001948, GO:0016582 vezivanje za proteine • nucleosomal DNA binding • vezivanje enzima • hydrolase activity • core promoter sequence-specific DNA binding • p53 binding • transcription factor binding • RNA polymerase II core promoter sequence-specific DNA binding • vezivanje sa DNK • chromatin binding • Krueppel-associated box domain binding • E-box binding • promoter-specific chromatin binding Ćelijska komponenta • citoplazma • NuRD complex • citosol • histone deacetylase complex • Sin3 complex • nukleoplazma • jedro • Hromatin • GO:0035328 heterochromatin • transcription regulator complex • transcription repressor complex • GO:0009327 makromolekulani kompleks • soma • Sin3-type complex Biološki proces • hair follicle placode formation • epidermal cell differentiation • chromatin remodeling • GO:0009373 regulation of transcription, DNA-templated • rhythmic process • negative regulation of androgen receptor signaling pathway • embryonic digit morphogenesis • negative regulation of apoptotic process • Koagulacija (krv) • GO:1901227 negative regulation of transcription by RNA polymerase II • eyelid development in camera-type eye • circadian regulation of gene expression • negative regulation of gene expression • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • odontogenesis of dentin-containing tooth • protein deacetylation • histone H4 deacetylation • fungiform papilla formation • negative regulation of myotube differentiation • GO:0022415 viral process • histone deacetylation • negative regulation of canonical Wnt signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription, DNA-templated • regulation of signal transduction by p53 class mediator • DNA methylation-dependent heterochromatin assembly • beta-catenin-TCF complex assembly • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • positive regulation of cell population proliferation • GO:0045996 negative regulation of transcription, DNA-templated • histone H3 deacetylation • regulation of megakaryocyte differentiation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • endoderm development • Jednodnevni biološki ritam • hippocampus development • neuron differentiation • negative regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of oligodendrocyte differentiation • regulation of endopeptidase activity • regulation of amyloid-beta clearance • negative regulation of intrinsic apoptotic signaling pathway Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3065	433759
Ensembl	ENSG00000116478	ENSMUSG00000028800
UniProt	Q13547	O09106
RefSeq (mRNK)	NM_004964	NM_008228
RefSeq (bjelančevina)	NP_004955	NP_032254
Lokacija (UCSC)	Chr 1: 32.29 – 32.33 Mb	Chr 4: 129.41 – 129.44 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Histon-deacetilaza 1 (HDAC1) jest enzim koji je kod ljudi kodiran genom HDAC1 sa hromosoma 1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 482 aminokiseline, a molekulska težina Da. 55.103^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAQTQGTRRK		VCYYYDGDVG		NYYYGQGHPM		KPHRIRMTHN		LLLNYGLYRK
MEIYRPHKAN		AEEMTKYHSD		DYIKFLRSIR		PDNMSEYSKQ		MQRFNVGEDC
PVFDGLFEFC		QLSTGGSVAS		AVKLNKQQTD		IAVNWAGGLH		HAKKSEASGF
CYVNDIVLAI		LELLKYHQRV		LYIDIDIHHG		DGVEEAFYTT		DRVMTVSFHK
YGEYFPGTGD		LRDIGAGKGK		YYAVNYPLRD		GIDDESYEAI		FKPVMSKVME
MFQPSAVVLQ		CGSDSLSGDR		LGCFNLTIKG		HAKCVEFVKS		FNLPMLMLGG
GGYTIRNVAR		CWTYETAVAL		DTEIPNELPY		NDYFEYFGPD		FKLHISPSNM
TNQNTNEYLE		KIKQRLFENL		RMLPHAPGVQ		MQAIPEDAIP		EESGDEDEDD
PDKRISICSS		DKRIACEEEF		SDSEEEGEGG		RKNSSNFKKA		KRVKTEDEKE
KDPEEKKEVT		EEEKTKEEKP		EAKGVKEEVK		LA

4

Funkcija

Acetilacija i deacetilacija histona, katalizirana kompleksima više podjedinica, ima ključnu ulogu u regulaciji eukariotske ekspresije gena. Protein kodiran ovim genom pripada porodici histon deacetilaza/acuc/alfa i komponenta je kompleksa histon-deacetilaza. Također je u interakciji sa proteinom supresorom tumora retinoblastoma i ovaj kompleks je ključni element u kontroli proliferacije i diferencijacije ćelija. Zajedno s proteinom-2 MTA2 povezanim s metastazama, deacetilira p53 i modulira njegov učinak na rast i ćelijsku apoptozu.^[7]

Modelni organizmi

Fenotip Hdac1 nokaut-miševa

Svojstvo	Fenotip
Vijabilnost homozigot	Nenormalan
Studija recesivne letalnosti	Nenormalan
Plodnost	Normalan
Tjelesna težina	Normalan
Anksioznost otvorenog polja	Normalan
Neurološka procjena	Normalan
Snaga stiska	Normalan
Test vruće ploče	Normalan
Dismorfologija	Normalan
Indirektna kalorimetrija	Normalan
Test tolerancije glukoze	Normalan
Slušni odgovor moždanog stabla	Normalan
DEXA	Normalan
Radiografija	Normalan
Tjelesna temperatura	Normalan
Morfologija oka	Normalan
Klinička hemija	Normalan
Hematologija	Normalan
Limfociti periferne krvi	Normalan
Mikronukleus test	Normalan
Težina srca	Normalan
Histopatologija mozga	Normalan
Histopatologija oka	Normalan
Salmonella infekcija	Normalan[8]
Citrobacter infekcija	Normalan[9]
Svi testovi i analize prema[10][11]

U proučavanju funkcije HDAC1 korišteni su modelni organizmi. Uvjetna linija nokaut-miševa, zvana Hdac1^{tm1a(EUCOMM)Wtsi[12][13]} gwnwrirana je kao dio programa Međunarodnog konzorcija za nokaut-miševe — visokoprolpusnog projekta mutageneze za generiranje i distribuciju modela životzinjskih bolesti zainteresiranim naučnicima — na Institutu Wellcome Trust Sanger.^[14][15][16] Mužjaci i ženke podvrgnute su standardiziranom fenotipskom pregledu kako bi se utvrdili efekti delecija.^[10][17] Obavljeno je 25 testova i prijavljena su dva nenormalna fenotipa. Tokom gestacije identifikovan je smanjen broj homozigotnih mutantnih embriona, a nijedan nije preživio do odbijanja. Preostali testovi su obavljeni na heterozigot nimmutantnim odraslim miševima i kod ovih životinja nisu uočene značajne abnormalnosti.^[10]

Interakcije

Pokazalo se da HDAC1 interraguje sa:

• Androgeni receptor,^[18]
• BCL6,^[19][20]
• BTG2,^[21][22]
• BUB1B,^[23]
• BUB1,^[23]
• BUB3,^[23]
• CBFA2T3,^[24][25]
• CDC20,^[23]
• CDH1,^[23]
• CHD3,^[26][27]
• CHD4,^[26][28][29]
• COUP-TFII,^[30]
• CTBP1,^[31][32][33]
• DDX17,^[34]
• DDX5,^[34]
• DNMT3A,^[35]
• DNMT3L,^[36][37]
• DAP6,^[38]
• EED,^[39]
• EVI1,^[40][41]
• EZH2,^[39]
• FKBP3,^[42]
• GATA1,^[43]
• HMG20B,^[44]
• HSPA4,^[45]
• HUS1,^[46]
• HD2,^{[26][28][39][44][45][47][48][49][50][51][52][53][54]}
• TGIF1,^[31][55]
• HCFC1,^[56]
• IFRD1,^[57]
• IKZF1,^[58][59]
• ING1,^[27][60]
• MBD3,^[52][61][62]
• MIER1,^[63]
• MLL,^[64]
• MTA1,^[28][65]
• MTA2,^{[28][52][66][67]}
• Mad1,^[23]
• Mdm2,^[68]
• CPGBP2,^[52][69][70]
• MADH2,^[71]
• MyoD,^[72][73]
• NFKB1,^[74]
• NRCR2,^[47][75]
• P21,^[76]
• PCNA,^[77]
• PHF21A,^[44][78]
• Prohibitin,^[79][80]
• PLP,^[81][82]
• RAD9A,^[46]
• RBBP4,^{[28][29][52][53][54][66][69][83][84][85][86]}
• RBBP7,^{[28][52][54][69]}
• RCOR1,^[44][66]
• RELA,^[51][74][87]
• RFC1,^[88]
• Retinoblastoma protein,^{[72][80][89][90][91][92][93]}
• RMP1,^[89][90]
• RMP2,^[89][94]
• SAP30,^{[27][52][95][96][97][98]}
• SATB1,^[67]
• SIN3A,^{[26][27][28][29][52][53][66][67][83][84][99][100][101][102]}
• SIN3B,^[52][58]
• SPEN,^[103]
• SUDS3,^[99][104]
• SUV39H1,^[105]
• STF,^{[84][106][107][108]}
• TOP2A,^[109][110]
• TOP2B,^[109][110] i
• ZFBTB16.^{[19][111][112]}

Također pogledajte

• Histon-deacetilaza
• Inhibitor histon-deacetilaze

Reference

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• HDAC1 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)

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