PBX1

PBX1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1B72, 1PUF

Identifikatori
AliasiPBX1
Vanjski ID-jeviOMIM: 176310 MGI: 97495 HomoloGene: 20574 GeneCards: PBX1
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za PBX1
Genomska lokacija za PBX1
Bend1q23.3Početak164,555,584 bp[1]
Kraj164,899,296 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za PBX1
Genomska lokacija za PBX1
Bend1 H2.3|1 75.95 cMPočetak167,946,933 bp[2]
Kraj168,259,839 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija sequence-specific DNA binding
GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
protein heterodimerization activity
GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
vezivanje sa DNK
GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
transcription factor binding
GO:0001948, GO:0016582 vezivanje za proteine
RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta citoplazma
jedro
transcription regulator complex
nukleoplazma
RNA polymerase II transcription regulator complex
Biološki proces anterior/posterior pattern specification
proximal/distal pattern formation
positive regulation of G2/M transition of mitotic cell cycle
embryonic organ development
embryonic hemopoiesis
negative regulation of DNA-binding transcription factor activity
transcription, DNA-templated
sex differentiation
multicellular organism development
embryonic limb morphogenesis
somatic stem cell population maintenance
regulation of cell population proliferation
adrenal gland development
spleen development
thymus development
positive regulation of cell population proliferation
urogenital system development
GO:0009373 regulation of transcription, DNA-templated
regulation of ossification
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
transcription by RNA polymerase II
negative regulation of neuron differentiation
embryonic skeletal system development
branching involved in ureteric bud morphogenesis
steroid biosynthetic process
Ćelijska diferencijacija
animal organ morphogenesis
positive regulation of transcription of Notch receptor target
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001204961
NM_001204963
NM_002585
NM_001353130
NM_001353131

NM_001291508
NM_001291509
NM_008783
NM_183355

RefSeq (bjelančevina)

NP_001191890
NP_001191892
NP_002576
NP_001340059
NP_001340060

NP_001278437
NP_001278438
NP_032809
NP_899198

Lokacija (UCSC)Chr 1: 164.56 – 164.9 MbChr 1: 167.95 – 168.26 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Pre-B-ćelijski leukemijski transkripcijski faktor 1 jest protein koji je kod ljudi kodiran genom PBX1 sa hromosoma 1.[5]

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 430 aminokiselina, a molekulska težina 46.626 Da.[6]

1020304050
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQI
MTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEP
TDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDY
RAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERM
VSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNE
YFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQE
EANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSV
QSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGIS
ANGGWQDATTPSSVTSPTEGPGSVHSDTSN

Interakcije

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Pokazano je da PBX1 ima interakcije sa:

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185630 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052534 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PBX1 Pre-B-cell leukemia homeobox 1".
  6. ^ "UniProt, P40424" (jezik: engleski). Pristupljeno 16. 12. 2021.
  7. ^ Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F (Mar 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". The EMBO Journal. 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. PMC 1170491. PMID 9482740.
  8. ^ Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C (Feb 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell. 96 (4): 587–97. doi:10.1016/S0092-8674(00)80662-5. PMID 10052460. S2CID 16122785.
  9. ^ Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (Mar 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes & Development. 9 (6): 663–74. doi:10.1101/gad.9.6.663. PMID 7729685.
  10. ^ Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. doi:10.1128/MCB.19.4.3051. PMC 84099. PMID 10082572.
  11. ^ Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology. 19 (11): 7577–88. doi:10.1128/MCB.19.11.7577. PMC 84774. PMID 10523646.
  12. ^ Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology. 19 (7): 5134–42. doi:10.1128/MCB.19.7.5134. PMC 84356. PMID 10373562.
  13. ^ Zubair M, Ishihara S, Oka S, Okumura K, Morohashi K (Jun 2006). "Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1". Molecular and Cellular Biology. 26 (11): 4111–21. doi:10.1128/MCB.00222-06. PMC 1489093. PMID 16705164.

Dopunska literatura

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Vanjski linkovi

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