PMP-22 apoptozno srodni efektor p53 jest plazmamembranski protein koji je kod ljudi kodiran genom PERP .[ 5] [ 6]
Dužina polipeptidnog lanca je 193 aminokiseline , а molekulska težina 21.386 Da .[ 7]
10 20 30 40 50 MIRCGLACER CRWILPLLLL SAIAFDIIAL AGRGWLQSSD HGQTSSLWWK CSQEGGGSGS YEEGCQSLME YAWGRAAAAM LFCGFIILVI CFILSFFALC GPQMLVFLRV IGGLLALAAV FQIISLVIYP VKYTQTFTLH ANPAVTYIYN WAYGFGWAAT IILIGCAFFF CCLPNYEDDL LGNAKPRYFY TSA
PERP je direktna transkripcijska meta p53 , ali se njegova transkripcija može regulirati i drugim faktorima transkripcije .[ 8]
PERP je važan za razvoj kože , a gubitak PERP-a povezan je s razvojem i progresijom nekoliko tipova ljudskih kancera .[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000112378 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019851 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hildebrandt T, Preiherr J, Tarbe N, Klostermann S, Van Muijen GN, Weidle UH (Dec 2000). "Identification of THW, a putative new tumor suppressor gene". Anticancer Res . 20 (5A): 2801–2809. PMID 11062687 . ^ "Entrez Gene: PERP PERP, TP53 apoptosis effector" .^ "UniProt, Q96FX8" (jezik: engleski). Pristupljeno 10. 10. 2021 .^ a b Roberts O, Paraoan L (Dec 2020). "PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP". Biochim Biophys Acta Rev Cancer . 1874 (1): 188393. doi :10.1016/j.bbcan.2020.188393 . PMID 32679166 . S2CID 220631324 .
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