CXCL5

CXCL5
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2MGS
Identifikatori
Aliasi	CXCL5
Vanjski ID-jevi	OMIM: 600324 MGI: 1096868 HomoloGene: 88672 GeneCards: CXCL5
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek)[1] Bend 4q13.3 Početak 73,995,642 bp[1] Kraj 73,998,677 bp[1]
Lokacija gena (miš) Hrom. Hromosom 5 (miš)[2] Bend 5 E1|5 44.78 cM Početak 90,907,219 bp[2] Kraj 90,909,483 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • CXCR chemokine receptor binding • cytokine activity • chemokine activity • vezivanje identičnih proteina Ćelijska komponenta • extracellular region • Vanćelijsko Biološki proces • positive regulation of cell population proliferation • inflammatory response • response to lipopolysaccharide • GO:0072468 Transdukcija signala • cell-cell signaling • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • chemokine-mediated signaling pathway • cell chemotaxis • neutrophil mediated immunity • Hemotaksija • defense response • positive regulation of neutrophil chemotaxis • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • neutrophil chemotaxis • leukocyte chemotaxis • antimicrobial humoral immune response mediated by antimicrobial peptide • cellular response to lipopolysaccharide Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6374	20311
Ensembl	ENSG00000163735	ENSMUSG00000029371
UniProt	P42830	P50228
RefSeq (mRNK)	NM_002994	NM_009141
RefSeq (bjelančevina)	NP_002985	NP_033167
Lokacija (UCSC)	Chr 4: 74 – 74 Mb	Chr 5: 90.91 – 90.91 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Citokinski ligand 5 (C-X-C motiv) jest protein koji je kod ljudi kodiran genom CXCL5 ili ENA78 sa hromosoma 4.^[5][6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 114 aminokiselina, а molekulska težina 11.972 Da.^[7]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSLLSSRAAR		VPGPSSSLCA		LLVLLLLLTQ		PGPIASAGPA		AAVLRELRCV
CLQTTQGVHP		KMISNLQVFA		IGPQCSKVEV		VASLKNGKEI		CLDPEAPFLK
KVIQKILDGG		NKEN

Funkcija

Protein kodiran ovim genom, CXCL5 je mali citokin u porodici CXC hemokina koji je također poznat kao peptid 78 (ENA-78) za aktiviranje neutrofila izvedenih iz epitela. Proizvodi se nakon stimulacije ćelija upalnim citokinima interleukinom-1 ili faktorom nekroze tumora-alfa.^[8] Ekspresija CXCL5 je također uočena kod eozinofila i može se inhibirati interferonskim tipom II IFN-γ.^[9] Ovaj hemokin stimulira hemotaksiju neutrofila koji imaju angiogena svojstva. Izaziva ove efekte interakcijom sa ćelijskom površinom hemokinskih receptora CXCR1 i CXCR2.^[9] Gen za CXCL5 kodira četiri egzona, a na hromosomu 4 nalazi se sa neloliko drugih hemokinskih gena.^[8][10] CXCL5 je uključen u remodeliranje vezivnog tkiva.^[9] Također je opisan kao regulator homeostaze neutrofila.^[11]

Klinički značaj

CXCL5 igra ulogu u smanjenju osjetljivosti na bol od opekotina kod nekih osoba i predstavlja "potencijalni cilj koji se može koristiti za razumijevanje više o boli kod drugih upalnih stanja kao što su artritis i cistitis.^[12] Poznato je da CXCL5 ima hemotaksijske i aktivirajuće funkcije na neutrofile, uglavnom tokom akutnih upalnih odgovora. Međutim, ekspresija CXCL5 je također veća u aterosklerozi (hronično upalno stanje), ali nije povezana s infiltracijom neutrofila. Umjesto toga, CXCL5 ima zaštitnu ulogu u aterosklerozi ,direktno kontrolirajući stvaranje makrofaga pjenaste ćelije.^[13]

Reference

1. GRCh38: Ensembl release 89: ENSG00000163735 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029371 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chang MS, McNinch J, Basu R, Simonet S (Nov 1994). "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene". J Biol Chem. 269 (41): 25277–82. doi:10.1016/S0021-9258(18)47243-2. PMID 7929219.
6. "Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5".
7. "UniProt, P42830" (jezik: engleski). Pristupljeno 23. 10. 2021.
8. Chang MS, McNinch J, Basu R, Simonet S (1994). "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene". J. Biol. Chem. 269 (41): 25277–82. doi:10.1016/S0021-9258(18)47243-2. PMID 7929219.
9. Persson T, Monsef N, Andersson P, Bjartell A, Malm J, Calafat J, Egesten A (2003). "Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils". Clin. Exp. Allergy. 33 (4): 531–7. doi:10.1046/j.1365-2222.2003.01609.x. PMID 12680872. S2CID 2449190.
10. O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet. Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.
11. Mei J, Liu Y, Dai N, Hoffmann C, Hudock KM, Zhang P, Guttentag SH, Kolls JK, Oliver PM, Bushman FD, Worthen GS (2012). "Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice". Journal of Clinical Investigation. 122 (3): 974–986. doi:10.1172/JCI60588. PMC 3287232. PMID 22326959.
12. Dawes JM, Calvo M, Perkins JR, Paterson KJ, Kiesewetter H, Hobbs C, Kaan TK, Orengo C, Bennett DL, McMahon SB (juli 2011). "CXCL5 Mediates UVB Irradiation-Induced Pain". Sci Transl Med. 3 (90): 90ra60. doi:10.1126/scitranslmed.3002193. PMC 3232447. PMID 21734176. Sažetak – FierceBiotech.
13. Rousselle A, Qadri F, Leukel L, Yilmaz R, Fontaine JF, Sihn G, Bader M, Ahluwalia A, Duchene J (2013). "CXCL5 limits macrophage foam cell formation in atherosclerosis". Journal of Clinical Investigation. 123 (3): 1343–7. doi:10.1172/JCI66580. PMC 3582141. PMID 23376791.

Dopunska literatura

• Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A (2007). "A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5". J. Immunol. 179 (7): 4849–56. doi:10.4049/jimmunol.179.7.4849. PMC 3696729. PMID 17878384.
• Walz A, Schmutz P, Mueller C, Schnyder-Candrian S (1997). "Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease". J. Leukoc. Biol. 62 (5): 604–11. doi:10.1002/jlb.62.5.604. PMID 9365115. S2CID 20141618.
• Struyf S, Proost P, Van Damme J (2004). "Regulation of the immune response by the interaction of chemokines and proteases". Adv. Immunol. Advances in Immunology. 81: 1–44. doi:10.1016/S0065-2776(03)81001-5. ISBN 978-0-12-022481-4. PMID 14711052.
• Walz A, Burgener R, Car B, et al. (1992). "Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8". J. Exp. Med. 174 (6): 1355–62. doi:10.1084/jem.174.6.1355. PMC 2119025. PMID 1744577.
• Power CA, Furness RB, Brawand C, Wells TN (1995). "Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets". Gene. 151 (1–2): 333–4. doi:10.1016/0378-1119(94)90682-3. PMID 7828901.
• Corbett MS, Schmitt I, Riess O, Walz A (1995). "Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78)". Biochem. Biophys. Res. Commun. 205 (1): 612–7. doi:10.1006/bbrc.1994.2709. PMID 7999089.
• Koch AE, Kunkel SL, Harlow LA, et al. (1994). "Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis". J. Clin. Invest. 94 (3): 1012–8. doi:10.1172/JCI117414. PMC 295150. PMID 8083342.
• Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). "Chemokine and chemokine receptor mRNA expression in human platelets". Cytokine. 7 (6): 479–82. doi:10.1006/cyto.1995.0065. PMID 8580362.
• Ahuja SK, Murphy PM (1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor". J. Biol. Chem. 271 (34): 20545–50. doi:10.1074/jbc.271.34.20545. PMID 8702798.
• Keates S, Keates AC, Mizoguchi E, et al. (1997). "Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis". Am. J. Physiol. 273 (1 Pt 1): G75–82. doi:10.1152/ajpgi.1997.273.1.G75. PMID 9252512.
• Wuyts A, Proost P, Lenaerts JP, et al. (1998). "Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78". Eur. J. Biochem. 255 (1): 67–73. doi:10.1046/j.1432-1327.1998.2550067.x. PMID 9692902.
• Wyrick PB, Knight ST, Paul TR, et al. (1999). "Persistent chlamydial envelope antigens in antibiotic-exposed infected cells trigger neutrophil chemotaxis". J. Infect. Dis. 179 (4): 954–66. doi:10.1086/314676. PMID 10068592.
• Wuyts A, Govaerts C, Struyf S, et al. (1999). "Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms". Eur. J. Biochem. 260 (2): 421–9. doi:10.1046/j.1432-1327.1999.00166.x. PMID 10095777.
• Hogaboam CM, Bone-Larson CL, Steinhauser ML, et al. (1999). "Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines". FASEB J. 13 (12): 1565–74. doi:10.1096/fasebj.13.12.1565. hdl:2027.42/154508. PMID 10463948. S2CID 7043800.
• Luu NT, Rainger GE, Nash GB (2000). "Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils". J. Immunol. 164 (11): 5961–9. doi:10.4049/jimmunol.164.11.5961. PMID 10820279.
• Crane IJ, Wallace CA, McKillop-Smith S, Forrester JV (2000). "Control of chemokine production at the blood–retina barrier". Immunology. 101 (3): 426–33. doi:10.1046/j.0019-2805.2000.01105.x. PMC 2327097. PMID 11106948.
• Zhang C, Thornton MA, Kowalska MA, et al. (2001). "Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus". Blood. 98 (3): 610–7. doi:10.1182/blood.V98.3.610. PMID 11468158.
• Chandrasekar B, Melby PC, Sarau HM, et al. (2003). "Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway". J. Biol. Chem. 278 (7): 4675–86. doi:10.1074/jbc.M207006200. PMID 12468547.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Vanjski linkovi

• Lokacija ljudskog genoma CXCL5 i stranica sa detaljima o genu CXCL5 u UCSC Genome Browseru.