La dodicesima cerimonia del Premio SAG si è svolta il 29 gennaio 2006 allo Shrine Exposition Center di Los Angeles.
- Crash - Contatto fisico
Chris "Ludacris" Bridges, Sandra Bullock, Don Cheadle, Matt Dillon, Jennifer Esposito, William Fichtner, Brendan Fraser, Terrence Howard, Thandie Newton, Ryan Phillippe, Larenz Tate
- Good Night, and Good Luck.
Rose Abdoo, Alex Borstein, Robert John Burke, Patricia Clarkson, George Clooney, Jeff Daniels, Reed Diamond, Tate Donovan, Robert Downey Jr., Grant Heslov, Peter Jacobson, Frank Langella, Tom McCarthy, Dianne Reeves, Matt Ross, David Strathairn, Ray Wise
- Hustle & Flow - Il colore della musica (Hustle & Flow)
Anthony Anderson, Chris "Ludacris" Bridges, Isaac Hayes, Taraji P. Henson, Terrence Howard, Taryn Manning, Elise Neal, Paula Jai Parker, D.J. Qualls
- I segreti di Brokeback Mountain
Linda Cardellini, Anna Faris, Jake Gyllenhaal, Anne Hathaway, Heath Ledger, Randy Quaid, Michelle Williams
- Truman Capote - A sangue freddo
Bob Balaban, Marshall Bell, Clifton Collins Jr., Chris Cooper, Bruce Greenwood, Philip Seymour Hoffman, Catherine Keener, Mark Pellegrino
- Lost
Adewale Akinnuoye-Agbaje, Naveen Andrews, Emilie de Ravin, Matthew Fox, Jorge Garcia, Maggie Grace, Josh Holloway, Malcolm David Kelley, Daniel Dae Kim, Yunjin Kim, Evangeline Lilly, Dominic Monaghan, Terry O'Quinn, Harold Perrineau, Michelle Rodriguez, Ian Somerhalder, Cynthia Watros
- Grey's Anatomy
Justin Chambers, Patrick Dempsey, Katherine Heigl, T.R. Knight, Sandra Oh, James Pickens Jr., Ellen Pompeo, Kate Walsh, Isaiah Washington, Chandra Wilson
- Six Feet Under
Lauren Ambrose, Joanna Cassidy, Frances Conroy, James Cromwell, Rachel Griffiths, Michael C. Hall, Tina Holmes, Peter Krause, Justina Machado, Freddy Rodríguez, Jeremy Sisto, Mathew St. Patrick
- The Closer
G. W. Bailey, Michael Paul Chan, Raymond Cruz, Gina Ravera, Tony Denison, Robert Gossett, Corey Reynolds, Kyra Sedgwick, J.K. Simmons, Jon Tenney
- West Wing - Tutti gli uomini del Presidente
Alan Alda, Kristin Chenoweth, Janeane Garofalo, Dulé Hill, Allison Janney, Joshua Malina, Mary McCormack, Janel Moloney, Teri Polo, Richard Schiff, Martin Sheen, Jimmy Smits, John Spencer, Bradley Whitford
- Desperate Housewives
Andrea Bowen, Mehcad Brooks, Ricardo Antonio Chavira, Marcia Cross, Steven Culp, James Denton, Teri Hatcher, Felicity Huffman, Brent Kinsman, Shane Kinsman, Eva Longoria, Mark Moses, Doug Savant, Nicollette Sheridan, Brenda Strong, Alfre Woodard
- Arrested Development
Will Arnett, Jason Bateman, Michael Cera, David Cross, Portia De Rossi, Tony Hale, Alia Shawkat, Jeffrey Tambor, Jessica Walter
- Boston Legal
René Auberjonois, Ryan Michelle Bathe, Candice Bergen, Julie Bowen, Justin Mentell, Rhona Mitra, Monica Potter, William Shatner, James Spader, Mark Valley
- Curb Your Enthusiasm
Shelley Berman, Larry David, Susie Essman, Jeff Garlin, Cheryl Hines, Richard Lewis
- Tutti amano Raymond
Peter Boyle, Brad Garrett, Patricia Heaton, Doris Roberts, Ray Romano, Madylin Sweeten
- My Name Is Earl
Jason Lee, Jaime Pressly, Eddie Steeples, Ethan Suplee, Nadine Velazquez