PEPA je ampakinski lek koji deluje kao alosterni potencijator desenzitizacije AMPA receptora.[3][4] On je oko 100 puta potentniji od aniracetama in vitro.[5] It produces memory-enhancing effects in rats when administered intravenously.[6]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Sekiguchi M, Takeo J, Harada T, Morimoto T, Kudo Y, Yamashita S, Kohsaka S, Wada K (1998). „Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures”. British Journal of Pharmacology 123 (7): 1294–303. DOI:10.1038/sj.bjp.0701707. PMC 1565288. PMID 9579722.
- ↑ Sekiguchi (2002). „A desensitization-selective potentiator of AMPA-type glutamate receptors”. British Journal of Pharmacology 136 (7): 1033–41. DOI:10.1038/sj.bjp.0704804. PMC 1573432. PMID 12145103.
- ↑ Sekiguchi, M; Fleck, MW; Mayer, ML; Takeo, J; Chiba, Y; Yamashita, S; Wada, K (1997). „A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide”. Journal of Neuroscience 17 (15): 5760–71. PMID 9221774.
- ↑ Sekiguchi, M; Yamada, K; Jin, J; Hachitanda, M; Murata, Y; Namura, S; Kamichi, S; Kimura, I et al (2001). „The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment”. NeuroReport 12 (13): 2947–50. DOI:10.1097/00001756-200109170-00038. PMID 11588608.
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| Agonisti: Konkurentni agonisti: Aspartat • Glutamat • Homokinolinska kiselina • Ibotenska kiselina • NMDA • Kinolinska kiselina • Tetrazolilglicin; Agonisti glicinskog mesta: ACBD • ACPC • ACPD • Alanin • CCG • Cikloserin • DHPG • Fluoroalanin • Glicin • HA-966 • L-687,414 • Milacemid • Sarkozin • Serin • Tetrazolilglicin; Agonisti poliaminskog mesta: Akamprosat • Spermidin • SperminAntagonisti: Konkurentni antagonisti: AP5 (APV) • AP7 • CGP-37849 • CGP-39551 • CGP-39653 • CGP-40116 • CGS-19755 • CPP • LY-233,053 • LY-235,959 • LY-274,614 • MDL-100,453 • Midafotel (d-CPPen) • NPC-12,626 • NPC-17,742 • PBPD • PEAQX • Perzinfotel • PPDA • SDZ-220581 • Selfotel; Nekonkurentni antagonisti: ARR-15,896 • Karoverin • Deksanabinol • FPL-12495 • FR-115,427 • Hodgkinsin • Magnezijum • MDL-27,266 • NPS-1506 • Psihotridin • Cink; Nekonkurentni blokatori pora: 2-MDP • 3-MeO-PCP • 8A-PDHQ • Amantadin • Aptiganel • ARL-12,495 • ARL-15,896-AR • ARL-16,247 • Budipin • Delucemin • Deksoksadrol • Dekstralorfan • Dieticiklidin • Dizocilpin • Endopsihozin • Esketamin • Etoksadrol • Eticiklidin • Gaciklidin • Ibogain • Indantadol • Ketamin • Ketobemidon • Loperamid • Memantin • Meperidin (Petidin) • Metadon • Metorfan ( Dekstrometorfan, Levometorfan) • Metoksetamin • Milnacipran • Morfanol ( Dekstrorfan, Levorfanol) • NEFA • Nerameksan • Azotsuboksid • Noribogain • Orfenadrin • PCPr • Fenciklamin • Fenciklidin • Propoksifen • Remacemid • Rinhofilin • Riluzol • Rimantadin • Roliciklidin • Sabeluzol • Tenociklidin • Tiletamin • Tramadol • Ksenon; Antagonisti glicinskog mesta: ACEA-1021 • ACEA-1328 • ACPC • Karisoprodol • CGP-39653 • CKA • DCKA • Felbamat • Gavestinel • GV-196,771 • Kinurenska kiselina • L-689,560 • L-701,324 • Lakosamid • Likostinel • LU-73,068 • MDL-105,519 • Meprobamat • MRZ 2/576 • PNQX • ZD-9379; Antagonisti NR2B podjedinice: Bezonprodil • CO-101,244 (PD-174,494) • CP-101,606 • Eliprodil • Haloperidol • Ifenprodil • Izoksuprin • Nilidrin • Ro8-4304 • Ro25-6981 • Traksoprodil; Neklasifikovani/nesortirani antagonisti: Hloroform • Dietil etar • Enfluran • Etanol (Alkohol) • Halotan • Izofluran • Metoksifluran • Toluen • Trihloroetan • Trihloroetanol • Trihloroetilen • Ksilen |
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