Dimemorfan

Dimemorfan
IUPAC ime
(9α,13α,14α)-3,17-dimethylmorphinan
Identifikatori
CAS broj36309-01-0 ДаY
ATC kodR05DA11 (WHO)
PubChemCID 3037918
ChemSpider16735785 ДаY
KEGGD07848
Hemijski podaci
FormulaC18H25N
Molarna masa255.398 g/mol
  • Cc3ccc4C[C@@H]1N(C)CC[C@]2(CCCC[C@H]12)c4c3
  • InChI=1S/C18H25N/c1-13-6-7-14-12-17-15-5-3-4-8-18(15,16(14)11-13)9-10-19(17)2/h6-7,11,15,17H,3-5,8-10,12H2,1-2H3/t15-,17+,18+/m1/s1 ДаY
  • Key:KBEZZLAAKIIPFK-NJAFHUGGSA-N ДаY

Dimemorfan je antitusivni lek (supresant kašlja) koji deluje kao agonist sigma receptor.[1][2] On je analog dekstrometorfana i dekstrorfana, ali deluje kao antagonist NMDA receptora i nema disocijativne efekte, čime je umanjen njegov potencijal za zloupotrebu, kao i nuspojave.[3]

Vidi još

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Reference

[уреди | уреди извор]
  1. ^ Hui-Hung Wang, Jyh-Wei Chien, Yueh-Ching Chou, Jyh-Fei Liao and Chieh-Fu Chen. Anti-amnesic effect of dimemorfan in mice. British Journal of Pharmacology (2003) 138, 941–949.
  2. ^ Eun-Joo Shin, Seung-Yeol Nah, Won-Ki Kim, Kwang Ho Ko, Wang-Kee Jhoo, Yong-Kwang Lim, Joo Young Cha, Chieh-Fu Chen and Hyoung-Chun Kim. The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. British Journal of Pharmacology (2005) 144, 908–918.
  3. ^ Chou YC, Liao JF, Chang WY, Lin MF, Chen CF (1999). „Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan”. Brain Research. 821 (2): 516—9. PMID 10064839. doi:10.1016/S0006-8993(99)01125-7. 


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