CCL3

CCL3
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1B50, 1B53, 2X69, 2X6G, 3FPU, 3H44, 3KBX, 4RA8, 4ZKB, 5D65, 5COR
Identifikatori
Aliasi	CCL3
Vanjski ID-jevi	OMIM: 182283 MGI: 98260 HomoloGene: 88430 GeneCards: CCL3
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek)[1] Bend 17q12 Početak 36,088,256 bp[1] Kraj 36,090,169 bp[1]
Lokacija gena (miš) Hrom. Hromosom 11 (miš)[2] Bend 11 C|11 51.04 cM Početak 83,538,670 bp[2] Kraj 83,540,181 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • protein kinase activity • cytokine activity • CCR5 chemokine receptor binding • chemokine activity • CCR1 chemokine receptor binding • kinase activity • phospholipase activator activity • calcium-dependent protein kinase C activity • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje identičnih proteina • chemoattractant activity • CCR chemokine receptor binding Ćelijska komponenta • citoplazma • citosol • intracellular anatomical structure • extracellular region • Vanćelijsko Biološki proces • G protein-coupled receptor signaling pathway • signaling • negative regulation of bone mineralization • positive regulation of protein kinase B signaling • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • response to cholesterol • positive regulation of calcium-mediated signaling • regulation of sensory perception of pain • protein kinase B signaling • monocyte chemotaxis • negative regulation of osteoclast differentiation • astrocyte cell migration • positive regulation of cell migration • positive regulation of natural killer cell chemotaxis • chemokine-mediated signaling pathway • T cell chemotaxis • cell-cell signaling • cellular response to tumor necrosis factor • eosinophil chemotaxis • GO:1904579 cellular response to organic cyclic compound • cellular calcium ion homeostasis • negative regulation of gene expression • neutrophil chemotaxis • cell activation • MAPK cascade • Hemotaksija • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • positive regulation of neuron apoptotic process • positive regulation of calcium ion import • macrophage chemotaxis • GO:1901313 positive regulation of gene expression • cytoskeleton organization • osteoblast differentiation • cellular response to interleukin-1 • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • positive regulation of ERK1 and ERK2 cascade • regulation of cell shape • positive regulation of tumor necrosis factor production • cellular response to interferon-gamma • lymphocyte chemotaxis • inflammatory response • granulocyte chemotaxis • response to toxic substance • eosinophil degranulation • lipopolysaccharide-mediated signaling pathway • calcium ion transport • calcium-mediated signaling • Egzocitoza • positive regulation of calcium ion transport • positive chemotaxis • positive regulation of inflammatory response • regulation of signaling receptor activity • cytokine-mediated signaling pathway • regulation of behavior • positive regulation of microglial cell activation • positive regulation of microglial cell migration Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6348	20302
Ensembl	ENSG00000278567 ENSG00000277632 ENSG00000274221	ENSMUSG00000000982
UniProt	P10147	P10855
RefSeq (mRNK)	NM_002983	NM_011337
RefSeq (bjelančevina)	NP_002974	NP_035467
Lokacija (UCSC)	Chr 17: 36.09 – 36.09 Mb	Chr 11: 83.54 – 83.54 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Hemokinski (C-C motivni) ligand 3 (CCL3), znan i kao makrofagni upalni protein 1-alfa (MIP-1-alfa) je protein koji je kod ljudi kodiran genom CCL.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 92 aminokiseline, a molekulska težina 10.085 Da.^[6].

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MQVSTAALAV		LLCTMALCNQ		FSASLAADTP		TACCFSYTSR		QIPQNFIADY
FETSSQCSKP		GVIFLTKRSR		QVCADPSEEW		VQKYVSDLEL		SA

Funkcija

CCL3 je citokin koji pripada porodici CC hemokina koji su uključeni u akutno upalno stanje u regrutovanju i aktivaciji polimorfojedarnih leukocita^[7] vezanjem na receptore CCR1, CCR4 i CCR5.^[5]

Sherry et al. (1988) demonstrirali su dvije proteinske komponente MIP1, koje se nazivaju alfa (CCL3, ovaj protein) i beta (CCL4).^[5][8]

CCL3 izaziva monofaznu groznicu brzog početka, čija je magnituda jednaka ili veća od groznice proizvedene bilo s rekombinantnim ljudskim faktorom nekroze tumora ili rekombinantnim ljudskim interleukinom-1. Međutim, za razliku od ova dva endogena pirogena, inhibitor ciklooksigenaza ibuprofen inhibitor ibuprofen ne može inhibirati groznicu izazvanu MIP-1, a CCL3 može učestvovati u upalnim odgovorom koji nije posredovan sintezom prostaglandina i klinički se ne može ablirati ciklooksigenazom.^[9]

Interakcije

Pokazano je da CCL3 komunicira sa CCL4.^[10] Privlači makrofage, monocite i neutrofile.

Također pogledajte

• Makrofagni upalni proteini

Reference

1. ENSG00000277632, ENSG00000274221 GRCh38: Ensembl release 89: ENSG00000278567, ENSG00000277632, ENSG00000274221 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000982 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3".
6. "UniProt, P10147". Pristupljeno 26. 6. 2021.
7. Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A (1988). "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties". The Journal of Experimental Medicine. 167 (2): 570–81. doi:10.1084/jem.167.2.570. PMC 2188834. PMID 3279154.
8. Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A (1988). "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". The Journal of Experimental Medicine. 168 (6): 2251–9. doi:10.1084/jem.168.6.2251. PMC 2189160. PMID 3058856.
9. Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A (1989). "Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen". Science. 243 (4894 Pt 1): 1066–8. doi:10.1126/science.2646711. PMID 2646711.
10. Guan E, Wang J, Norcross MA (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.

Dopunska literatura

• Menten P, Wuyts A, Van Damme J (Dec 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.
• Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (Apr 2004). "HIV-1 Vpr and anti-inflammatory activity". DNA and Cell Biology. 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381.
• Joseph AM, Kumar M, Mitra D (Jan 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
• Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
• Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID 15817944.
• Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.

Vanjski linkovi

• Lokacija ljudskog genoma CCL3 i stranica sa detaljima o genu CCL3 u UCSC Genome Browseru.