Lu AA-33810

Lu AA-33810
IUPAC ime
	N-[(trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl)methyl]methanesulfonamide
Identifikatori
ATC kod	None
PubChem	CID 22254068
Sinonimi	Lu AA-33810
Hemijski podaci
Formula	C19H25N3O2S3
Molarna masa	423.615 g/mol
	SMILES O=S(C)(=O)NCC3CCC(CC3)Nc4sc2CCSc1ccccc1-c2n4; ;

Lu AA-33810 je potentan i visoko selektivan antagonist neuropeptid Y receptora Y₅, sa Ki vrednošću od 1.5 nM. On je 3300x selektivniji za ovaj receptor nego za Y₁, Y₂ i Y₄ receptore. U životinjskim studijama on proizvodi anoreksne, antidepresantne i anksiolitske efekte. Dalja istraživanja se sprovode s ciljem njegovog njegove primene kao potencijalnog leka za poremećaje ishrane.^[1] Ovaj lek je razvila kompanija Lundbeck.

Literatura

^ Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA (2009). „The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 (N-([trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl)-methanesulfonamide) exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity”. The Journal of Pharmacology and Experimental Therapeutics. 328 (3): 900—11. PMID 19098165. doi:10.1124/jpet.108.144634.

Spoljašnje veze

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[pmid19098165-1] Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA (2009). „The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 (N-([trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl)-methanesulfonamide) exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity”. The Journal of Pharmacology and Experimental Therapeutics. 328 (3): 900—11. PMID 19098165. doi:10.1124/jpet.108.144634.

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