Arginin vazopresinski receptor 2

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Identifikatori
Simboli	AVPR2; ADHR; DI1; DIR; DIR3; MGC126533; MGC138386; NDI; V2R
Vanjski ID	OMIM: 300538 MGI: 88123 HomoloGene: 20064 IUPHAR: V2 GeneCards: AVPR2 Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu sličnog receptora • receptorska aktivnost Celularna komponenta • integralno sa ćelijskom membranom • membrana • endosom • endoplazmatičnin retikulum • Goldžijev aparat • ćelijska membrana Biološki proces • prenos signal • signalni put G-protein spregnutog receptora • G-protein signalizacija, spregnuta sa cAMP nukleotidnim sekundarnim glasnikom • aktivacija adenilat ciklaze • eksrecija • hemostaza • biološki_proces
Ortolozi
Vrsta	Čovek	Miš
Entrez	554	12000
Ensembl	ENSG00000126895	ENSMUSG00000031390
UniProt	P30518	Q3KNZ4
RefSeq (mRNA)	NM_000054	NM_019404
RefSeq (protein)	NP_000045	NP_062277
Lokacija (UCSC)	Chr X: 152.82 - 152.83 Mb	Chr X: 70.13 - 70.15 Mb
PubMed pretraga	[1]	[2]

Arginin vazopresinski receptor 2 (AVPR2) je protein koji deluje receptor za arginin vazopresin.^[1] AVPR2 pripada familiji G protein-spregnutih receptora. Njegovo dejstvo je posredovano G_s tipom G proteina, koji stimuliše adenilat ciklazu.

Antagonisti

Selektivni antagonisti vazopresinskog receptora su:

• Tolvaptan (FDA-odobren)
• Liksivaptan
• Mozavaptan
• Satavaptan

Njihova glavna upotreba je lečenje hiponatremije, koja može da bude izazvana sindromom neodgovarajućeg izlučivanja antidiuretskog hormona (SIADH) i cirozom.

Interakcije

Za arginin vazopresinski receptor 2 je bilo pokazano da interaguje sa C1QTNF1.^[2]

Reference

1. van den Ouweland AM, Knoop MT, Knoers VV, Markslag PW, Rocchi M, Warren ST, Ropers HH, Fahrenholz F, Monnens LA, van Oost BA (1992). „Colocalization of the gene for nephrogenic diabetes insipidus (DIR) and the vasopressin type 2 receptor gene (AVPR2) in the Xq28 region”. Genomics 13 (4): 1350–2. DOI:10.1016/0888-7543(92)90067-3. PMID 1324225. 
2. Innamorati, Giulio; Whang Michael Insuk, Molteni Raffaella, Le Gouill Christian, Birnbaumer Mariel (November 2002). „GIP, a G-protein-coupled receptor interacting protein”. Regul. Pept. (Netherlands) 109 (1–3): 173–9. DOI:10.1016/S0167-0115(02)00201-X. ISSN 0167-0115. PMID 12409230. 

Literatura

• Birnbaumer M (2001). „The V2 vasopressin receptor mutations and fluid homeostasis”. Cardiovasc. Res. 51 (3): 409–15. DOI:10.1016/S0008-6363(01)00337-6. PMID 11476731. 
• Ishikawa SE (2002). „[Nephrogenic diabetes insipidus associated with mutations of vasopressin V2 receptors and aquaporin-2]”. Nippon Rinsho 60 (2): 350–5. PMID 11857925. 
• Thibonnier M, Coles P, Thibonnier A, Shoham M (2002). „Molecular pharmacology and modeling of vasopressin receptors”. Prog. Brain Res. 139: 179–96. DOI:10.1016/S0079-6123(02)39016-2. PMID 12436935. 
• Bichet DG (2006). „Nephrogenic diabetes insipidus”. Advances in chronic kidney disease 13 (2): 96–104. DOI:10.1053/j.ackd.2006.01.006. PMID 16580609. 
• Robben JH, Knoers NV, Deen PM (2006). „Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus”. Am. J. Physiol. Renal Physiol. 291 (2): F257–70. DOI:10.1152/ajprenal.00491.2005. PMID 16825342. 
• Pan Y, Metzenberg A, Das S, et al. (1993). „Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus”. Nat. Genet. 2 (2): 103–6. DOI:10.1038/ng1092-103. PMID 1303257. 
• van den Ouweland AM, Dreesen JC, Verdijk M, et al. (1993). „Mutations in the vasopressin type 2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus”. Nat. Genet. 2 (2): 99–102. DOI:10.1038/ng1092-99. PMID 1303271. 
• van den Ouweland AM, Knoop MT, Knoers VV, et al. (1992). „Colocalization of the gene for nephrogenic diabetes insipidus (DIR) and the vasopressin type 2 receptor gene (AVPR2) in the Xq28 region”. Genomics 13 (4): 1350–2. DOI:10.1016/0888-7543(92)90067-3. PMID 1324225. 
• Rosenthal W, Seibold A, Antaramian A, et al. (1992). „Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus”. Nature 359 (6392): 233–5. DOI:10.1038/359233a0. PMID 1356229. 
• Seibold A, Brabet P, Rosenthal W, Birnbaumer M (1992). „Structure and chromosomal localization of the human antidiuretic hormone receptor gene”. Am. J. Hum. Genet. 51 (5): 1078–83. PMC 1682836. PMID 1415251. 
• Birnbaumer M, Seibold A, Gilbert S, et al. (1992). „Molecular cloning of the receptor for human antidiuretic hormone”. Nature 357 (6376): 333–5. DOI:10.1038/357333a0. PMID 1534149. 
• Lolait SJ, O'Carroll AM, McBride OW, et al. (1992). „Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus”. Nature 357 (6376): 336–9. DOI:10.1038/357336a0. PMID 1534150. 
• Knoers N, van der Heyden H, van Oost BA, et al. (1989). „Three-point linkage analysis using multiple DNA polymorphic markers in families with X-linked nephrogenic diabetes insipidus”. Genomics 4 (3): 434–7. DOI:10.1016/0888-7543(89)90352-2. PMID 2714800. 
• Tsukaguchi H, Matsubara H, Taketani S, et al. (1995). „Binding-, intracellular transport-, and biosynthesis-defective mutants of vasopressin type 2 receptor in patients with X-linked nephrogenic diabetes insipidus”. J. Clin. Invest. 96 (4): 2043–50. DOI:10.1172/JCI118252. PMC 185843. PMID 7560098. 
• Faà V, Ventruto ML, Loche S, et al. (1995). „Mutations in the vasopressin V2-receptor gene in three families of Italian descent with nephrogenic diabetes insipidus”. Hum. Mol. Genet. 3 (9): 1685–6. DOI:10.1093/hmg/3.9.1685. PMID 7833930. 
• Birnbaumer M, Gilbert S, Rosenthal W (1995). „An extracellular congenital nephrogenic diabetes insipidus mutation of the vasopressin receptor reduces cell surface expression, affinity for ligand, and coupling to the Gs/adenylyl cyclase system”. Mol. Endocrinol. 8 (7): 886–94. DOI:10.1210/me.8.7.886. PMID 7984150. 
• Wenkert D, Merendino JJ, Shenker A, et al. (1995). „Novel mutations in the V2 vasopressin receptor gene of patients with X-linked nephrogenic diabetes insipidus”. Hum. Mol. Genet. 3 (8): 1429–30. DOI:10.1093/hmg/3.8.1429. PMID 7987330. 
• Oksche A, Dickson J, Schülein R, et al. (1995). „Two novel mutations in the vasopressin V2 receptor gene in patients with congenital nephrogenic diabetes insipidus”. Biochem. Biophys. Res. Commun. 205 (1): 552–7. DOI:10.1006/bbrc.1994.2700. PMID 7999078. 
• Bichet DG, Birnbaumer M, Lonergan M, et al. (1994). „Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus”. Am. J. Hum. Genet. 55 (2): 278–86. PMC 1918376. PMID 8037205. 
• Yuasa H, Ito M, Oiso Y, et al. (1994). „Novel mutations in the V2 vasopressin receptor gene in two pedigrees with congenital nephrogenic diabetes insipidus”. J. Clin. Endocrinol. Metab. 79 (2): 361–5. DOI:10.1210/jc.79.2.361. PMID 8045948. 

Vanjske veze

• GeneReviews/NCBI/NIH/UW
• „Symbol Report: AVPR2”. Human Geneome Organization Gene Nomenclature Committee. Arhivirano iz originala na datum 2011-05-11. Pristupljeno 2014-05-08. 
• „Vasopressin and Oxytocin Receptors: V₂”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2014-03-01.