Neuropeptidni Y receptor Y2

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Neuropeptidni Y receptor Y2
Identifikatori
Simboli	NPY2R;
Vanjski ID	OMIM: 162642 MGI: 108418 HomoloGene: 701 IUPHAR: Y2 GeneCards: NPY2R Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • aktivnost peptidnog YY receptora • receptorska aktivnost • aktivnost regulatora kalcijumskog kanala Celularna komponenta • integralno sa ćelijskom membranom • membrana Biološki proces • prenos signala • signalni put G-protein spregnutog receptora • G-protein signalizacija, adenilat ciklazni inhibitorni put • cirkadijalni ritam • lokomotorno ponašanje • način ishrane
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	4887	18167
Ensembl	ENSG00000185149	ENSMUSG00000028004
UniProt	P49146	Q8BWV1
RefSeq (mRNA)	NM_000910	NM_008731
RefSeq (protein)	NP_000901	NP_032757
Lokacija (UCSC)	Chr 4: 156.35 - 156.36 Mb	Chr 3: 82.62 - 82.63 Mb
PubMed pretraga	[1]	[2]

Neuropeptidni Y receptor tip 2 je protein koji je kod ljudi kodiran NPY2R genom.^[1][2]

Selektivni ligandi

Agonisti

• Neuropeptid Y (endogeni agonist, nije podtip selektivan)
• Neuropeptidni Y fragment 13-36 (NPY₂ selektivni agonist)
• 2-Tiouridin 5'-trifosfat
• Peptid YY
• Peptid YY 3-36 fragment^[3]

Antagonisti

• BIIE-0246

Povezano

• Neuropeptidni Y receptor

Reference

1. Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (Nov 1995). „Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor”. J Biol Chem 270 (39): 22661–4. DOI:10.1074/jbc.270.39.22661. PMID 7559383. 
2. „Entrez Gene: NPY2R neuropeptide Y receptor Y2”. 
3. Murphy KG, Dhillo WS, Bloom SR (December 2006). „Gut peptides in the regulation of food intake and energy homeostasis”. Endocrine Reviews 27 (7): 719–27. DOI:10.1210/er.2006-0028. PMID 17077190. 

Literatura

• Wan CP, Lau BH (1997). „Neuropeptide Y receptor subtypes.”. Life Sci. 56 (13): 1055–64. DOI:10.1016/0024-3205(95)00041-4. PMID 9001438. 
• Parker E, Van Heek M, Stamford A (2002). „Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.”. Eur. J. Pharmacol. 440 (2-3): 173–87. DOI:10.1016/S0014-2999(02)01427-9. PMID 12007534. 
• Herzog H, Hort YJ, Ball HJ, et al. (1992). „Cloned human neuropeptide Y receptor couples to two different second messenger systems.”. Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5794–8. DOI:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422. 
• Gerald C, Walker MW, Vaysse PJ, et al. (1995). „Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.”. J. Biol. Chem. 270 (45): 26758–61. DOI:10.1074/jbc.270.45.26758. PMID 7592910. 
• Lynch JW, Lemos VS, Bucher B, et al. (1994). „A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line.”. J. Biol. Chem. 269 (11): 8226–33. PMID 8132547. 
• Gehlert DR, Beavers LS, Johnson D, et al. (1996). „Expression cloning of a human brain neuropeptide Y Y2 receptor.”. Mol. Pharmacol. 49 (2): 224–8. PMID 8632753. 
• Yan H, Yang J, Marasco J, et al. (1996). „Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.”. Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4661–5. DOI:10.1073/pnas.93.10.4661. PMC 39335. PMID 8643460. 
• Ammar DA, Eadie DM, Wong DJ, et al. (1997). „Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene.”. Genomics 38 (3): 392–8. DOI:10.1006/geno.1996.0642. PMID 8975716. 
• Snow BE, Hall RA, Krumins AM, et al. (1998). „GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.”. J. Biol. Chem. 273 (28): 17749–55. DOI:10.1074/jbc.273.28.17749. PMID 9651375. 
• Caberlotto L, Fuxe K, Rimland JM, et al. (1998). „Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain.”. Neuroscience 86 (1): 167–78. DOI:10.1016/S0306-4522(98)00039-6. PMID 9692752. 
• Goumain M, Voisin T, Lorinet AM, et al. (2001). „The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning.”. Mol. Pharmacol. 60 (1): 124–34. PMID 11408607. 
• Cox HM, Tough IR (2002). „Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.”. Br. J. Pharmacol. 135 (6): 1505–12. DOI:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964. 
• Uddman R, Möller S, Nilsson T, et al. (2003). „Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues.”. Peptides 23 (5): 927–34. DOI:10.1016/S0196-9781(02)00003-7. PMID 12084524. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Hyland NP, Sjöberg F, Tough IR, et al. (2004). „Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues.”. Br. J. Pharmacol. 139 (4): 863–71. DOI:10.1038/sj.bjp.0705298. PMC 1573894. PMID 12813010. 
• Hung CC, Pirie F, Luan J, et al. (2004). „Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.”. Diabetes 53 (9): 2461–6. DOI:10.2337/diabetes.53.9.2461. PMID 15331560. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 

Spoljašnje veze

• „Neuropeptide Y Receptors: Y₂”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.