Hinpirol
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| Nazivi | |
|---|---|
| IUPAC naziv
(4aR,8aR)-5-propil-4,4a,5,6,7,8,8a,9-oktahidro-1H-pirazolo[3,4-g]hinolin
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| Identifikacija | |
| Svojstva | |
| C13H21N3 | |
| Molarna masa | 219,33 g/mol |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
 verifikuj (šta je   ?)
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| Reference infokutije | |
Hinpirol je psihoaktivni lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni agonist D2 i D3 receptora.[3][4][5] Za hinpirol je pokazano da povećava lokomotornu aktivnost kod miševa. U jednoj studiji je nađeno da on indukuje kompulzivno ponašanje koje je simptomatično za opsesivno-kompulzivni poremećaj kod pacova.[6]
Reference
[уреди | уреди извор]- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Eilam D, Szechtman H (1989). „Biphasic effect of D-2 agonist quinpirole on locomotion and movements”. European Journal of Pharmacology. 161 (2–3): 151—7. PMID 2566488. doi:10.1016/0014-2999(89)90837-6.
- ^ Navarro JF, Maldonado E (1999). „Behavioral profile of quinpirole in agonistic encounters between male mice”. Methods and Findings in Experimental and Clinical Pharmacology. 21 (7): 477—80. PMID 10544391.
- ^ Culm KE, Lugo-Escobar N, Hope BT, Hammer RP (2004). „Repeated quinpirole treatment increases cAMP-dependent protein kinase activity and CREB phosphorylation in nucleus accumbens and reverses quinpirole-induced sensorimotor gating deficits in rats”. Neuropsychopharmacology. 29 (10): 1823—30. PMID 15138441. doi:10.1038/sj.npp.1300483.
- ^ Szechtman Henry; Sulis William; Eilam David (1998). „Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD)”. Behavioral Neuroscience. 112 (6): 1475—85. PMID 9926830. doi:10.1037/0735-7044.112.6.1475.
