Oreksinski receptor 1

Hipokretinski (oreksinski) receptor 1
Hipokretinski (oreksinski) receptor 1
Identifikatori
Simboli	HCRTR1; OX1R
Vanjski ID	OMIM: 602392 MGI: 2385650 HomoloGene: 37492 IUPHAR: OX1 GeneCards: HCRTR1 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost neuropeptidnog receptora; • aktivnost oreksinskog receptora;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • neuropeptidni signalni put; • sinapsna transmisija; • ishrana;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	3061
Ensembl	ENSG00000121764
UniProt	O43613
RefSeq (mRNA)	NM_001525
RefSeq (protein)	NP_001516
Lokacija (UCSC)	Chr 1:; 31.86 - 31.87 Mb
PubMed pretraga	[1]

Oreksinski receptor tip 1 (OX1R, OX₁, ili hipokretinski receptor tip 1), je protein koji je kod ljudi kodiran HCRTR1 genom.^[1]

Funkcija

OX₁ je G-protein spregnuti receptor koji je izražen u hipotalamusu i učestvuje u regulaciji ishrane. OX₁ selektivno vezuje neuropeptid oreksin-A. On je 64% identičan sa OX₂.^[1]

Ligandi

Agonisti

Oreksin-A

Antagonisti

Almoreksant - neselektivni OX_1/2 antagonist
SB-334,867 - selektivni OX₁ antagonist
SB-408,124 - selektivni OX₁ antagonist
SB-649,868 - neselektivni OX_1/2 antagonist

Vidi još

Oreksinski receptor

Literatura

^ ^а ^б „Entrez Gene: HCRTR1 hypocretin (orexin) receptor 1”.

Dodatna literatura

Flier JS, Maratos-Flier E (1998). „Obesity and the hypothalamus: novel peptides for new pathways.”. Cell. 92 (4): 437—40. PMID 9491885. doi:10.1016/S0092-8674(00)80937-X.
Willie JT, Chemelli RM, Sinton CM, Yanagisawa M (2001). „To eat or to sleep? Orexin in the regulation of feeding and wakefulness.”. Annu. Rev. Neurosci. 24: 429—58. PMID 11283317. doi:10.1146/annurev.neuro.24.1.429.
Hungs M, Mignot E (2001). „Hypocretin/orexin, sleep and narcolepsy.”. Bioessays. 23 (5): 397—408. PMID 11340621. doi:10.1002/bies.1058.
de Lecea L; Kilduff TS; Peyron C; et al. (1998). „The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.”. Proc. Natl. Acad. Sci. U.S.A. 95 (1): 322—7. PMC 18213 . PMID 9419374. doi:10.1073/pnas.95.1.322.
Sakurai T; Amemiya A; Ishii M; et al. (1998). „Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.” (PDF). Cell. 92 (4): 573—85. PMID 9491897. doi:10.1016/S0092-8674(00)80949-6. Архивирано из оригинала (PDF) 11. 07. 2011. г. Приступљено 22. 04. 2011.
Sakurai T; Amemiya A; Ishii M; et al. (1998). „Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.”. Cell. 92 (5): 697. PMID 9527442. doi:10.1016/S0092-8674(02)09256-5.
Peyron C; Faraco J; Rogers W; et al. (2000). „A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.”. Nat. Med. 6 (9): 991—7. PMID 10973318. doi:10.1038/79690.
Blanco M; López M; GarcIa-Caballero T; et al. (2001). „Cellular localization of orexin receptors in human pituitary.”. J. Clin. Endocrinol. Metab. 86 (7): 3444—7. PMID 11443222. doi:10.1210/jc.86.7.3444.
Olafsdóttir BR; Rye DB; Scammell TE; et al. (2002). „Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.”. Neurology. 57 (10): 1896—9. PMID 11723285.
Wieland HA; Söll RM; Doods HN; et al. (2002). „The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor.”. Eur. J. Biochem. 269 (4): 1128—35. PMID 11856342. doi:10.1046/j.0014-2956.2001.02739.x.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Hilairet S; Bouaboula M; Carrière D; et al. (2003). „Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716.”. J. Biol. Chem. 278 (26): 23731—7. PMID 12690115. doi:10.1074/jbc.M212369200.
Karteris E, Chen J, Randeva HS (2004). „Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system.”. J. Clin. Endocrinol. Metab. 89 (4): 1957—62. PMID 15070969. doi:10.1210/jc.2003-031778.
Holmqvist T; Johansson L; Ostman M; et al. (2005). „OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms.”. J. Biol. Chem. 280 (8): 6570—9. PMID 15611118. doi:10.1074/jbc.M407397200.
Spinazzi R; Rucinski M; Neri G; et al. (2005). „Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells.”. J. Clin. Endocrinol. Metab. 90 (6): 3544—9. PMID 15797953. doi:10.1210/jc.2004-2385.
Meerabux J; Iwayama Y; Sakurai T; et al. (2005). „Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects.”. Biol. Psychiatry. 58 (5): 401—7. PMID 15978554. doi:10.1016/j.biopsych.2005.04.015.
Ziolkowska A; Spinazzi R; Albertin G; et al. (2006). „Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 receptor.”. J. Steroid Biochem. Mol. Biol. 96 (5): 423—9. PMID 16157481. doi:10.1016/j.jsbmb.2005.05.003.

Spoljašnje veze

„Orexin Receptors: OX₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 06. 02. 2016. г.

[entrez-1] а ^б „Entrez Gene: HCRTR1 hypocretin (orexin) receptor 1”.

[1]