Moeksipril
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(IUPAC) ime
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(3S)-2-[(2S)-2- {[(2S)-1-etoksi-1-okso-4-fenilbutan-2-il]amino}propanoil]-6,7-dimetoksi-1,2,3,4-tetrahidroizohinolin-3-karboksilna kiselina
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Klinički podaci
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Robne marke
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Univasc
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AHFS/Drugs.com
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Monografija
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MedlinePlus
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a695018
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Identifikatori
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CAS broj
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103775-10-6
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ATC kod
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C09AA13
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PubChem[1][2]
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91270
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DrugBank
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DB00691
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ChemSpider[3]
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82418
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UNII
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WT87C52TJZ Y
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KEGG[4]
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D08225 Y
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ChEMBL[5]
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CHEMBL1165 Y
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Hemijski podaci
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Formula
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C27H34N2O7
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Mol. masa
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498,568 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C27H34N2O7/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32)/t17-,21-,22-/m0/s1 Key: UWWDHYUMIORJTA-HSQYWUDLSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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D(US)
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Pravni status
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POM (UK) ℞-only (SAD)
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Način primene
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Oralno
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Moeksipril hidrohlorid je potentan oralno aktivan nesulfhidrilni inhibitor angiotenzin konvertujućeg enzima (ACE),[6] koji se koristi za tretiranje hipertenzije i zatajenja srca. Moeksipril se može administrirati pojedinačno ili zajedno sa drugim antihipertenzivima ili diureticima.[7] On deluje putem inhibicije konverzije angiotenzina I u angiotenzin II.[8] Moeksipril je dostupan pod imenom Univasc.[8][9]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Hochadel, Maryanne, ur. (2006). The AARP Guide to Pills. Sterling Publishing Company. str. 640. ISBN 978-1-4027-1740-6. Pristupljeno 9. 10. 2009.
- ↑ Belal, F.F, K.M. Metwaly, and S.M. Amer. "Development of Membrane Electrodes for the Specific Determination of Moexipril Hydrochloride in Dosage Forms and Biological Fluids." Portugaliae Electrochimica Acta. 27.4 (2009): 463-475.
- ↑ 8,0 8,1 Rodgers, Katie, Michael C Vinson, and Marvin W Davis. "Breakthroughs: New drug approvals of 1995 -- part 1." Advanstar Communications, Inc. 140.3 (1996): 84.
- ↑ Dart, Richard C. (2004). Medical toxicology. Lippincott Williams & Wilkins. str. 647. ISBN 978-0-7817-2845-4. Pristupljeno 9. 10. 2009.