Fosaprepitant

Fosaprepitant

(IUPAC) ime
[3[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl] ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl5-oxo- 2H-1,2,4-triazol-1-yl]phosphonic acid
Klinički podaci
Identifikatori
CAS broj	172673-20-0 265121-04-8 (dimeglumin)
ATC kod	A04AD12
PubChem[1][2]	219090
Hemijski podaci
Formula	C23H22F7N4O6P
Mol. masa	614.406 g/mol
SMILES	eMolekuli & PubHem
InChI InChI=1S/C23H22F7N4O6P/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38)^Y Key: BARDROPHSZEBKC-UHFFFAOYSA-N^Y
Farmakokinetički podaci
Bioraspoloživost	n/a
Vezivanje za proteine plazme	>95% (aprepitant)
Metabolizam	u aprepitant
Poluvreme eliminacije	9 do 13 sati (aprepitant)
Farmakoinformacioni podaci
Licenca	EU EMEA:link, US FDA:link
Trudnoća	B(US)
Pravni status	℞-only (SAD)
Način primene	Intravenozno

Fosaprepitant (Emend injekcije (SAD), Ivemend (EU)) je antiemetički lek, koji se upotrebljava intravenozno. On je prolek aprepitanta.

Fosaprepitant je razvio Merk. On je odobren u SAD FDA 25. januara, 2008.^[3] i EMA 11. januara iste godine.^[4]

Povezano

• Aprepitant
• Kasopitant
• L-733,060
• Maropitant
• Vestipitant

Reference

1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
3. „Drugs.com, FDA Approves Emend (fosaprepitant dimeglumine) for Injection, Merck's New Intravenous Therapy, for Use in Combination with Other Antiemetics for Prevention of Nausea and Vomiting Caused by Chemotherapy”. Pristupljeno 15. 03. 2008. 
4. „European Public Assessment Report for Ivemend (from the EMEA website)”. Arhivirano iz originala na datum 2008-02-28. Pristupljeno 15. 03. 2008. 

Vanjske veze

	Portal Medicina
	Portal Hemija

Šablon:Neuropeptidni ligandi