CGS-12066A

CGS-12066A
IUPAC ime
	4-(4-metilpiperazin-1-il)-7-(trifluorometil)pirolo[1,2-a]hinoksalin
Identifikatori
CAS broj	109028-10-6
ATC kod	none
PubChem	CID 2689
IUPHAR/BPS	109
ChemSpider	2588
Hemijski podaci
Formula	C17H17F3N4
Molarna masa	334,338 g/mol
	SMILES C3CN(C)CCN3c2nc1cc(C(F)(F)F)ccc1n4cccc24; ;
	InChI InChI=1S/C17H17F3N4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16/h2-6,11H,7-10H2,1H3 ; Key:LXFHSCDLMBZYKY-UHFFFAOYSA-N ;

CGS-12066A je lek koji deluje kao potentan i selektivan agonist za 5-HT_1B receptora sa nižim afinitetom za tri 5-HT₂ receptorska tipa.^[1]^[2] On se koristi za istraživanje uloge 5-HT_1B receptora u različitim procesima uključujući percepciju bola, kao i cikluse spavanja i budnost.^[3]^[4]

Reference

^ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M. Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Archives of Pharmacology. 370 (2): 114—23. август 2004. PMID 15322733. doi:10.1007/s00210-004-0951-4. Недостаје или је празан параметар |title= (помоћ).
^ Jeong, H. S.; Jang, M. J.; Park, J. S. (15. 3. 2005). „Effects of CGS-12066A on medial vestibular nuclear neurons”. Brain Research. 1038 (1): 118—21. PMID 15748881.
^ Monti, J. M.; Jantos, H. (2008). „The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking”. Progress in Brain Research. 172: 625—46. PMID 18772053.
^ Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM. „The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats”. Neuroscience. 165 (2): 561—8. 20. 1. 2010. PMID 19837141.

Spoljašnje veze

[1] Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M. Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Archives of Pharmacology. 370 (2): 114—23. август 2004. PMID 15322733. doi:10.1007/s00210-004-0951-4. Недостаје или је празан параметар |title= (помоћ).

[2] Jeong, H. S.; Jang, M. J.; Park, J. S. (15. 3. 2005). „Effects of CGS-12066A on medial vestibular nuclear neurons”. Brain Research. 1038 (1): 118—21. PMID 15748881.

[3] Monti, J. M.; Jantos, H. (2008). „The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking”. Progress in Brain Research. 172: 625—46. PMID 18772053.

[4] Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM. „The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats”. Neuroscience. 165 (2): 561—8. 20. 1. 2010. PMID 19837141.

[1]

[2]

[3]

[4]