UH-301

UH-301

Clinical data
Other names	UH301; (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin; (S)-5-FHDPAT
Drug class	Serotonin 5-HT1A receptor antagonist
ATC code	None
Identifiers
IUPAC name (7S)-7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydronaphthalen-1-ol
CAS Number	127126-21-0^Y
PubChem CID	122187
IUPHAR/BPS	61
ChemSpider	108977^Y
UNII	1G916IMD7L
ChEMBL	ChEMBL22778
CompTox Dashboard (EPA)	DTXSID70155410
Chemical and physical data
Formula	C16H24FNO
Molar mass	265.372 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CCCN(CCC)[C@H]1CCC2=C(C=CC(=C2C1)O)F
InChI InChI=1S/C16H24FNO/c1-3-9-18(10-4-2)12-5-6-13-14(11-12)16(19)8-7-15(13)17/h7-8,12,19H,3-6,9-11H2,1-2H3/t12-/m0/s1 Key:FNKBVTBXFLSTPB-LBPRGKRZSA-N
(verify)

UH-301, also known as (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin ((S)-5-FHDPAT), is a drug and research chemical widely used in scientific studies. It acts as a selective serotonin 5-HT_1A receptor silent antagonist.^[1] It is structurally related to 8-OH-DPAT.^[1] UH-301 was found to produce a head-twitch response in mice which is usually typical of 5-HT_2A agonist drugs, and has subsequently been used to investigate how 5-HT_1A receptor activity modulates 5-HT_2A receptors downstream.^[2]

See also

• Substituted 2-aminotetralin
• 4-HO-DPT
• Robalzotan
• UH-232

References

1. Björk L, Cornfield LJ, Nelson DL, Hillver SE, Andén NE, Lewander T, Hacksell U (July 1991). "Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects". The Journal of Pharmacology and Experimental Therapeutics. 258 (1): 58–65. PMID 1830099.
2. Darmani NA, Reeves SL (September 1996). "The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice". Pharmacology, Biochemistry, and Behavior. 55 (1): 1–10. doi:10.1016/0091-3057(96)00072-X. PMID 8870031. S2CID 25607128.