E-6801

E-6801
	(6-hloro-N-(3-(2-(dimetilamino)etil)-1H-indol-5-il)imidazo[2,1-b]tiazol-5-sulfonamid)
Identifikacija
PubChem	10202564
ChemSpider	8378062
ChEMBL	CHEMBL362628
Jmol-3D slike	Slika 1
SMILES
	CN(C)CCC1=CNC2=C1C=C(C=C2)NS(=O)(=O)C3=C(N=C4N3C=CS4)Cl
InChI
	InChI=InChI=1S/C17H18ClN5O2S2/c1-22(2)6-5-11-10-19-14-4-3-12(9-13(11)14)21-27(24,25)16-15(18)20-17-23(16)7-8-26-17/h3-4,7-10,19,21H,5-6H2,1-2H3 ; Kod: RZAXUKVIIWUIOM-UHFFFAOYSA-N
Svojstva
Molekulska formula	C17H18ClN5O2S2
Molarna masa	423,94 g mol-1
	; ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

E-6801 je parcijalni agonist 5-HT₆ receptora.^[5] On poboljšava memoriju prepoznavanja i poništava memorijski deficit uzrokovan skopolaminom kod pacova u modelima prepoznavanja objekata.^[6] Mehanizam memorijskog poboljšanja je baziran na kombinovanoj modulaciji holinergičke i glutamatergičkie neurotransmisije.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Romero, G. (August 2006). „Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways”. British Journal of Pharmacology 148 (8): 1133–43. DOI:10.1038/sj.bjp.0706827. PMC 1752021. PMID 16865095. Pristupljeno 2011-12-24.
↑ Kendall, I. (February 2011). „E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat.”. Psychopharmacology 213 (2-3): 413–30. PMID 20405281.

Povezano

E-6837

Spoljašnje veze

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[Romero-5] Romero, G. (August 2006). „Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways”. British Journal of Pharmacology 148 (8): 1133–43. DOI:10.1038/sj.bjp.0706827. PMC 1752021. PMID 16865095. Pristupljeno 2011-12-24.

[Kendall-6] Kendall, I. (February 2011). „E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat.”. Psychopharmacology 213 (2-3): 413–30. PMID 20405281.

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