Oksaflozan

Oksaflozan
IUPAC ime
4-propan-2-il-2-[3-(trifluorometil)fenil]morfolin
Klinički podaci
Način primeneOralno
Pravni status
Pravni status
  • ℞ (Prescription only)
Identifikatori
CAS broj26629-86-7 ДаY
ATC kodN06AX10 (WHO)
PubChemCID 432824
ChemSpider382782
UNIIV4WLW77V5Q ДаY
KEGGD07340
Hemijski podaci
FormulaC14H18F3NO
Molarna masa273,29 g/mol
  • O1CCN(C(C)C)CC1c2cc(C(F)(F)F)ccc2

Oksaflozan (Confliktan) je antidepresiv i anksiolitik koji je uveden u prodaju 1982. za tretmant depresije, ali je u međuvremenu izašao iz upotrebe.[1][2] On je prolek za N-dealkiloksaflozan, koji deluje kao neselektivni agonist serotoninskih receptora: 5-HT1A (pKi = 7,1), 5-HT2A (pKi = 6,0), i 5-HT2C (pKi = 7,5).[3] Oksaflozan potencijalno ima i antiholinergičko dejstvo pri visokim dozama.[4]

Reference

[уреди | уреди извор]
  1. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. стр. 766. ISBN 978-3-88763-075-1. 
  2. ^ Sittig 1988, стр. 1122.
  3. ^ Leysen DC (1999). „Selective 5-HT2C agonists as potential antidepressants”. IDrugs : the Investigational Drugs Journal. 2 (2): 109—20. PMID 16160946. 
  4. ^ Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E (1992). „Oxaflozane overdose in a child”. Journal of Toxicology. Clinical Toxicology. 30 (1): 123—6. PMID 1542141. 

Literatura

[уреди | уреди извор]
  • Sittig, Marshall (1988). Pharmaceutical manufacturing encyclopedia. Park Ridge, N.J., U.S.A: Noyes Publications. стр. 1756. ISBN 978-0-8155-1144-1. 
  • Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. стр. 1932. ISBN 978-3-88763-075-1. 
  • Rascol A, Maurel H, David J, Layani M (1974). „[Preliminary clinical results of a new non tricyclic antidepressive drug: oxaflozane]”. Thérapie (на језику: French). 29 (1): 95—9. PMID 4603757. 
  • Hache J, Duchene-Marullaz P, Streichenberger G (1974). „[Pharmacological profile of a new non tricyclic antidepressant: oxaflozane (1,766 Cerm)]”. Thérapie (на језику: French). 29 (1): 81—93. PMID 4849381. 
  • Constantin M, Pognat JF (1979). „Comparative study of oxaflozane urinary metabolism in man, the dog and the rat. Identification of the principal metabolites”. Arzneimittel-Forschung. 29 (1): 109—14. PMID 582104. 
  • Bertolino A, palermo M, Porro V (1985). „Oxaflozane, a new nontricyclic antidepressant in the treatment of anxiety-depressions syndromes.”. Acta Ther (11): 209—218. 
  • Aguglia E (1986). „On the therapetic value of axaflozane: Its application in the treatment of emotional disturbances of the anxious-depressive type accompanied by somatic manifestations.”. Acta Ther (12): 259—267. 

Spoljašnje veze

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