CP-809,101

CP-809,101
(IUPAC) ime
	2-[(3-Hlorofenil)metoksi]-6-(1-piperazinil)pirazin
Klinički podaci
Identifikatori
CAS broj	479683-64-2
ATC kod	nije dodeljen
Hemijski podaci
Formula	C15H17ClN4O
Mol. masa	304,774 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C15H17ClN4O/c16-13-3-1-2-12(8-13)11-21-15-10-18-9-14(19-15)20-6-4-17-5-7-20/h1-3,8-10,17H,4-7,11H2 ; Key: PCWGGOVOEWHPMG-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

CP-809,101 je lek koji deluje kao potentan i selektivan agonist 5-HT_2C receptora.^[1] On je proizveo obećavajuće rezultate u životinjskim modelima gojaznosti i psihoze, ali isto tako uzrokuje genotoksičnost, te je njegova upotreba ograničena na naučna istraživanja.^[2]^[3]

Reference

↑ Strong PV, Greenwood BN, Fleshner M (May 2009). „The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats”. Psychopharmacology 203 (4): 665–75. DOI:10.1007/s00213-008-1413-3. PMID 19037632.
↑ Siuciak JA, Chapin DS, McCarthy SA, Guanowsky V, Brown J, Chiang P, Marala R, Patterson T, Seymour PA, Swick A, Iredale PA (February 2007). „CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity”. Neuropharmacology 52 (2): 279–90. DOI:10.1016/j.neuropharm.2006.07.024. PMID 16949622.
↑ Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV, Soliman VF, Schildknegt K (June 2007). „Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation”. Drug Metabolism and Disposition: the Biological Fate of Chemicals 35 (6): 848–58. DOI:10.1124/dmd.106.013649. PMID 17344339.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[pmid19037632-1] Strong PV, Greenwood BN, Fleshner M (May 2009). „The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats”. Psychopharmacology 203 (4): 665–75. DOI:10.1007/s00213-008-1413-3. PMID 19037632.

[pmid16949622-2] Siuciak JA, Chapin DS, McCarthy SA, Guanowsky V, Brown J, Chiang P, Marala R, Patterson T, Seymour PA, Swick A, Iredale PA (February 2007). „CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity”. Neuropharmacology 52 (2): 279–90. DOI:10.1016/j.neuropharm.2006.07.024. PMID 16949622.

[pmid17344339-3] Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV, Soliman VF, Schildknegt K (June 2007). „Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation”. Drug Metabolism and Disposition: the Biological Fate of Chemicals 35 (6): 848–58. DOI:10.1124/dmd.106.013649. PMID 17344339.

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